Graves' ophthalmopathy after subtotal thyroidectomy and radioiodine therapy
Abstract
Forty-five patients with Graves' ophthalmopathy were studied prospectively. Twenty-one patients (42 orbits; group 1) were treated surgically by subtotal thyroidectomy and 24 (48 orbits; group 2) received radioiodine therapy. All patients underwent tests of thyroid function, ophthalmological examination, and axial and coronal computed tomography before and 12 months after treatment. Patients in group 1 showed significant improvement in the Feldon score (P < 0·001), in proptosis as estimated by Hertel exophthalmometry (P < 0·001) and in proptosis (P < 0·001), maximum diameter of the medial rectus (P < 0·01), lateral rectus (P < 0·05), superior group (P < 0·05) and inferior rectus (P < 0·001) muscles as estimated by computed tomography. Patients in group 2 showed significant improvement only in the Feldon score (P < 0·05). The ophthalmopathy of Graves' disease improves to a greater extent after subtotal thyroidectomy than after radioiodine therapy.
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Two early nonrandomized studies found no differences between the three GD therapeutic modalities.
“Two early nonrandomized studies found no differences between the three GD therapeutic modalities (541,545).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [545]
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- Authors
- Fernández Śnchez, J. R., Pradas, J. R., Martinez, O. C., Vela, E. T., Jimenez, F. E., Fuentes, I. G., & Thorbeck, R. V.
- Affiliations
- Department of Surgery, University Hospital , Granada,
- Complejo Hospitalario Universitario de Granada (ES)
- Department of Endocrinology, University Hospital , Granada,
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-09-01
- Volume
- 80
- Issue
- 9
- Pages
- 1134-1136
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2044012428
- Cited by
- 40
- References
- 17
- Citations by year
- 2024: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- Graves' ophthalmopathy, subtotal thyroidectomy, radioiodine therapy, proptosis, orbital computed tomography, Hertel exophthalmometry, treatment comparison
- MeSH terms
- Adolescent, Adult, Aged, Female, Graves Disease, Humans, Iodine Radioisotopes, Male, Middle Aged, Oculomotor Muscles, Prospective Studies, Thyroidectomy, Treatment Outcome
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