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Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery
Abstract
Samples of ileal serosa and mesenteric lymph nodes have been harvested before antibiotic administration during 46 non-contaminated operations for Crohn's disease and compared with 43 operations for conditions other than Crohn's. Potentially pathogenic bacteria were isolated from the serosa in 12 (27 per cent) Crohn's patients, compared with 6 (15 per cent) controls (P = 0.04). Intestinal bacteria were recovered from mesenteric nodes in 15 (33 per cent) Crohn's patients compared with 2 (5 per cent) controls (P = 0.006). These findings suggest that bacteria leak from the small bowel lumen in a high proportion of Crohn's disease patients. This may explain the pathogenesis of abscess and fistula in this disorder as well as the high rate of sepsis following elective surgery even in the absence of macroscopic contamination.
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Citations
Cited by
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153
Bacterial translocation from the gastrointestinal tract
Berg, R. (1995) · Trends in Microbiology · doi:10.1016/s0966-842x(00)88906-4 · Cited by 444
Smith, A. M., Rahman, F. Z., Hayee, B., Graham, S. J., Marks, D. J. B., Sewell, G. W., Palmer, C. D., Wilde, J., Foxwell, B. M. J., Gloger, I. S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091233 · Cited by 398
Microbiology of bacterial translocation in humans
O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C. (1998) · Gut · doi:10.1136/gut.42.1.29 · Cited by 393
Metadata
- Authors
- Ambrose, N. S., Johnson, M., Burdon, D. W., & Keighley, M. R. B.
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-08-01
- Volume
- 71
- Issue
- 8
- Pages
- 623-625
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2165570349
- Cited by
- 195
- References
- 0
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. https://app.cochat.ai/papers/10.1002/bjs.1800710821
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- Ambrose, N. S., Johnson, M., Burdon, D. W., & Keighley, M. R. B. (1984). Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. Journal of British Surgery. https://doi.org/10.1002/bjs.1800710821
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
