Microbial Influences in Inflammatory Bowel Diseases

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Metagenomic Analysis of the Human Distal Gut Microbiome

Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works

Commensal Host-Bacterial Relationships in the Gut

Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works

Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,763 · see citing works

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works

Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10

Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513 · see citing works

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485 · see citing works

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works

Mucosal flora in inflammatory bowel disease

Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344 · see citing works

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329 · see citing works

The fundamental basis of inflammatory bowel disease

Strober, W., Fuss, I. J., & Mannon, P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30587 · Cited by 1,310 · see citing works

Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae

Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works

Maintaining remission of ulcerative colitis with the probiotic <i>Escherichia coli</i> Nissle 1917 is as effective as with standard mesalazine

Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156 · see citing works

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077 · see citing works

Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease

Assche, G. V., Ranst, M. A. V., Sciot, R., Dubois, B., Vermeire, S., Noman, M., Verbeeck, J., Geboes, K., Robberecht, W., & Rutgeerts, P. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051586 · Cited by 1,058 · see citing works

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.002 · Cited by 1,016 · see citing works

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 997 · see citing works

Reduced Paneth cell α-defensins in ileal Crohn's disease

Wehkamp, J., Salzman, N. H., Porter, E. M., Nuding, S., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M. G., Linzmeier, R. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505256102 · Cited by 988 · see citing works

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

Duchmann, R., Kaiser, I., Hermann, E., Mayet, W.-J., Ewe, K., & BÜSCHENFELDE, K.-H. M. Z. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03836.x · Cited by 938 · see citing works

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

Smythies, L. E., Sellers, M. T., Clements, R. H., Mosteller‐Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M., & Smith, P. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519229 · Cited by 924 · see citing works

The safety profile of infliximab in patients with Crohn’s disease: The Mayo Clinic experience in 500 patients

Colombel, J., Loftus, E. V., Tremaine, W. J., Egan, L. J., Harmsen, W. S., Schleck, C. D., Zinsmeister, A. R., & Sandborn, W. J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.047 · Cited by 898 · see citing works

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease

Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · see citing works

Toll-like Receptor 4 Is a Sensor for Autophagy Associated with Innate Immunity

Xu, Y., Jagannath, C., Liu, X.-D., Sharafkhaneh, A., Kolodziejska, K. E., & Eissa, N. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.022 · Cited by 880 · see citing works

Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum

D’Haens, G., Geboes, K., Peeters, M., Baert, F., PENNINCKX, F. M., & Rutgeerts, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70476-7 · Cited by 866 · see citing works

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

Darfeuille–Michaud, A., Neut, C., Barnich, N., Lederman, E., Martino, P. D., Desreumaux, P., Gambiez, L. P., Joly, B., Cortot, A., & Colombel, J.-F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70019-8 · Cited by 859 · see citing works

Signalling pathways and molecular interactions of NOD1 and NOD2

Strober, W., Murray, P. J., Kitani, A., & Watanabe, T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1747 · Cited by 856 · see citing works

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. (2000) · Science · doi:10.1126/science.289.5484.1560 · Cited by 843 · see citing works

NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses

Watanabe, T., Kitani, A., Murray, P. J., & Strober, W. (2004) · Nature Immunology · doi:10.1038/ni1092 · Cited by 839 · see citing works

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., Taurog, J. D., Hammer, R. E., Wilson, K. H., & Sartor, R. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118878 · Cited by 833 · see citing works

Influences of microbiota on intestinal immune system development.

Cebra, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1046s · Cited by 819 · see citing works

Bacterial flagellin is a dominant antigen in Crohn disease

Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M., & Hershberg, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420295 · Cited by 802 · see citing works

A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease

Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786 · see citing works

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

Rioux, J. D., Daly, M. J., Silverberg, M. S., Lindblad‐Toh, K., Steinhart, H., Cohen, Z., DelMonte, T. A., Kocher, K., Miller, K. L., Guschwan-McMahon, S., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-223 · Cited by 774 · see citing works

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works

Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection

Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90121-3 · Cited by 743 · see citing works

Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor

Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702 · see citing works

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice

Dieleman, L. A., Ridwan, B. U., Tennyson, G. S., Beagley, K. W., Bucy, R. P., & Elson, C. O. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90803-6 · Cited by 677 · see citing works

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

Hermiston, M. L., & Gordon, J. I. (1995) · Science · doi:10.1126/science.270.5239.1203 · Cited by 669 · see citing works

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632 · see citing works

Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease

Marchesi, J. R., Holmes, E. C., Khan, F. M. A., Kochhar, S., Scanlan, P. D., Shanahan, F., Wilson, I. D., & Wang, Y. (2007) · Journal of Proteome Research · doi:10.1021/pr060470d · Cited by 632 · see citing works

Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum

Baumgart, M., Dogan, B., Rishniw, M., Weitzman, G., Bosworth, B. P., Yantiss, R. K., Orsi, R. H., Wiedmann, M., McDonough, P. L., Kim, S. G., et al. (2007) · The ISME Journal · doi:10.1038/ismej.2007.52 · Cited by 630 · see citing works

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

Lee, J., Mo, J., Katakura, K., Alkalay, I., Rucker, A. N., Liu, Y., Lee, H., Shen, C., Cojocaru, G., Shenouda, S., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1500 · Cited by 621 · see citing works

Epithelial cells as sensors for microbial infection.

Kagnoff, M. F., & Eckmann, L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119522 · Cited by 619 · see citing works

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Barnich, N., Carvalho, F. A., Glasser, A.-L., Darcha, C., Jantscheff, P., Allez, M., Peeters, H., Bommelaer, G., Desreumaux, P., Colombel, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30504 · Cited by 590 · see citing works

Impact of Clostridium difficile on Inflammatory Bowel Disease

Issa, M., Vijayapal, A., Graham, M. B., Beaulieu, D. B., Otterson, M. F., Lundeen, S. J., Skaros, S., Weber, L. R., KOMOROWSKI, R. A., Knox, J. F., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.028 · Cited by 570 · see citing works

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis

Panwala, C. M., Jones, J. C., & Viney, J. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5733 · Cited by 567 · see citing works

A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the Colon

Fellermann, K., Stange, D. E., Schaeffeler, E., Schmalzl, H., Wehkamp, J., Bevins, C. L., Reinisch, W., Teml, A., Schwab, M. G., Lichter, P., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/505915 · Cited by 565 · see citing works

Differences between Tissue-Associated Intestinal Microfloras of Patients with Crohn's Disease and Ulcerative Colitis

Gophna, U., Sommerfeld, K., Gophna, S., Doolittle, W., & van Zanten, S. V. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01004-06 · Cited by 541 · see citing works

Crohn’s disease and the NOD2 gene: a role for paneth cells

Lala, S. G., Ogura, Y., Osborne, C., Hor, S. Y., Bromfield, A., Davies, S. E., Ogunbiyi, O. A., Núñez, G., & Keshav, S. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00661-9 · Cited by 528 · see citing works

Incidence of Clostridium difficile Infection in Inflammatory Bowel Disease

Rodemann, J. F., Dubberke, E. R., Reske, K. A., Seo, D. H., & Stone, C. D. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.027 · Cited by 520 · see citing works

Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease

Mow, W. S., Vasiliauskas, E. A., Lin, Y.-C., Fleshner, P. R., Papadakis, K. A., Taylor, K. D., Landers, C. J., Abreu-Martin, M. T., Rotter, J. I., Yang, H., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.015 · Cited by 517 · see citing works

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

Fukata, M., Michelsen, K. S., Eri, R. D., Thomas, L. S., Hu, B., Lukasek, K., Nast, C. C., Lechago, J., Xu, R., Naiki, Y., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2004 · Cited by 508 · see citing works

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496 · see citing works

Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA

Huycke, M. M., Abrams, V., & Moore, D. R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.529 · Cited by 489 · see citing works

Antibodies to CBir1 Flagellin Define a Unique Response That Is Associated Independently With Complicated Crohn’s Disease

Targan, S. R., Landers, C. J., Yang, H., Lodes, M. J., Cong, Y., Papadakis, K. A., Vasiliauskas, E., Elson, C. O., & Hershberg, R. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.046 · Cited by 476 · see citing works

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

Ízcue, A., Coombes, J. L., & Powrie, F. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00423.x · Cited by 473 · see citing works

Adherent Invasive Escherichia coli Strains from Patients with Crohn's Disease Survive and Replicate within Macrophages without Inducing Host Cell Death

Glasser, A.-L., Boudeau, J., Barnich, N., Perruchot, M.-H., Colombel, J., & Darfeuille–Michaud, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5529-5537.2001 · Cited by 465 · see citing works

Cox-2 Is Regulated by Toll-Like Receptor-4 (TLR4) Signaling: Role in Proliferation and Apoptosis in the Intestine

Fukata, M., Chen, A., Klepper, A. L., Krishnareddy, S., Vamadevan, A. S., Thomas, L. S., Xu, R., Inoue, H., Arditi, M., Dannenberg, A. J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.017 · Cited by 456 · see citing works

Toll-like receptor 9–induced type I IFN protects mice from experimental colitis

Katakura, K., Lee, J., Rachmilewitz, D., Li, G. C., Eckmann, L., & Raz, E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22996 · Cited by 450 · see citing works

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

Macpherson, A. J., Khoo, U. Y., Forgács, I., Philpott‐Howard, J., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.3.365 · Cited by 435 · see citing works

Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria

Kim, S. C., Tonkonogy, S. L., Albright, C. A., Tsang, J., Balish, E., Braun, J., Huycke, M. M., & Sartor, R. B. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.009 · Cited by 433 · see citing works

High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease

Kotłowski, R., Bernstein, C. N., Sepehri, S., & Krause, D. O. (2006) · Gut · doi:10.1136/gut.2006.099796 · Cited by 422 · see citing works

Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: A randomized, double-blind, placebo-controlled trial

Rutgeerts, P. J., Assche, G. V., Vermeire, S., D’Haens, G., Baert, F., Noman, M., Aerden, I., Hertogh, G. D., Geboes, K. J., Hiele, M. I., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.010 · Cited by 416 · see citing works

Endocarditis and biofilm-associated pili of Enterococcus faecalis

Nallapareddy, S. R., Singh, K. V., Sillanpää, J., Garsin, D. A., Höök, M., Erlandsen, S. L., & Murray, B. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29021 · Cited by 408 · see citing works

Microbiology of bacterial translocation in humans

O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C. (1998) · Gut · doi:10.1136/gut.42.1.29 · Cited by 393 · see citing works

Defective acute inflammation in Crohn's disease: a clinical investigation

Marks, D. J., Harbord, M., MacAllister, R. J., Rahman, F. Z., Young, J., Al‐Lazikani, B., Lees, W. R., Novelli, M. R., Bloom, S. L., & Segal, A. W. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68265-2 · Cited by 384 · see citing works

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

Cong, Y., Brandwein, S. L., McCabe, R. P., Lazenby, A., Birkenmeier, E. H., Sundberg, J. P., & Elson, C. O. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.855 · Cited by 383 · see citing works

Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease

Conte, M. P., Schippa, S., Zamboni, I., Penta, M., Chiarini, F., Seganti, L., Osborn, J., Falconieri, P., Borrelli, O., & Cucchiara, S. (2006) · Gut · doi:10.1136/gut.2005.078824 · Cited by 383 · see citing works

Early Postoperative Complications are not Increased in Patients with Crohn's Disease Treated Perioperatively with Infliximab or Immunosuppressive Therapy

Colombel, J., Loftus, E. V., Tremaine, W. J., Pembérton, J. H., Wolff, B. G., Young‐Fadok, T. M., Harmsen, W. S., Schleck, C. D., & Sandborn, W. J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04148.x · Cited by 381 · see citing works

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Becker, C., Wirtz, S. J., Blessing, M., Pirhonen, J., Strand, D. J., Bechthold, O., Frick, J., Galle, P. R., Autenrieth, I. B., & Neurath, M. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17464 · Cited by 360 · see citing works

Two-Year Combination Antibiotic Therapy With Clarithromycin, Rifabutin, and Clofazimine for Crohn’s Disease

Selby, W. S., Pavli, P., Crotty, B. J., Florin, T., Radford‐Smith, G. L., Gibson, P. G., Mitchell, B., Connell, W., Read, R. B., Merrett, M. N., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.031 · Cited by 360 · see citing works

β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells

Vora, P., Youdim, A., Thomas, L. S., Fukata, M., Tesfay, S., Lukasek, K., Michelsen, K. S., Wada, A., Hirayama, T., Arditi, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5398 · Cited by 358 · see citing works

Mucosal and Invading Bacteria in Patients with Inflammatory Bowel Disease Compared with Controls

Kleessen, B., Kroesen, A. J., Buhr, H. J., & Blaut, M. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202320378220 · Cited by 351 · see citing works

Crohn's disease and the mycobacterioses: a review and comparison of two disease entities

Chiodini, R. J. (1989) · Clinical Microbiology Reviews · doi:10.1128/cmr.2.1.90 · Cited by 346 · see citing works

Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice

Rath, H. C., Schultz, M., Freitag, R., Dieleman, L. A., Li, F., Linde, H., Schölmerich, J., & Sartor, R. B. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2277-2285.2001 · Cited by 342 · see citing works

Possible role of mycobacteria in inflammatory bowel disease

Chiodini, R. J., Kruiningen, H. J. V., Thayer, W. R., Merkal, R. S., & Coutu, J. A. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01317078 · Cited by 332 · see citing works

Culture-Independent Analyses of Temporal Variation of the Dominant Fecal Microbiota and Targeted Bacterial Subgroups in Crohn's Disease

Scanlan, P. D., Shanahan, F., O'Mahony, C., & Marchesi, J. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00312-06 · Cited by 330 · see citing works

Anti- Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease

Israeli, E., Grotto, I., Gilburd, B., Balicer, R. D., Goldin, E., Wiik, A., & Shoenfeld, Y. (2005) · Gut · doi:10.1136/gut.2004.060228 · Cited by 322 · see citing works

Interleukin-10 Gene-Deficient Mice Develop a Primary Intestinal Permeability Defect in Response to Enteric Microflora

