The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Influence of body composition profile on outcomes following colorectal cancer surgery
Abstract
Background: Muscle depletion is characterized by reduced muscle mass (myopenia), and increased infiltration by intermuscular and intramuscular fat (myosteatosis). This study examined the role of particular body composition profiles as prognostic markers for patients with colorectal cancer undergoing curative resection. Methods: Patients with colorectal cancer undergoing elective surgical resection between 2006 and 2011 were included. Lumbar skeletal muscle index (LSMI), visceral adipose tissue (VAT) surface area and mean muscle attenuation (MA) were calculated by analysis of CT images. Reduced LSMI (myopenia), increased VAT (visceral obesity) and low MA (myosteatosis) were identified using predefined sex-specific skeletal muscle index values. Univariable and multivariable Cox regression models were used to determine the role of different body composition profiles on outcomes. Results: Some 805 patients were identified, with a median follow-up of 47 (i.q.r. 24·9–65·6) months. Multivariable analysis identified myopenia as an independent prognostic factor for disease-free survival (hazard ratio (HR) 1·53, 95 per cent c.i. 1·06 to 2·39; P = 0·041) and overall survival (HR 1·70, 1·25 to 2·31; P < 0·001). The presence of myosteatosis was associated with prolonged primary hospital stay (P = 0·034), and myopenic obesity was related to higher 30-day morbidity (P = 0·019) and mortality (P < 0·001) rates. Conclusion: Myopenia may have an independent prognostic effect on cancer survival for patients with colorectal cancer. Muscle depletion may represent a modifiable risk factor in patients with colorectal cancer and needs to be targeted as a relevant endpoint of health recommendations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dindo, D., Demartines, N., & Clavien, P.-A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133083.54934.ae · Cited by 31,378
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Colorectal cancer statistics, 2014
Siegel, R., DeSantis, C., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21220 · Cited by 2,562
Mourtzakis, M., Prado, C. M. M., Lieffers, J. R., Reiman, T., McCargar, L. J., & Baracos, V. E. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-075 · Cited by 2,224
Rahbari, N. N., Weitz, J., Hohenberger, W., Heald, R. J., Moran, B., Ulrich, A., Holm, T., Wong, W. D., Tiret, E., Moriya, Y., et al. (2010) · Surgery · doi:10.1016/j.surg.2009.10.012 · Cited by 1,559
Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss
Martin, L., Senesse, P., Gioulbasanis, I., Antoun, S., Bozzetti, F., Deans, C., Strasser, F., Thoresen, L., Jagoe, R. T., Chasen, M., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.1894 · Cited by 798
Self-citationBody Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Mourtzakis, M., Mulder, K. E., Reiman, T., Butts, C. A., Scarfe, A. G., & Sawyer, M. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3067 · Cited by 619
Li, C., Carli, F., Lee, L., Charlebois, P., Stein, B., Liberman, A. S., Kaneva, P., Augustin, B., Wongyingsinn, M., Gamsa, A., et al. (2013) · Surgical Endoscopy · doi:10.1007/s00464-012-2560-5 · Cited by 588
Biolo, G., Cederholm, T., & Muscaritoli, M. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.03.007 · Cited by 407
Human dendritic cells. Enrichment and characterization from peripheral blood
Van Voorhis, W., Hair, L., Steinman, R., & Kaplan, G. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.155.4.1172 · Cited by 388
Cancer and systemic inflammation: treat the tumour and treat the host
Roxburgh, C. S. D., & McMillan, D. C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.90 · Cited by 368
Honda, H., Qureshi, A. R., Axelsson, J., Heimburger, O., Suliman, M. E., Barany, P., Stenvinkel, P., & Lindholm, B. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.633 · Cited by 282
Adjuvant Therapy for completely resected Stage II Colon Cancer
Figueredo, A., Coombes, M. E., & Mukherjee, S. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005390.pub2 · Cited by 266
Psychological Prehabilitation Before Cancer Surgery: A Systematic Review
