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Prediction of diffusion coefficients of proteins
Abstract
A correlation for predicting the diffusion coefficients of proteins at standard conditions is proposed by adapting the Stokes‐Einstein equation to a model for the equivalent hydrodynamic sphere. The radius of gyration, which accounts for the size and shape of protein molecules in solution, was used in deriving the new correlation. The correlation successfully predicted the diffusion coefficients of proteins, for which experimental data were available, with a higher degree of accuracy than achieved by previous correlation methods.
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Cited by
McAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859
Immobilized enzymes: crystals or carriers?
Tischer, W. (1999) · Trends in Biotechnology · doi:10.1016/s0167-7799(99)01322-0 · Cited by 406
Physical limits of cells and proteomes
Dill, K. A., Ghosh, K., & Schmit, J. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114477108 · Cited by 298
Thorne, R. G., Hrabětová, S., & Nicholson, C. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00352.2004 · Cited by 168
Pepsin diffusivity in whey protein gels and its effect on gastric digestion
Luo, Q., Borst, J. W., Westphal, A. H., Boom, R. M., & Janssen, A. E. M. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.11.046 · Cited by 123
Metadata
- Authors
- Tyn, M. T., & Gusek, T. W.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 1990-02-20
- Volume
- 35
- Issue
- 4
- Pages
- 327-338
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W1990245659
- Cited by
- 421
- References
- 0
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tyn, M. T., & Gusek, T. W. (1990). Prediction of diffusion coefficients of proteins. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.260350402
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