Madsen, K. L., Malfair, D., Gray, D., Doyle, J. S. G., Jewell, L. D., & Fedorak, R. N. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00004 · Cited by 318 · see citing works

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Becker, C., Wirtz, S. J., Blessing, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317464 · Cited by 318 · see citing works

Reducing sulfur compounds of the colon impair colonocyte nutrition: Implications for ulcerative colitis

Roediger, W. E. W., Duncan, A. J., Kapaniris, O., & Millard, S. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91016-b · Cited by 317 · see citing works

Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

Yamada, T., Deitch, E. A., Specian, R. D., Perry, M. A., Sartor, R. B., & Grisham, M. B. (1993) · Inflammation · doi:10.1007/bf00920471 · Cited by 316 · see citing works

Risk Factors for Intra-Abdominal Septic Complications After a First Ileocecal Resection for Crohn's Disease: A Multivariate Analysis in 161 Consecutive Patients

Alvès, A., Panis, Y. H., Bouhnik, Y., et al. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0782-0 · Cited by 314 · see citing works

Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence<i>in situ</i>hybridization study in mice

Swidsinski, A. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i8.1131 · Cited by 314 · see citing works

Immunocytochemical evidence of Listeria, Escherichia coil, and Streptococcus antigens in Crohn's disease

Liu, Y., Kruiningen, H. J. V., West, A. B., Cartun, R. W., Cortot, A., & Colombel, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90687-8 · Cited by 290 · see citing works

Serum Immune Responses Predict Rapid Disease Progression among Children with Crohn's Disease: Immune Responses Predict Disease Progression

Dubinsky, M. C., Lin, Y.-C., Dutridge, D., Picornell, Y., Landers, C. J., Farrior, S., Wrobel, I. T., Quiros, A., Vasiliauskas, E. A., Grill, B. B., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00456.x · Cited by 286 · see citing works

The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4

Wehkamp, J., Wang, G., Kübler, I., Nuding, S., Gregorieff, A., Schnabel, A., Kays, R. J., Fellermann, K., Burk, O., Schwab, M. G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3109 · Cited by 286 · see citing works

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases

Pierik, M. J., Joossens, S. B. A., Steen, K. V., Schuerbeek, N. V., VLIETINCK, R. F., Rutgeerts, P., & Vermeire, S. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195389.11645.ab · Cited by 280 · see citing works

IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows' milk in England and Wales

Millar, D., Ford, J., Sanderson, J. D., et al. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.9.3446-3452.1996 · Cited by 280 · see citing works

Expression of Interleukin-12-Related Cytokine Transcripts in Inflammatory Bowel Disease: Elevated Interleukin-23p19 and Interleukin-27p28 in Crohnʼs Disease But Not in Ulcerative Colitis

Schmidt, C., Giese, T., Ludwig, B., Mueller-Molaian, I., Marth, T., Zeuzem, S., Meuer, S. C., & Stallmach, A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200501000-00003 · Cited by 279 · see citing works

Adherent and InvasiveEscherichia coliIs Associated with Granulomatous Colitis in Boxer Dogs

Simpson, K. W., Dogan, B., Rishniw, M., Goldstein, R. E., Klaessig, S., McDonough, P. L., German, A. J., Yates, R. M., Russell, D. G., Johnson, S. E., et al. (2006) · Infection and Immunity · doi:10.1128/iai.00067-06 · Cited by 278 · see citing works

Differential Induction of Colitis and Gastritis in HLA-B27 Transgenic Rats Selectively Colonized with Bacteroides vulgatus or Escherichia coli

Rath, H. C., Wilson, K. H., & Sartor, R. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2969-2974.1999 · Cited by 276 · see citing works

Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease

Neut, C., Bulois, P., Desreumaux, P., Membré, J., Lederman, E., Gambiez, L. P., Cortot, A., Quandalle, P. A., Kruiningen, H. J. V., & Colombel, J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05613.x · Cited by 274 · see citing works

Abnormal microbiota composition in the ileocolonic mucosa of Crohnʼs disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis

Martínez-Medina, M., Aldeguer, X., Gónzalez‐Huix, F., Acero, D., & Garcia-Gil, L. J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235828.09305.0c · Cited by 263 · see citing works

Probiotics for maintenance of remission in Crohn's disease

Rolfe, V. E., Fortun, P., Hawkey, C. J., & Bath-Hextall, F. J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004826.pub2 · Cited by 252 · see citing works

Invasive Escherichia coli are a feature of Crohn's disease

Sasaki, M., Sitaraman, S. V., Babbin, B. A., Gerner‐Smidt, P., Ribot, E. M., Garrett, N. A., Alpern, J. A., Akyildiz, A., Theiss, A. L., Nusrat, A., et al. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700661 · Cited by 243 · see citing works

Higher Incidence of Abnormal Pap Smears in Women With Inflammatory Bowel Disease

Kane, S. V., Khatibi, B., & Reddy, D. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01582.x · Cited by 241 · see citing works

Possible role of Mycobacteria in inflammatory bowel disease

Thayer, W. R., Coutu, J. A., Chiodini, R. J., Kruiningen, H. J. V., & Merkal, R. S. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01317079 · Cited by 226 · see citing works

The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients

Bibiloni, R., Mangold, M., Madsen, K. L., Fedorak, R. N., & Tannock, G. W. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46498-0 · Cited by 226 · see citing works

Isolation of Mycobacterium avium subsp paratuberculosis from breast milk of Crohn's disease patients

Naser, S. A., Schwartz, D., & Shafran, I. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01954.x · Cited by 222 · see citing works

Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4

Heimesaat, M. M., Fischer, A., Siegmund, B., Kupz, A., Niebergall, J., Fuchs, D., Jahn, H.-K., Freudenberg, M., Loddenkemper, C., Batra, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000662 · Cited by 213 · see citing works

Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials

Hedin, C. R. H., Whelan, K., & Lindsay, J. O. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005563 · Cited by 211 · see citing works

Candida albicans Is an Immunogen for Anti–Saccharomyces cerevisiae Antibody Markers of Crohn’s Disease

Standaert‐Vitse, A., Jouault, T., Vandewalle, P., Mille, C., Seddik, M., Sendid, B., Mallet, J., Colombel, J., & Poulain, D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.009 · Cited by 210 · see citing works

Bacterial-Reactive T Regulatory Cells Inhibit Pathogenic Immune Responses to the Enteric Flora

Cong, Y., Weaver, C. T., Lazenby, A. J., & Elson, C. O. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6112 · Cited by 209 · see citing works

Anti-inflammatory properties of<i>Lactobacillus gasseri</i>expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis

Carroll, I. M., Andrus, J. M., Bruno-Bárcena, J. M., Klaenhammer, T. R., Hassan, H. M., & Threadgill, D. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00132.2007 · Cited by 208 · see citing works

TLRs in the Gut.IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction

Shibolet, O., & Podolsky, D. K. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00531.2006 · Cited by 208 · see citing works

Type 1 pili‐mediated adherence of Escherichia coli strain LF82 isolated from Crohn's disease is involved in bacterial invasion of intestinal epithelial cells

