The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Influence of body composition profile on outcomes following colorectal cancer surgery
Abstract
Background: Muscle depletion is characterized by reduced muscle mass (myopenia), and increased infiltration by intermuscular and intramuscular fat (myosteatosis). This study examined the role of particular body composition profiles as prognostic markers for patients with colorectal cancer undergoing curative resection. Methods: Patients with colorectal cancer undergoing elective surgical resection between 2006 and 2011 were included. Lumbar skeletal muscle index (LSMI), visceral adipose tissue (VAT) surface area and mean muscle attenuation (MA) were calculated by analysis of CT images. Reduced LSMI (myopenia), increased VAT (visceral obesity) and low MA (myosteatosis) were identified using predefined sex-specific skeletal muscle index values. Univariable and multivariable Cox regression models were used to determine the role of different body composition profiles on outcomes. Results: Some 805 patients were identified, with a median follow-up of 47 (i.q.r. 24·9–65·6) months. Multivariable analysis identified myopenia as an independent prognostic factor for disease-free survival (hazard ratio (HR) 1·53, 95 per cent c.i. 1·06 to 2·39; P = 0·041) and overall survival (HR 1·70, 1·25 to 2·31; P < 0·001). The presence of myosteatosis was associated with prolonged primary hospital stay (P = 0·034), and myopenic obesity was related to higher 30-day morbidity (P = 0·019) and mortality (P < 0·001) rates. Conclusion: Myopenia may have an independent prognostic effect on cancer survival for patients with colorectal cancer. Muscle depletion may represent a modifiable risk factor in patients with colorectal cancer and needs to be targeted as a relevant endpoint of health recommendations.
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Cites
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Colorectal cancer statistics, 2014
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Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss
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Self-citationBody Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Mourtzakis, M., Mulder, K. E., Reiman, T., Butts, C. A., Scarfe, A. G., & Sawyer, M. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3067 · Cited by 619
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Human dendritic cells. Enrichment and characterization from peripheral blood
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Cited by
Wischmeyer, P. E., Carli, F., Evans, D. C., Guilbert, S., Kozar, R., Pryor, A., Thiele, R. H., Everett, S., Grocott, M., Gan, T. J., et al. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002743 · Cited by 485
Simonsen, C., de Heer, P., Bjerre, E. D., Suetta, C., Hojman, P., Pedersen, B. K., Svendsen, L. B., & Christensen, J. F. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002679 · Cited by 375
Baracos, V. E., & Arribas, L. (2018) · Annals of Oncology · doi:10.1093/annonc/mdx810 · Cited by 362
Automated Abdominal Segmentation of CT Scans for Body Composition Analysis Using Deep Learning
Weston, A. D., Korfiatis, P., Kline, T. L., Philbrick, K. A., Kostandy, P., Sakinis, T., Sugimoto, M., Takahashi, N., & Erickson, B. J. (2019) · Radiology · doi:10.1148/radiol.2018181432 · Cited by 358
Prehabilitation, enhanced recovery after surgery, or both? A narrative review
Gillis, C., Ljungqvist, O., & Carli, F. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.12.007 · Cited by 308
Metadata
- Authors
- Malietzis, G., Currie, A. C., Athanasiou, T., Johns, N., Anyamene, N., Glynne-Jones, R., Kennedy, R. H., Fearon, K. C. H., & Jenkins, J. T.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-16
- Volume
- 103
- Issue
- 5
- Pages
- 572-580
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2301680230
- Cited by
- 299
- References
- 28
- FWCI
- 16.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Malietzis, G., Currie, A. C., Athanasiou, T., Johns, N., Anyamene, N., Glynne-Jones, R., Kennedy, R. H., Fearon, K. C. H., & Jenkins, J. T. (2016). Influence of body composition profile on outcomes following colorectal cancer surgery. British Journal of Surgery. https://doi.org/10.1002/bjs.10075
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