The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Total parenteral nutrition as the sole therapy in Crohn's disease—a prospective study
Abstract
The effect of total parenteral nutrition (TPN) as sole therapy was studied in 30 consecutive cases of complicated Crohn's disease. After insertion of a Broviac-type central venous catheter patients were nourished parenterally for 3 weeks in the hospital and then for an additional 9 weeks at home. During this time no medication or oral intake was allowed. Surgery was avoided in 25 patients by TPN. These patients returned to work, ate normal meals and needed no medical support. In 5 cases it was not possible to control the acute disease and the patients were treated by resection. During TPN, catheter-related sepsis occurred in 3 patients (0.9 cases/1000 days TPN) and catheter embolism in 2. Four other patients developed intrahepatic cholestasis. A relapse of Crohn's disease was observed in 17 cases 3-48 months after the course of TPN. The cumulative recurrence rate is 60 per cent after 2 years and 85 per cent after 4 years. Compared with the results of resection, obtained from a 10-year period before TPN was instituted at our hospital, the cumulative recurrence rate after TPN is four times higher. It is concluded that TPN is not an alternative to resection in the treatment of Crohn's disease and should be reserved for patients with multifocal lesions, when surgery is not advisable because of the risk of a short bowel syndrome.
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“In a prospective study of 30 patients with CD treated with bowel rest and TPN, 25 (83%) achieved initial remission, but relapse was common73.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [73]
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Metadata
- Authors
- Müller, J. M., Keller, H. W., Erasmi, H., & Pichlmaier, H.
- Affiliations
- University of Cologne (DE)
- ORCID
- Müller, J M
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-01-01
- Volume
- 70
- Issue
- 1
- Pages
- 40-43
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2006847219
- Cited by
- 101
- References
- 20
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
- Keywords
- total parenteral nutrition, Crohn's disease, Crohn's disease recurrence, surgical resection, catheter-related sepsis, catheter embolism, intrahepatic cholestasis, short bowel syndrome, home parenteral nutrition, Broviac catheter
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Male, Nutritional Physiological Phenomena, Parenteral Nutrition, Parenteral Nutrition, Total, Prospective Studies, Recurrence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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