Boudeau, J., Barnich, N., & Darfeuille–Michaud, A. (2001) · Molecular Microbiology · doi:10.1111/j.1365-2958.2001.02315.x · Cited by 206 · see citing works

The Role of Microbes in Crohn's Disease

Eckburg, P. B., & Relman, D. A. (2006) · Clinical Infectious Diseases · doi:10.1086/510385 · Cited by 206 · see citing works

Cytomegalovirus Is Frequently Reactivated and Disappears Without Antiviral Agents in Ulcerative Colitis Patients

Matsuoka, K., Iwao, Y., Mori, T., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00989.x · Cited by 202 · see citing works

IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation

Schultz, M., Tonkonogy, S. L., Sellon, R. K., Veltkamp, C., Godfrey, V., Kwon, J., Grenther, W. B., Balish, E., Horak, I. D., & Sartor, R. B. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.6.g1461 · Cited by 200 · see citing works

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

Ho, G., Nimmo, E. R., Tenesa, A., Fennell, J., Drummond, H. E., Mowat, C., Arnott, I., & Satsangi, J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.019 · Cited by 196 · see citing works

Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery

Ambrose, N. S., Johnson, M., Burdon, D. W., & Keighley, M. R. B. (1984) · British journal of surgery · doi:10.1002/bjs.1800710821 · Cited by 195 · see citing works

High prevalence of Mycobacterium avium subspecies paratuberculosis IS 900 DNA in gut tissues from individuals with Crohn’s disease

Autschbach, F., Eisold, S., Hinz, U., Zinser, S., Linnebacher, M., Giese, T., Löffler, T., Büchler, M. W., & Schmidt, J. (2005) · Gut · doi:10.1136/gut.2004.045526 · Cited by 193 · see citing works

IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium

Egan, L. J., Eckmann, L., Greten, F. R., Chae, S.-W., Li, Z.-W., Myhre, G. M., Robine, S., Karin, M., & Kagnoff, M. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306734101 · Cited by 192 · see citing works

Defects in mucosal immunity leading to ulcerative colitis

Targan, S. R., & Karp, L. C. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00286.x · Cited by 191 · see citing works

Abundant and Diverse Fungal Microbiota in the Murine Intestine

Scupham, A. J., Presley, L. L., Wei, B., Bent, E., Griffith, N., McPherson, M., Zhu, F., Oluwadara, O., Rao, N. P., Braun, J. G., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.1.793-801.2006 · Cited by 185 · see citing works

On the etiology of Crohn disease.

Mishina, D., Katsel, P., Brown, S. T., Gilberts, E. C. A. M., & Greenstein, R. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9816 · Cited by 183 · see citing works

TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium

Lebeis, S. L., Bommarius, B., Parkos, C. A., Sherman, M. A., & Kalman, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.566 · Cited by 176 · see citing works

Does Mycobacterium avium subspecies paratuberculosis cause Crohn’s disease?: Table 1

Sartor, R. B. (2005) · Gut · doi:10.1136/gut.2004.055889 · Cited by 173 · see citing works

The primary defect in experimental ileitis originates from a nonhematopoietic source

Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172 · see citing works

Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease

Hilsden, R. J., Meddings, J., & Sutherland, L. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613043 · Cited by 169 · see citing works

Dextran Sodium Sulfate-Induced Colitis in Germ-Free IQI/Jic Mice.

Kitajima, S., MORIMOTO, M., Sagara, E., SHIMIZU, C., & IKEDA, Y. (2001) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.50.387 · Cited by 168 · see citing works

Probiotic Effects on Inflammatory Bowel Disease1,

Sheil, B., Shanahan, F., & O’Mahony, L. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.819s · Cited by 167 · see citing works

Bacterial DNA within Granulomas of Patients with Crohn's Disease-Detection by Laser Capture Microdissection and PCR

Ryan, P. M., Kelly, R., Lee, G., Collins, J. K., O’Sullivan, G. C., O’Connell, J., & Shanahan, F. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40103.x · Cited by 167 · see citing works

Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments

Sartor, R. B., Cromartie, W. J., Powell, D. W., & Schwab, J. H. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90455-x · Cited by 166 · see citing works

Reduced mucosal antimicrobial activity in Crohn’s disease of the colon

Nuding, S., Fellermann, K., Wehkamp, J., & Stange, E. F. (2007) · Gut · doi:10.1136/gut.2006.118646 · Cited by 163 · see citing works

Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics

Gui, G. P., Thomas, P. R., Tizard, M. L., et al. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/39.3.393 · Cited by 163 · see citing works

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease☆

Kraus, T., Toy, L. S., Chan, L., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.076 · Cited by 159 · see citing works

Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction.

Wannemuehler, M. J., Kiyono, H., Babb, J. L., Michalek, S. M., & McGhee, J. R. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.3.959 · Cited by 155 · see citing works

Adherent-invasive Escherichia coli and Crohnʼs disease

Barnich, N., & Darfeuille–Michaud, A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280105a38 · Cited by 155 · see citing works

Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tgϵ26 mice

Veltkamp, C., Tonkonogy, S. L., de Jong, Y. P., Albright, C. A., Grenther, W. B., Balish, E., Terhorst, C., & Sartor, R. B. (2001) · Gastroenterology · doi:10.1053/gast.2001.22547 · Cited by 148 · see citing works

Enterotoxigenic Bacteroides fragilis: A potential instigator of colitis

Rabizadeh, S., Rhee, K., Wu, S., Huso, D. L., Gan, C. M., Golub, J. E., Wu, X., Zhang, M., & Sears, C. L. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20265 · Cited by 147 · see citing works

CARD15/NOD2 Is Required for Peyer's Patches Homeostasis in Mice

Barreau, F., Meinzer, U., Chareyre, F., Berrebi, D. D., Niwa‐Kawakita, M., Dussaillant, M., Foligné, B., Ollendorff, V., Heyman, M., Bonacorsi, S., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000523 · Cited by 144 · see citing works

STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells

Hoentjen, F., Sartor, R. B., Ozaki, M., & Jobin, C. (2004) · Blood · doi:10.1182/blood-2004-04-1309 · Cited by 143 · see citing works

Risks and Benefits of Infliximab for the Treatment of Crohn’s Disease

Siegel, C. A., Hur, C., Korzenik, J. R., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.05.020 · Cited by 142 · see citing works

Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways

Zeng, H., Wu, H., Sloane, V. M., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00273.2005 · Cited by 136 · see citing works

Dual-association of gnotobiotic Il-10−/− mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis

Kim, S. C., Tonkonogy, S. L., Karrasch, T., Jobin, C., & Sartor, R. B. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20246 · Cited by 131 · see citing works

Bile salts enhance bacterial co-aggregation, bacterial-intestinal epithelial cell adhesion, biofilm formation and antimicrobial resistance of Bacteroides fragilis

Pumbwe, L., Skilbeck, C. A., Nakano, V., Ávila-Campos, M. J., Piazza, R. M. F., & Wexler, H. M. (2007) · Microbial Pathogenesis · doi:10.1016/j.micpath.2007.04.002 · Cited by 128 · see citing works

