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The application of electrosprayed minocycline‐loaded PLGA microparticles for the treatment of glioblastoma

Arriaga, Marco A., Amieva, Juan A., Quintanilla, Jaqueline, Jimenez, Angela, Ledezma, Julio, Lopez, Silverio, Martirosyan, Karen S., Chew, Sue Anne·2023·Biotechnology and Bioengineering
DOI 10.1002/bit.28527
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Abstract

The survival of patients with glioblastoma multiforme (GBM), the most common and invasive form of malignant brain tumors, remains poor despite advances in current treatment methods including surgery, radiotherapy, and chemotherapy. Minocycline is a semi‐synthetic tetracycline derivative that has been widely used as an antibiotic and more recently, it has been utilized as an antiangiogenic factor to inhibit tumorigenesis. The objective of this study was to investigate the utilization of electrospraying process to fabricate minocycline‐loaded poly(lactic‐co‐glycolic acid) (PLGA) microparticles with high drug loading and loading efficiency and to evaluate their ability to induce cell toxicity in human glioblastoma (i.e., U87‐MG) cells. The results from this study demonstrated that solvent mixture of dicholoromethane (DCM) and methanol is the optimal solvent combination for minocycline and larger amount of methanol (i.e., 70:30) resulted in a higher drug loading. All three solvent ratios of DCM:methanol tested produced microparticles that were both spherical and smooth, all in the micron size range. The electrosprayed microparticles were able to elicit a cytotoxic response in U87‐MG glioblastoma cells at a lower concentration of drug compared to the free drug. This work provides proof of concept to the hypothesis that electrosprayed minocycline‐loaded PLGA microparticles can be a promising agent for the treatment of GBM and could have potential application for cancer therapies.

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Metadata

Authors
Arriaga, M. A., Amieva, J. A., Quintanilla, J., Jimenez, A., Ledezma, J., Lopez, S., Martirosyan, K. S., & Chew, S. A.
Venue
Biotechnology and Bioengineering
Publisher
Wiley
Published
2023-08-22
Volume
120
Issue
11
Pages
3409-3422
ISSN
  • 0006-3592
  • 1097-0290
DOI
10.1002/bit.28527
Cited by
2
References
5
Language
en
Licence
Funders
  • National Institute of General Medical Sciences
  • National Science Foundation

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CoChat. (2026). Citation check: The application of electrosprayed minocycline‐loaded PLGA microparticles for the treatment of glioblastoma. https://app.cochat.ai/papers/10.1002/bit.28527
The paper
Arriaga, M. A., Amieva, J. A., Quintanilla, J., Jimenez, A., Ledezma, J., Lopez, S., Martirosyan, K. S., & Chew, S. A. (2023). The application of electrosprayed minocycline‐loaded PLGA microparticles for the treatment of glioblastoma. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.28527

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.