The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Risk factors for anastomotic failure after total mesorectal excision of rectal cancer
Abstract
Background: Anastomotic leakage is a major complication of rectal cancer surgery. The aim of this study was to investigate risk factors associated with symptomatic anastomotic leakage after total mesorectal excision (TME). Methods: Between 1996 and 1999, patients with operable rectal cancer were randomized to receive short-term radiotherapy followed by TME or to undergo TME alone. Eligible Dutch patients who underwent an anterior resection (924 patients) were studied retrospectively. Results: Symptomatic anastomotic leakage occurred in 107 patients (11·6 per cent). Pelvic drainage and the use of a defunctioning stoma were significantly associated with a lower anastomotic failure rate. A significant correlation between the absence of a stoma and anastomotic dehiscence was observed in both men and women, for both distal and proximal rectal tumours. In patients with anastomotic failure, the presence of pelvic drains and a covering stoma were both related to a lower requirement for surgical reintervention. Conclusion: Placement of one or more pelvic drains after TME may limit the consequences of anastomotic failure. The clinical decision to construct a defunctioning stoma is supported by this study.
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Metadata
- Authors
- Peeters, K. C. M. J., Tollenaar, R. A. E. M., Marijnen, C. A. M., Klein Kranenbarg, E., Steup, W. H., Wiggers, T., Rutten, H. J., & van de Velde, C. J. H.
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-31
- Volume
- 92
- Issue
- 2
- Pages
- 211-216
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2162901477
- Cited by
- 659
- References
- 22
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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