Tsimopoulou, I., Pasquali, S., Howard, R., Desai, A., Gourevitch, D., Tolosa, I., & Vohra, R. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4550-z · Cited by 264
Sarcopenia is predictive of nosocomial infection in care of the elderly
Cosquéric, G., Sebag, A., Ducolombier, C., Thomas, C., Piette, F., & Weill-Engerer, S. (2006) · British Journal of Nutrition · doi:10.1017/bjn20061943 · Cited by 242
Miljkovic, I., & Zmuda, J. M. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328337d826 · Cited by 234
The evaluation of body composition: A useful tool for clinical practice
Thibault, R., & Pichard, C. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000334879 · Cited by 193
Doyle, S. L., Bennett, A. M., Donohoe, C. L., Mongan, A. M., Howard, J. M., Lithander, F. E., Pidgeon, G. P., Reynolds, J. V., & Lysaght, J. (2013) · Nutrition Research · doi:10.1016/j.nutres.2012.12.007 · Cited by 185
Amundson, D. E., Djurkovic, S., & Matwiyoff, G. N. (2010) · Critical Care Clinics · doi:10.1016/j.ccc.2010.06.004 · Cited by 182
Myopenia—a new universal term for muscle wasting
Fearon, K., Evans, W. J., & Anker, S. D. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0025-7 · Cited by 173
Self-citationMalietzis, G., Aziz, O., Bagnall, N. M., Johns, N., Fearon, K. C., & Jenkins, J. T. (2015) · European Journal of Surgical Oncology (EJSO) · doi:10.1016/j.ejso.2014.10.056 · Cited by 173
Self-citationNIH ImageJ and Slice‐O‐Matic Computed Tomography Imaging Software to Quantify Soft Tissue
Irving, B. A., Weltman, J. Y., Brock, D. W., Davis, C. K., Gaesser, G. A., & WELTMAN, A. L. (2007) · Obesity · doi:10.1038/oby.2007.573 · Cited by 164
Richards, C. H., Roxburgh, C. S. D., MacMillan, M. T., Isswiasi, S., Robertson, E. G., Guthrie, G. K., Horgan, P. G., & McMillan, D. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041883 · Cited by 161
The views and practice of oncologists towards nutritional support in patients receiving chemotherapy
Spiro, A., Baldwin, C., Patterson, A., Thomas, J. E., & Andreyev, J. N. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603280 · Cited by 152
Cost of Major Surgery in the Sarcopenic Patient
Sheetz, K. H., Waits, S. A., Terjimanian, M. N., Sullivan, J. A., Campbell, D. A., Wang, S. C., & Englesbe, M. J. (2013) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2013.04.042 · Cited by 104
Patient optimization for gastrointestinal cancer surgery
Fearon, K. C. H., Jenkins, J. T., Carli, F., & Lassen, K. (2012) · British journal of surgery · doi:10.1002/bjs.8988 · Cited by 101
Self-citationCruz, R. J., Dew, M. A., Myaskovsky, L., Goodpaster, B., Fox, K. R., Fontes, P., & DiMartini, A. F. (2013) · Transplantation · doi:10.1097/tp.0b013e31827a0f27 · Cited by 99
Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review
Tan, B. H. L., Ross, J. A., Kaasa, S., Skorpen, F., & Fearon, K. C. H. (2011) · Journal of Genetics · doi:10.1007/s12041-011-0027-4 · Cited by 58
Self-citation
Cited by
Wischmeyer, P. E., Carli, F., Evans, D. C., Guilbert, S., Kozar, R., Pryor, A., Thiele, R. H., Everett, S., Grocott, M., Gan, T. J., et al. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002743 · Cited by 485
Simonsen, C., de Heer, P., Bjerre, E. D., Suetta, C., Hojman, P., Pedersen, B. K., Svendsen, L. B., & Christensen, J. F. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002679 · Cited by 375
Baracos, V. E., & Arribas, L. (2018) · Annals of Oncology · doi:10.1093/annonc/mdx810 · Cited by 362
Automated Abdominal Segmentation of CT Scans for Body Composition Analysis Using Deep Learning
Weston, A. D., Korfiatis, P., Kline, T. L., Philbrick, K. A., Kostandy, P., Sakinis, T., Sugimoto, M., Takahashi, N., & Erickson, B. J. (2019) · Radiology · doi:10.1148/radiol.2018181432 · Cited by 358
Prehabilitation, enhanced recovery after surgery, or both? A narrative review
Gillis, C., Ljungqvist, O., & Carli, F. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.12.007 · Cited by 308
Metadata
- Authors
- Malietzis, G., Currie, A. C., Athanasiou, T., Johns, N., Anyamene, N., Glynne-Jones, R., Kennedy, R. H., Fearon, K. C. H., & Jenkins, J. T.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-16
- Volume
- 103
- Issue
- 5
- Pages
- 572-580
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2301680230
- Cited by
- 299
- References
- 28
- FWCI
- 16.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
