The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Total parenteral nutrition as the sole therapy in Crohn's disease—a prospective study
Abstract
The effect of total parenteral nutrition (TPN) as sole therapy was studied in 30 consecutive cases of complicated Crohn's disease. After insertion of a Broviac-type central venous catheter patients were nourished parenterally for 3 weeks in the hospital and then for an additional 9 weeks at home. During this time no medication or oral intake was allowed. Surgery was avoided in 25 patients by TPN. These patients returned to work, ate normal meals and needed no medical support. In 5 cases it was not possible to control the acute disease and the patients were treated by resection. During TPN, catheter-related sepsis occurred in 3 patients (0.9 cases/1000 days TPN) and catheter embolism in 2. Four other patients developed intrahepatic cholestasis. A relapse of Crohn's disease was observed in 17 cases 3-48 months after the course of TPN. The cumulative recurrence rate is 60 per cent after 2 years and 85 per cent after 4 years. Compared with the results of resection, obtained from a 10-year period before TPN was instituted at our hospital, the cumulative recurrence rate after TPN is four times higher. It is concluded that TPN is not an alternative to resection in the treatment of Crohn's disease and should be reserved for patients with multifocal lesions, when surgery is not advisable because of the risk of a short bowel syndrome.
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“In a prospective study of 30 patients with CD treated with bowel rest and TPN, 25 (83%) achieved initial remission, but relapse was common73.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [73]
Citations
Cites
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
A silicone rubber atrial catheter for prolonged parenteral alimentation.
Broviac, J. W., Cole, J. J., & Scribner, B. H. (1973) · PubMed · Cited by 550
PREOPERATIVE PARENTERAL FEEDING IN PATIENTS WITH GASTROINTESTINAL CARCINOMA
Müller, J. M., DIENST, C., Brenner, U., & Pichlmaier, H. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90212-4 · Cited by 487
Dudrick, S. J., MacFadyen, B. V., Buren, C. T. V., RUBERG, R. L., & MAYNARD, A. T. (1972) · Annals of Surgery · doi:10.1097/00000658-197209000-00001 · Cited by 229
Prognosis after resection of chronic regional ileitis.
Lennard-Jones, J. E., & Stalder, G. (1967) · Gut · doi:10.1136/gut.8.4.332 · Cited by 170
Hyperammonemia accompanying parenteral nutrition in newborn infants
Johnson, J. D., Albritton, W. L., & Sunshine, P. (1972) · The Journal of Pediatrics · doi:10.1016/s0022-3476(72)80395-0 · Cited by 160
Total Parenteral Nutrition in Inflammatory Bowel Disease
Driscoll, R. H., & Rosenberg, I. H. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31831-4 · Cited by 158
The effects of protein calorie malnutrition on immune competence of the surgical patient.
Law, D. K., Dudrick, S. J., & Abdou, N. I. (1974) · PubMed · Cited by 131
An evaluation of total parenteral nutrition in the management of inflammatory bowel disease
Elson, C. O., Layden, T. J., Nemchausky, B. A., Rosenberg, J. L., & Rosenberg, I. H. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01312731 · Cited by 111
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Research works printed but not linked: 4
- Steiger, 1969, Total intravenous nutrition in the management of inflammatory disease of the intestinal tract, Fed. Proc., 28, 808
- Zeitler, 1972, Morbus Crohn
- Greenberg, 1976, Total parenteral nutrition and bowel rest in the management of Crohn's disease, Gut, 17, 828
- Oberhelman, 1971, Skandia Symposium on Regional Enteritis
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Items 101–101 of 101
Nutrition in inflammatory bowel disease: new trends
Kuk, N., Yao, C. K., Srinivasan, A. R., & Vasudevan, A. (2025) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001140
Metadata
- Authors
- Müller, J. M., Keller, H. W., Erasmi, H., & Pichlmaier, H.
- Affiliations
- University of Cologne (DE)
- ORCID
- Müller, J M
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-01-01
- Volume
- 70
- Issue
- 1
- Pages
- 40-43
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2006847219
- Cited by
- 101
- References
- 20
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
- Keywords
- total parenteral nutrition, Crohn's disease, Crohn's disease recurrence, surgical resection, catheter-related sepsis, catheter embolism, intrahepatic cholestasis, short bowel syndrome, home parenteral nutrition, Broviac catheter
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Male, Nutritional Physiological Phenomena, Parenteral Nutrition, Parenteral Nutrition, Total, Prospective Studies, Recurrence
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