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Cited by 553

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Dynamic modeling of the central carbon metabolism of Escherichia coli

Chassagnole, Christophe, Noisommit‐Rizzi, Naruemol, Schmid, Joachim W., Mauch, Klaus, Reuss, Matthias·2002·Biotechnology and Bioengineering
DOI 10.1002/bit.10288
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Abstract

Application of metabolic engineering principles to the rational design of microbial production processes crucially depends on the ability to describe quantitatively the systemic behavior of the central carbon metabolism to redirect carbon fluxes to the product‐forming pathways. Despite the importance for several production processes, development of an essential dynamic model for central carbon metabolism of Escherichia coli has been severely hampered by the current lack of kinetic information on the dynamics of the metabolic reactions. Here we present the design and experimental validation of such a dynamic model, which, for the first time, links the sugar transport system (i.e., phosphotransferase system [PTS]) with the reactions of glycolysis and the pentose‐phosphate pathway. Experimental observations of intracellular concentrations of metabolites and cometabolites at transient conditions are used to validate the structure of the model and to estimate the kinetic parameters. Further analysis of the detailed characteristics of the system offers the possibility of studying important questions regarding the stability and control of metabolic fluxes. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 79: 53–73; 2002.

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Research works printed but not linked: 30

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Metadata

Authors
Chassagnole, C., Noisommit‐Rizzi, N., Schmid, J. W., Mauch, K., & Reuss, M.
Venue
Biotechnology and Bioengineering
Publisher
Wiley
Published
2002-05-09
Volume
79
Issue
1
Pages
53-73
ISSN
  • 0006-3592 (ISSN-L)
  • 1097-0290
DOI
10.1002/bit.10288
OpenAlex
W2053339983
Cited by
553
References
49
FWCI
4.00
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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