Epidemiology, risk and prognostic factors in mesenteric venous thrombosis
Abstract
Background: Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce. Methods: Patients with MVT were identified through the inpatient and autopsy registry between 2000 and 2006 at Malmö University Hospital. Results: Fifty-one patients had MVT, diagnosed at autopsy in six. The highest incidence (11·3 per 100 000 person-years) was in the age category 70–79 years. Activated protein C resistance was present in 13 of 29 patients tested. D-dimer at admission was raised in all five patients tested. Multidetector row computed tomography (CT) in the portal venous phase was diagnostic in all 20 patients investigated, of whom 19 were managed conservatively. The median length of resected bowel in 12 patients who had surgery was 0·6 (range 0·1–2·2) m. The overall 30-day mortality rate was 20 per cent; intestinal infarction (P = 0·046), treatment on a non-surgical ward (P = 0·001) and CT not done (P = 0·022) were associated with increased mortality. Cancer was independently associated with long-term mortality: hazard ratio 4·03, 95 per cent confidence interval 1·03 to 15·85; P = 0·046. Conclusion: Portal venous phase CT appeared sensitive in diagnosing MVT. As activated protein C resistance was a strong risk factor, lifelong anticoagulation should be considered.
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Risk factors for ischemic bowel disease include diabetes mellitus, hypertension, coronary artery disease, peripheral artery disease, atrial fibrillation, congestive heart failure, recent myocardial infarction, shock, chronic renal failure requiring hemodialysis, severe dehydration, chronic obstructive lung disease, irritable bowel syndrome, sickle cell crisis with microvascular occlusion, rheumato
“Other risk factors include diabetes mellitus, hypertension, coronary artery disease, peripheral artery disease, atrial fibrillation, congestive heart failure, recent myocardial infarction, shock, chronic renal failure requiring hemodialysis, severe dehydration, chronic obstructive lung disease, irritable bowel syndrome, sickle cell crisis with microvascular occlusion, rheumatic autoimmune diseases”
From Ischemic bowel disease in 2021. (2021) · cites this paper as [6]
Table 3 (Discussion; page not provided) lists severe congestive heart failure among conditions associated with mesenteric venous thrombosis. The Discussion also mentions ischaemic heart disease and renal insufficiency, but as prognostic factors for patients with thrombosis, not risk factors for developing ischaemic bowel disease. The paper does not support most of the listed conditions; notably, it lists inflammatory bowel disease, not irritable bowel syndrome. (LLM, conf=0.88)
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- Authors
- Acosta, S., Alhadad, A., Svensson, P., & Ekberg, O.
- Affiliations
- Skåne University Hospital (SE)
- Department of Coagulation Disorders, Malmö University Hospital, Malmö, Sweden
- Department of Radiology, Malmö University Hospital, Malmö, Sweden
- Corresponding author
- Acosta, S
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-21
- Volume
- 95
- Issue
- 10
- Pages
- 1245-1251
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2054008179
- Cited by
- 288
- References
- 15
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 14 · 2023: 18 · 2022: 19 · 2021: 19 · 2020: 22 · 2019: 12 · 2018: 17 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 25 · 2013: 15 · 2012: 15
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- mesenteric vein thrombosis, risk factors, prognostic factors, activated protein C resistance, D-dimer, portal venous phase CT, intestinal infarction, 30-day mortality, cancer, anticoagulation, incidence, bowel resection
- MeSH terms
- Aged, Aged, 80 and over, Female, Fibrin Fibrinogen Degradation Products, Humans, Male, Mesenteric Veins, Prognosis, Retrospective Studies, Risk Factors, Sweden, Tomography, X-Ray Computed, Thrombolytic Therapy, Incidence, Venous Thrombosis
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