The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Formation of microparticulate protein powder using a supercritical fluid antisolvent
Abstract
Gas antisolvent (GAS) expansion of dimethylsulfoxide (DMSO) and N,N‐dimethylformamide (DMFA) solutions with supercritical carbon dioxide was used to produce biologically active powders of insulin. Powders with 90% of the particles smaller than 4 μm and 10% smaller than 1 μm were obtained under all conditions tested when the process was operated continuously, with small liquid droplets sprayed into a flowing supercritical continuum. Slow pressurization of the stagnant protein solution resulted in larger particles. In vivo tests on rats revealed no differences between the biological activity of processed and unprocessed insulin, GAS processing of organic solution appears to be a reliable and effective method for the production of dry, biologically active microparticulate powders of peptides and proteins. © 1993 John Wiley & Sons, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Langer, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
Cited by
Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering
Annabi, N., Nichol, J. W., Zhong, X., Ji, C., Koshy, S., Khademhosseini, A., & Dehghani, F. (2010) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2009.0639 · Cited by 1,308
Pharmaceutical Processing with Supercritical Carbon Dioxide
Subramaniam, B., Rajewski, R. A., & Snavely, K. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9700661 · Cited by 444
Hile, D. D., Amirpour, M. L., Akgerman, A., & Pishko, M. V. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00268-0 · Cited by 210
Stabilization of proteins in dry powder formulations using supercritical fluid technology
Jovanović, N., Bouchard, A., Hofland, G. W., Witkamp, G.-J., Crommelin, D. J. A., & Jiskoot, W. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000048185.09483.e7 · Cited by 111
Metadata
- Authors
- Yeo, S., Lim, G., Debendetti, P. G., & Bernstein, H.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 1993-02-05
- Volume
- 41
- Issue
- 3
- Pages
- 341-346
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W1982303551
- Cited by
- 305
- References
- 1
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Formation of microparticulate protein powder using a supercritical fluid antisolvent. https://app.cochat.ai/papers/10.1002/bit.260410308
- The paper
- Yeo, S., Lim, G., Debendetti, P. G., & Bernstein, H. (1993). Formation of microparticulate protein powder using a supercritical fluid antisolvent. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.260410308
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