Transforming Growth Factor-β1 Inhibits Non-pathogenic Gramnegative Bacteria-induced NF-κB Recruitment to the Interleukin-6 Gene Promoter in Intestinal Epithelial Cells through Modulation of Histone Acetylation

Haller, D., Holt, L. C., Kim, S. C., Schwabe, R. F., Sartor, R. B., & Jobin, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300075200 · Cited by 127 · see citing works

OmpC and the σE regulatory pathway are involved in adhesion and invasion of the Crohn's disease‐associated Escherichia coli strain LF82

Rolhion, N., Carvalho, F. A., & Darfeuille–Michaud, A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05638.x · Cited by 125 · see citing works

Improvement of an experimental colitis in rats by lactic acid bacteria producing superoxide dismutase

Han, W., Mercenier, A., Ait-Belgnaoui, A., Pavan, S., Lamine, F., van Swam, I. I., Kleerebezem, M., Salvador–Cartier, C., Hisbergues, M., Bueno, L. P., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235101.09231.9e · Cited by 121 · see citing works

Maintenance infliximab does not result in increased abscess development in fistulizing Crohn's disease: results from the ACCENT II study

Sands, B. E., BLANK, M. A., Diamond, R. H., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02878.x · Cited by 121 · see citing works

Incidence and Microbiology of Abdominal and Pelvic Abscess in Crohn's Disease

Keighley, M. R. B., Eastwood, D., Ambrose, N. S., et al. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80139-x · Cited by 117 · see citing works

NOD2 Variants and Antibody Response to Microbial Antigens in Crohn’s Disease Patients and Their Unaffected Relatives

Devlin, S. M., Yang, H., Ippoliti, A., Taylor, K. D., Landers, C. J., Su, X., Abreu, M. T., Papadakis, K. A., Vasiliauskas, E. A., MELMED, G. Y., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.013 · Cited by 117 · see citing works

Gnotobiotic IL-10−/−;NF-κBEGFP Mice Reveal the Critical Role of TLR/NF-κB Signaling in Commensal Bacteria-Induced Colitis

Karrasch, T., Kim, J.-S., Mühlbauer, M., Magness, S. T., & Jobin, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6522 · Cited by 117 · see citing works

Anti-flagellin (CBir1) phenotypic and genetic Crohnʼs disease associations

Papadakis, K. A., Yang, H., Ippoliti, A., Mei, L., Elson, C. O., Hershberg, R. M., Vasiliauskas, E. A., Fleshner, P. R., Abreu, M. T., Taylor, K. D., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20106 · Cited by 113 · see citing works

Strong Decrease in Invasive Ability and Outer Membrane Vesicle Release in Crohn's Disease-Associated Adherent-Invasive Escherichia coli Strain LF82 with the yfgL Gene Deleted

Rolhion, N., Barnich, N., Claret, L., et al. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.7.2286-2296.2005 · Cited by 111 · see citing works

pANCA Represents a Cross-Reactivity to Enteric Bacterial Antigens

Seibold, F., Brandwein, S. R., Simpson, S., et al. (1998) · Journal of Clinical Immunology · doi:10.1023/a:1023203118100 · Cited by 107 · see citing works

Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice

Hoentjen, F., Harmsen, H. J. M., Braat, H., Torrice, C. D., Mann, B. A., Sartor, R. B., & Dieleman, L. A. (2003) · Gut · doi:10.1136/gut.52.12.1721 · Cited by 107 · see citing works

Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: Implications for chronic inflammation

Clavel, T., & Haller, D. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20174 · Cited by 105 · see citing works

An immunocytochemical search for infectious agents in Crohn's disease.

Cartun, R. W., Kruiningen, H. J. V., Pedersen, C. A., et al. (1993) · PubMed · Cited by 104 · see citing works

Stimulation of transforming growth factor β1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis

Mourelle, M., Salas, A., Guarner, F., Crespo, E., Garcia-Lafuente, A. M., & Malagelada, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70535-9 · Cited by 98 · see citing works

Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: A randomized, controlled pilot trial with long-term follow-up

Ohkusa, T., Nomura, T., Terai, T., Miwa, H., Kobayashi, O., Hojo, M., Takei, Y., Ogihara, T., Hirai, S., Okayasu, I., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023648 · Cited by 93 · see citing works

Probiotics in the Treatment of Inflammatory Bowel Disease

Rioux, K. P., & Fedorak, R. N. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00019 · Cited by 90 · see citing works

Commensal Bacteria Exacerbate Intestinal Inflammation but Are Not Essential for the Development of Murine Ileitis

Bamias, G., Okazawa, A., Rivera–Nieves, J., Arseneau, K. O., Rue, S. A. D. L., Pizarro, T. T., & Cominelli, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1809 · Cited by 88 · see citing works

Recommendations for Probiotic Use

Floch, M. H., Madsen, K., Jenkins, D. J. A., Guandalini, S., Katz, J. A., Onderdonk, A. B., Walker, W. A., Fedorak, R. N., & Camilleri, M. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00022 · Cited by 88 · see citing works

Familial Expression of Anti-Escherichia coli Outer Membrane Porin C in Relatives of Patients With Crohn’s Disease

Mei, L., Targan, S. R., Landers, C. J., Dutridge, D., Ippoliti, A., Vasiliauskas, E. A., Papadakis, K. A., Fleshner, P. R., Rotter, J. I., & Yang, H. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.013 · Cited by 88 · see citing works

Clostridium Difficile-Associated Pouchitis

Shen, B., Goldblum, J. R., Hull, T. L., Remzi, F. H., Bennett, A. E., & Fazio, V. W. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9172-7 · Cited by 80 · see citing works

Enterohepatic circulation of bacterial chemotactic peptide in rats with experimental colitis

Hobson, C. H., Butt, T. J., Ferry, D. M., Hunter, J., CHADWICK, V. S., & Broom, M. F. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90560-4 · Cited by 79 · see citing works

Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury

Sartor, R. B., Bond, T., & Schwab, J. H. (1988) · Infection and Immunity · doi:10.1128/iai.56.8.2101-2108.1988 · Cited by 75 · see citing works

A Case-Control Study of Drinking Water and Dairy Products in Crohn's Disease--Further Investigation of the Possible Role of Mycobacterium avium paratuberculosis

Abubakar, I., Myhill, D., Hart, A. R., LAKE, I. R., Harvey, I. M., Rhodes, J. M., Robinson, R., Lobo, A., Probert, C. S., & Hunter, P. R. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk067 · Cited by 75 · see citing works

Is Crohn’s disease due to defective immunity?

Korzenik, J. R. (2006) · Gut · doi:10.1136/gut.2006.095588 · Cited by 72 · see citing works

Cdcs1, a Major Colitogenic Locus in Mice, Regulates Innate and Adaptive Immune Response to Enteric Bacterial Antigens

Beckwith, J., Cong, Y., Sundberg, J. P., Elson, C. O., & Leiter, E. H. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.07.057 · Cited by 72 · see citing works

Does Cross-Reactivity Between Mycobacterium avium paratuberculosis and Human Intestinal Antigens Characterize Crohn’s Disease?

