Prognosis of small thyroid cancer in patients with Graves' disease
Abstract
Background: To find the best ways to follow up patients with small thyroid cancer (STC; 1 cm or less in diameter) and concomitant Graves' disease, this study examined whether such patients had the same excellent prognosis as those with STC without Graves' disease. Methods: Between 1970 and 1996, 2199 patients were diagnosed as having STC by pathology after thyroidectomy. Of those, 509 patients (33 males and 476 females, mean age 43·5 years) underwent thyroidectomy for Graves' disease. Control patients with STC without Graves' disease were matched for age, sex, treatment year and tumour size (33 males and 476 females, mean age 44·0 years). Results: Patients with STC and Graves' disease had a longer disease-free survival than those with STC alone (99 and 93 per cent at 20 years' follow-up, respectively; P < 0·001). The Cox's proportional hazard analysis showed that concomitant Graves' disease and age at surgery are more significant factors for predicting disease-free survival than surgical procedures. Conclusion: Patients who undergo thyroidectomy for Graves' disease and are found to have STC have an excellent prognosis and longer disease-free survival than patients with STC alone.
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Disease-free survival at 20 years is reported to be 99% after thyroidectomy for GD in patients with small (≤1 cm) coexisting thyroid cancers.
“Disease-free survival at 20 years is reported to be 99% after thyroidectomy for GD in patients with small (£1 cm) coexisting thyroid cancers (222).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [222]
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
“Disease-free survival at 20 years is reported to be 99% after thyroidectomy for GD in patients with small (£1 cm) coexisting thyroid cancers (222).”
BackgroundBahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098 · see citing works
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898 · see citing works
- Authors
- Kikuchi, S., Noguchi, S., Yamashita, H., Uchino, S., & Kawamoto, H.
- Affiliations
- Self-Defense Forces Hanshin Hospital (JP)
- Noguchi Thyroid Clinic and Hospital Foundation (JP)
- Corresponding author
- Kikuchi, S
- ORCID
- Yamashita, H
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-07
- Volume
- 93
- Issue
- 4
- Pages
- 434-439
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2041624317
- Cited by
- 49
- References
- 26
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- Graves' disease, thyroidectomy, disease-free survival, prognosis, age at surgery
- MeSH terms
- Adolescent, Adult, Aged, Child, Epidemiologic Methods, Female, Graves Disease, Humans, Male, Middle Aged, Prognosis, Thyroid Neoplasms, Thyroidectomy
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