The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Ultra-responsive soft matter from strain-stiffening hydrogels
Open accessAbstract
The stiffness of hydrogels is crucial for their application. Nature’s hydrogels become stiffer as they are strained. This stiffness is not constant but increases when the gel is strained. This stiffening is used, for instance, by cells that actively strain their environment to modulate their function. When optimized, such strain-stiffening materials become extremely sensitive and very responsive to stress. Strain stiffening, however, is unexplored in synthetic gels since the structural design parameters are unknown. Here we uncover how readily tuneable parameters such as concentration, temperature and polymer length impact the stiffening behaviour. Our work also reveals the marginal point, a well-described but never observed, critical point in the gelation process. Around this point, we observe a transition from a low-viscous liquid to an elastic gel upon applying minute stresses. Our experimental work in combination with network theory yields universal design principles for future strain-stiffening materials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Complexity in biomaterials for tissue engineering
Place, E. S., Evans, N. D., & Stevens, M. M. (2009) · Nature Materials · doi:10.1038/nmat2441 · Cited by 1,728
Nonlinear elasticity in biological gels
Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,703
Self-citationElastic Behavior of Cross-Linked and Bundled Actin Networks
Gardel, M. L., Shin, J. H., MacKintosh, F. C., Mahadevan, L., Matsudaira, P., & Weitz, D. A. (2004) · Science · doi:10.1126/science.1095087 · Cited by 1,256
Self-citationElasticity of Semiflexible Biopolymer Networks
MacKintosh, F. C., Käs, J., & Janmey, P. A. (1995) · Physical Review Letters · doi:10.1103/physrevlett.75.4425 · Cited by 1,068
Self-citationInterplay of matrix stiffness and protein tethering in stem cell differentiation
Wen, J. H., Vincent, L. G., Fuhrmann, A., Choi, Y. S., Hribar, K. C., Taylor-Weiner, H., Chen, S., & Engler, A. J. (2014) · Nature Materials · doi:10.1038/nmat4051 · Cited by 937
Chaudhuri, O., Koshy, S. T., Branco da Cunha, C., Shin, J.-W., Verbeke, C. S., Allison, K. H., & Mooney, D. J. (2014) · Nature Materials · doi:10.1038/nmat4009 · Cited by 820
Modeling semiflexible polymer networks
Broedersz, C. P., & MacKintosh, F. C. (2014) · Reviews of Modern Physics · doi:10.1103/revmodphys.86.995 · Cited by 733
Self-citationStiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics
Guvendiren, M., & Burdick, J. A. (2012) · Nature Communications · doi:10.1038/ncomms1792 · Cited by 707
Cited by
Yashima, E., Ousaka, N., Taura, D., Shimomura, K., Ikai, T., & Maeda, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00354 · Cited by 2,004
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Gels with sense: supramolecular materials that respond to heat, light and sound
Jones, C. D., & Steed, J. W. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00435k · Cited by 487
Hydrogels for Liver Tissue Engineering
Ye, S., Boeter, J. W. B., Penning, L. C., Spee, B., & Schneeberger, K. (2019) · Bioengineering · doi:10.3390/bioengineering6030059 · Cited by 112
Metadata
- Authors
- Jaspers, M., Dennison, M., Mabesoone, M. F. J., MacKintosh, F. C., Rowan, A. E., & Kouwer, P. H. J.
- Venue
- Nature Communications
- Published
- 2014-12-16
- Volume
- 5
- Issue
- 1
- Pages
- 5808-5808
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2042833543
- Cited by
- 255
- References
- 21
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ultra-responsive soft matter from strain-stiffening hydrogels. https://app.cochat.ai/papers/10.1038/ncomms6808
- The paper
- Jaspers, M., Dennison, M., Mabesoone, M. F. J., MacKintosh, F. C., Rowan, A. E., & Kouwer, P. H. J. (2014). Ultra-responsive soft matter from strain-stiffening hydrogels. Nature Communications. https://doi.org/10.1038/ncomms6808
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.