Polymeros, D., Bogdanos, D. P., Day, R. M., Arioli, D., Vergani, D., & Forbes, A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.021 · Cited by 66 · see citing works

Cytomegalovirus infection in ulcerative colitis

Kojima, T., Watanabe, T., Hata, K., et al. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500408584 · Cited by 66 · see citing works

Inflammation and Apoptosis in Clostridium difficile Enteritis Is Mediated by PGE2 Up-Regulation of Fas Ligand

Kim, H., Rhee, S. H., Pothoulakis, C., & LaMont, J. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.063 · Cited by 63 · see citing works

Analysis of the large bowel microbiota of colitic mice using PCR/DGGE

Bibiloni, R., Simon, M. A., Albright, C. A., Sartor, B. R., & Tannock, G. W. (2005) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2005.01720.x · Cited by 61 · see citing works

Piroxicam Treatment of Il-10-Deficient Mice Enhances Colonic Epithelial Apoptosis and Mucosal Exposure to Intestinal Bacteria

Hale, L. P., Gottfried, M. R., & Swidsinski, A. V. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000187582.90423.bc · Cited by 60 · see citing works

A characterization of anaerobic colonization and associated mucosal adaptations in the undiseased ileal pouch

Smith, F. M., Coffey, J. C., Kell, M., et al. (2005) · Colorectal Disease · doi:10.1111/j.1463-1318.2005.00833.x · Cited by 58 · see citing works

Relationship between Crohn’s disease, infection withMycobacterium aviumsubspeciesparatuberculosisandSLC11A1gene polymorphisms in Sardinian patients

Sechi, L. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i44.7161 · Cited by 58 · see citing works

Colonic bacteria and bacterial translocation in experimental colitis

Gardiner, K. R., Erwin, P. J., Anderson, N. H., Barr, J., HALLIDAY, M. I., & Rowlands, B. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800436 · Cited by 57 · see citing works

Mycobacteria in Crohnʼs disease: A persistent hypothesis

Behr, M. A., & Schurr, E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000228183.70197.dd · Cited by 54 · see citing works

A possible link between Crohn’s disease and ankylosing spondylitis via Klebsiella infections

Ebringer, A., Rashid, T., Tiwana, H., et al. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0391-2 · Cited by 52 · see citing works

Antibodies to I2 predict clinical response to fecal diversion in Crohnʼs disease

Spivak, J., Landers, C. J., Vasiliauskas, E. A., Abreu, M. T., Dubinsky, M. C., Papadakis, K. A., Ippoliti, A., Targan, S. R., & Fleshner, P. R. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235833.47423.d7 · Cited by 52 · see citing works

High-Level Serum Antibodies to Bacterial Antigens Are Associated with Antibiotic-Induced Clinical Remission in Crohn's Disease: A Pilot Study

Mow, W. S., Landers, C. J., Steinhart, A. H., Feagan, B. G., Croitoru, K., Seidman, E. G., Greenberg, G. R., & Targan, S. R. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000037824.66186.e2 · Cited by 51 · see citing works

Mycobacterium avium subsp. paratuberculosis , Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead

Sechi, L. A., Gazouli, M., Ikonomopoulos, J., Lukas, J. C., Scanu, A. M., Ahmed, N., Fadda, G., & Zanetti, S. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5275-5277.2005 · Cited by 49 · see citing works

Wound‐induced p38MAPK‐dependent histone H3 phosphorylation correlates with increased COX‐2 expression in enterocytes

Karrasch, T., Steinbrecher, K. A., Allard, B., Baldwin, A. S., & Jobin, C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20626 · Cited by 47 · see citing works

IL‐10 Gene‐Deficient Mice Lack TGF‐Beta/Smad‐Mediated TLR2 Degradation and Fail to Inhibit Proinflammatory Gene Expression in Intestinal Epithelial Cells under Conditions of Chronic Inflammation

Ruiz, P. A., Shkoda, A., Kim, S. C., Sartor, R. B., & Haller, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.023 · Cited by 45 · see citing works

Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis

Sokol, H., Lepage, P., Seksik, P., et al. (2006) · Gut · doi:10.1136/gut.2006.109686 · Cited by 45 · see citing works

T cell-mediated oral tolerance is intact in germ-free mice

Walton, K. L. W., Galanko, J. A., Sartor, R. B., & Fisher, N. C. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03019.x · Cited by 38 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

Gut microbiota in health and disease

Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Role of the normal gut microbiota

Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001 · see citing works

Inflammation and Colon Cancer

Terzić, J., Grivennikov, S., Karin, E., & Karin, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.058 · Cited by 1,974 · see citing works

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works

Unravelling the effects of the environment and host genotype on the gut microbiome

Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509 · see citing works

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works

The gut microbiota in IBD

Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works

Enteric defensins are essential regulators of intestinal microbial ecology

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., et al. (2010) · Nature Immunology · doi:10.1038/ni.1825 · Cited by 1,156 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives

Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut · doi:10.1136/gut.2010.223263 · Cited by 1,063 · see citing works

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

Willing, B. P., Dicksved, J., Halfvarson, J., Andersson, A. F., Lucio, M., Zheng, Z., Järnerot, G., Tysk, C., Jansson, J. K., & Engstrand, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.049 · Cited by 1,032 · see citing works

Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis

Kassam, Z., Lee, C. H., Yuan, Y., & Hunt, R. H. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.59 · Cited by 904 · see citing works

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B. (2012) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2012.10.012 · Cited by 836 · see citing works

Toward defining the autoimmune microbiome for type 1 diabetes

Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Novelo, L. L., Casella, G., Drew, J. C., Ilonen, J., Knip, M., Hyöty, H., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.92 · Cited by 806 · see citing works

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works

Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome

Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771 · see citing works

Commensal clostridia: Leading players in the maintenance of gut homeostasis

Lopetuso, L. R., Scaldaferri, F., Petito, V., & Gasbarrini, A. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-23 · Cited by 753 · see citing works

Intestinal microbiota in human health and disease: the impact of probiotics

Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes &amp; Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549 · see citing works

Nod2 is required for the regulation of commensal microbiota in the intestine

Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564 · see citing works

Anticancer effects of the microbiome and its products

Zitvogel, L., Daillère, R., Roberti, M. P., Routy, B., & Kroemer, G. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.44 · Cited by 538 · see citing works

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

Alexeev, E. E., Lanis, J. M., Kao, D. J., Campbell, E. L., Kelly, C. J., Battista, K. D., Gerich, M. E., Jenkins, B. R., Walk, S. T., Kominsky, D. J., et al. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.01.011 · Cited by 532 · see citing works

Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children With Ulcerative Colitis

Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517 · see citing works

Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria

Fu, X., Liu, Z., Zhu, C., Mou, H., & Kong, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1542587 · Cited by 497 · see citing works

Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease

Wang, W., Chen, L., Zhou, R., Wang, X., Song, L., Huang, S., Wang, G., & Xia, B. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01500-13 · Cited by 509 · see citing works

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases

Peterson, D. A., Frank, D. N., Pace, N. R., & Gordon, J. I. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.05.001 · Cited by 503 · see citing works

An update on the use and investigation of probiotics in health and disease

Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A. (2013) · Gut · doi:10.1136/gutjnl-2012-302504 · Cited by 503 · see citing works

Probiotic <i>L. reuteri</i> Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

Britton, R. A., Irwin, R., Quach, D., Schaefer, L., Zhang, J., Lee, T., Parameswaran, N., & McCabe, L. R. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24636 · Cited by 499 · see citing works

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488 · see citing works

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447 · see citing works

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455 · see citing works

Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas

Shen, X. J., Rawls, J. F., Randall, T. A., Burcall, L., Mpande, C., Jenkins, N., Jovov, B., Abdo, Z., Sandler, R. S., & Keku, T. O. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12360 · Cited by 418 · see citing works

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Meisel, M., Hinterleitner, R., Pacis, A., Chen, L., Earley, Z. M., Mayassi, T., Pierre, J. F., Ernest, J. D., Galipeau, H. J., Thuille, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0125-z · Cited by 406 · see citing works

Lipocalin 2 protects from inflammation and Tumorigenesis associated with gut microbiota alterations

Moschen, A. R., Gerner, R. R., Wang, J., Klepsch, V., Adolph, T. E., Reider, S. J., Hackl, H., Pfister, A., Schilling, J., Moser, P. L., et al. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.03.007 · Cited by 375 · see citing works

Gut microbiota in autism and mood disorders

Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413 · see citing works

A prospective population-based study of triggers of symptomatic flares in IBD

Bernstein, C. N., Singh, S., Graff, L. A., Walker, J. R., Miller, N., & Cheang, M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.140 · Cited by 400 · see citing works

Mucin-type O-glycans and their roles in intestinal homeostasis

Bergstrom, K. S. B., & Xia, L. (2013) · Glycobiology · doi:10.1093/glycob/cwt045 · Cited by 360 · see citing works

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease

Benjamin, J. L., Hedin, C. R. H., Koutsoumpas, A., Ng, S. C., McCarthy, N. E., Hart, A. L., Kamm, M. A., Sanderson, J. D., Knight, S. C., Forbes, A., et al. (2011) · Gut · doi:10.1136/gut.2010.232025 · Cited by 361 · see citing works

Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease

Zhang, M., Sun, K., Wu, Y., Yang, Y., Tso, P., & Wu, Z. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00942 · Cited by 347 · see citing works

Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome

Le Gall, G., Noor, S. O., Ridgway, K., Scovell, L., Jamieson, C., Johnson, I. T., Colquhoun, I. J., Kemsley, E. K., & Narbad, A. (2011) · Journal of Proteome Research · doi:10.1021/pr2003598 · Cited by 348 · see citing works

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function

Patel, R. M., Myers, L. S., Kurundkar, A. R., Maheshwari, A., Nusrat, A., & Lin, P. W. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.025 · Cited by 341 · see citing works

Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation

Steck, N., Hoffmann, M., Sava, I. G., Kim, S. C., Hahne, H., Tonkonogy, S. L., Mair, K., Krueger, D., Pruteanu, M., Shanahan, F., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.05.035 · Cited by 343 · see citing works

Rebuilding the Gut Microbiota Ecosystem

Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081679 · Cited by 340 · see citing works

Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases

Packey, C. D., & Sartor, R. B. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832a8a5d · Cited by 319 · see citing works

Decreased abundance of <i> <scp>F</scp> aecalibacterium prausnitzii </i> in the gut microbiota of <scp>C</scp> rohn's disease

Fujimoto, T., Imaeda, H., Takahashi, K., Kasumi, E., Bamba, S., Fujiyama, Y., & Andoh, A. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12073 · Cited by 304 · see citing works

The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology

Kleiman, S. C., Watson, H. J., Bulik-Sullivan, E. C., Huh, E. Y., Tarantino, L. M., Bulik, C. M., & Carroll, I. M. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000247 · Cited by 303 · see citing works

Evaluation of 16S rDNA-Based Community Profiling for Human Microbiome Research

Jumpstart Consortium Human Microbiome Project Data Generation Working Group (2012) · PLoS ONE · doi:10.1371/journal.pone.0039315 · Cited by 297 · see citing works

Food, immunity, and the microbiome

Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works

Gut microbiota and gastrointestinal health: current concepts and future directions

Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12046 · Cited by 280 · see citing works

Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis

Hernández-Chirlaque, C., Aranda, C. J., Ocón, B., Capitán-Cañadas, F., Ortega-González, M., Carrero, J. J., Suárez, M. D., Zarzuelo, A., Sánchez de Medina, F., & Martínez-Augustin, O. (2016) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjw096 · Cited by 262 · see citing works

Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis

Kump, P. K., Gröchenig, H.-P., Lackner, S., Trajanoski, S., Reicht, G., Hoffmann, K. M., Deutschmann, A., Wenzl, H. H., Petritsch, W., Krejs, G. J., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31829ea325 · Cited by 235 · see citing works

The non-pathogenic <i>Escherichia coli</i> strain Nissle 1917 – features of a versatile probiotic

Sonnenborn, U., & Schulze, J. (2009) · Microbial Ecology in Health and Disease · doi:10.3109/08910600903444267 · Cited by 232 · see citing works

Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota

Noor, S. O., Ridgway, K., Scovell, L., Kemsley, E. K., Lund, E. K., Jamieson, C., Johnson, I. T., & Narbad, A. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-134 · Cited by 227 · see citing works

Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome

Shimizu, K., Ogura, H., Hamasaki, T., Goto, M., Tasaki, O., Asahara, T., Nomoto, K., Morotomi, M., Matsushima, A., Kuwagata, Y., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1418-8 · Cited by 213 · see citing works

A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients

Gianotti, L. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.167 · Cited by 209 · see citing works

Intestinal Microbes in Inflammatory Bowel Diseases

Sartor, R. B., & Mazmanian, S. K. (2012) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2012.4 · Cited by 206 · see citing works

Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in inflammatory bowel disease

Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02754 · Cited by 204 · see citing works

Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works

Siderophore-mediated iron acquisition and modulation of host-bacterial interactions

Ellermann, M., & Arthur, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.489 · Cited by 186 · see citing works

Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases

Koo, H. L., & DuPont, H. L. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328333dc8d · Cited by 189 · see citing works

Do NSAIDs, Antibiotics, Infections, or Stress Trigger Flares in IBD?

Singh, S., Graff, L. A., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.15 · Cited by 181 · see citing works

Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease

Margolis, D. J., Fanelli, M., Hoffstad, O., & Lewis, J. D. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.303 · Cited by 177 · see citing works

Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation

Maharshak, N., Packey, C. D., Ellermann, M., Manick, S., Siddle, J. P., Huh, E. Y., Plevy, S., Sartor, R. B., & Carroll, I. M. (2013) · Gut Microbes · doi:10.4161/gmic.25486 · Cited by 174 · see citing works

Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome

Borton, M. A., Sabag-Daigle, A., Wu, J., Solden, L. M., O’Banion, B. S., Daly, R. A., Wolfe, R. A., Gonzalez, J. F., Wysocki, V. H., Ahmer, B. M. M., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0264-8 · Cited by 149 · see citing works

Dietary heme induces gut dysbiosis, aggravates colitis, and potentiates the development of adenomas in mice

Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01809 · Cited by 161 · see citing works

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

Rieder, F., Kessler, S., Sans, M., & Fiocchi, C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00059.2012 · Cited by 135 · see citing works

Regulatory T‐cell heterogeneity and the cancer immune response

Ward‐Hartstonge, K. A., & Kemp, R. A. (2017) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2017.43 · Cited by 122 · see citing works

Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

Motta, J., Magne, L., Descamps, D., Rolland, C., Squarzoni–Dale, C., Rousset, P., Martin, L., Cenac, N., Balloy, V., Huerre, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.050 · Cited by 130 · see citing works

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

Lopetuso, L. R., Deleu, S., Godny, L., Petito, V., Puca, P., Facciotti, F., Sokol, H., Ianiro, G., Masucci, L., Abreu, M., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-329948 · Cited by 129 · see citing works

Mechanisms underlying immune effects of dietary oligosaccharides

Jeurink, P. V., van Esch, B. C., Rijnierse, A., Garssen, J., & Knippels, L. M. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038596 · Cited by 129 · see citing works

TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury

Ey, B., Eyking, A., Gerken, G., Podolsky, D. K., & Cario, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901619200 · Cited by 119 · see citing works

The Bacteriology of Pouchitis: A Molecular Phylogenetic Analysis Using 16S rRNA Gene Cloning and Sequencing

McLaughlin, S. D., Walker, A. W., Churcher, C., Clark, S. K., Tekkis, P. P., Johnson, M. W., Parkhill, J., Ciclitira, P. J., Dougan, G., Nicholls, R. J., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181e3dc8b · Cited by 114 · see citing works

The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder

Młynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., & Rysz, J. (2022) · Nutrients · doi:10.3390/nu14091921 · Cited by 109 · see citing works

Association of the novel serologic anti-glycan antibodies anti-laminarin and anti-chitin with complicated Crohnʼs disease behavior

Rieder, F., Schleder, S., Wolf, A., Dirmeier, A., Strauch, U., Obermeier, F., Lopez, R., Spector, L., Fire, E., Yarden, J., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21046 · Cited by 101 · see citing works

Glycan recognition at the interface of the intestinal immune system: target for immune modulation via dietary components

de Kivit, S., Kraneveld, A. D., Garssen, J., & Willemsen, L. E. M. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.086 · Cited by 94 · see citing works

Alteration of the Gut Microbiome in Inflammatory Bowel Disease

Andoh, A., & Nishida, A. (2023) · Digestion · doi:10.1159/000525925 · Cited by 88 · see citing works

Chronic intestinal inflammation induces stress-response genes in commensal Escherichia coli

Patwa, L. G., Fan, T., Tchaptchet, S., Liu, Y., Lussier, Y. A., Sartor, R. B., & Hansen, J. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.064 · Cited by 85 · see citing works

Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities

Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84 · see citing works

NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79 · see citing works

A High-Fiber Diet May Improve Bowel Function and Health-Related Quality of Life in Patients With Crohn Disease

Brotherton, C. S., Taylor, A. G., Bourguignon, C., & Anderson, J. G. (2014) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000047 · Cited by 78 · see citing works

Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis

Rees, N. P., Shaheen, W., Quince, C., Tselepis, C., Horniblow, R. D., Sharma, N., Beggs, A. D., Iqbal, T. H., & Quraishi, M. N. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104088 · Cited by 73 · see citing works

Regionally Distinct Alterations in the Composition of the Gut Microbiota in Rats with Streptozotocin-Induced Diabetes

Wirth, R., Bódi, N., Maróti, G., Bagyánszki, M., Talapka, P., Fekete, É., Bagi, Z., & Kovács, K. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110440 · Cited by 69 · see citing works

The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation

Bailey, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.006 · Cited by 69 · see citing works

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease

Noth, R., Stüber, E., Häsler, R., Nikolaus, S., Kühbacher, T., Hampe, J., Bewig, B., Schreiber, S., & Arlt, A. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.10.004 · Cited by 68 · see citing works

Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis

Toumi, R., Abdelouhab, K., Rafa, H., Soufli, I., Raissi-Kerboua, D., Djeraba, Z., & Touil-Boukoffa, C. (2013) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2013.790413 · Cited by 68 · see citing works

Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis

Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00774 · Cited by 67 · see citing works

Intestinal commensal microbiota and cytokines regulate Fut2 ⁺ Paneth cells for gut defense

Kamioka, M., Goto, Y., Nakamura, K., Yokoi, Y., Sugimoto, R., Ohira, S., Kurashima, Y., Umemoto, S., Sato, S., Kunisawa, J., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115230119 · Cited by 62 · see citing works

Metagenomic and metabolomic analysis of the toxic effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in mice

Zhang, Y., Zhao, F., Deng, Y., Zhao, Y., & Ren, H. (2015) · Journal of Proteome Research · doi:10.1021/pr5011263 · Cited by 62 · see citing works

Specific changes of gut commensal microbiota and TLRs during indomethacin-induced acute intestinal inflammation in rats

Terán-Ventura, E., Aguilera, M., Vergara, P., & Martínez, V. (2014) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2014.02.001 · Cited by 59 · see citing works

Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis

De Preter, V., Arijs, I., Windey, K., Vanhove, W., Vermeire, S., Schuit, F., Rutgeerts, P., & Verbeke, K. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22949 · Cited by 49 · see citing works

Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa

Pagnini, C., Corleto, V. D., Mangoni, M. L., Pilozzi, E., Torre, M. S., Marchese, R., Carnuccio, A., Giulio, E. D., & Fave, G. D. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31820abf29 · Cited by 43 · see citing works

Diet promotes dysbiosis and colitis in susceptible hosts

Sartor, R. B. (2012) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.157 · Cited by 43 · see citing works

Peptidoglycan Recognition Protein 3 and Nod2 Synergistically Protect Mice from Dextran Sodium Sulfate–Induced Colitis

Jing, X., Zulfiqar, F., Park, S. Y., Núñez, G., Dziarski, R., & Gupta, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301548 · Cited by 37 · see citing works

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

Barnich, N., Denizot, J., & Darfeuille-Michaud, A. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2010.01.004 · Cited by 34 · see citing works

Discontinuous Variation in the Virulence of Bact. aertrycke Mutton

Wilson, G. S. (1928) · Journal of Hygiene · doi:10.1017/s0022172400009621 · Cited by 10 · see citing works

Mutator Natural Escherichia coli Isolates Have an Unusual Virulence Phenotype

Picard, B., Duriez, P., Gouriou, S., Matić, I., Denamur, É., & Taddéi, F. (2001) · Infection and Immunity · doi:10.1128/iai.69.1.9-14.2001 · Cited by 50 · see citing works

Determination of plasma P-selection in patients with ulcerative colitis and their clinical significance

Quan-zhen, Y. (2004) · Chinese Journal of Laboratory Diagnosis

Virulence evolution

Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0013 · Cited by 3 · see citing works

Exposure to pairs of Aeromonas strains enhances virulence in the Caenorhabditis elegans infection model

Mosser, T., Talagrand-Reboul, É., Colston, S. M., Graf, J., Figueras, M. J., Jumas‐Bilak, E., & Lamy, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01218 · Cited by 42 · see citing works