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Preparation of imidazolium ionic liquid functionalized paper membrane for selective extraction of caffeic acid and its structural and functional analogues from Taraxaci Herba
Open accessAbstract
In the search for pharmaceutically active compounds from natural products, it is crucial and challenging to develop separation or purification methods that target not only structurally similar compounds but also those with specific pharmaceutical functions. The adsorption‐based method is widely employed in this field and holds potential for this application, given the diverse range of functional monomers that can be chosen based on structural or functional selectivity. In this work, an imidazolium ionic liquid (IL) modified paper membrane was synthesized via microwave reaction. Caffeic acid (CA), with potential interactions with imidazolium IL and a representative component of phenolic acids in Taraxaci Herba, was chosen as a target compound. After optimization of synthesis and extraction parameters, the resulting extraction membrane could be used to quantitatively analyze CA at ng/ml level, and to extract CA's analogues from the sample matrix. Cheminformatics confirmed the presence of structural and functional similarity among these extracted compounds. This study offers a novel approach to preparing a readily synthesized extraction membrane capable of isolating compounds with structural and functional analogies, as well as developing a membrane solid‐phase extraction‐based analytical method for natural products.
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Recent development and applications of poly (ionic liquid)s in microextraction techniques
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Metadata
- Authors
- Han, X., Li, S., Sun, X., Zhang, J., Zhang, X., & Bi, X.
- Affiliations
- Shandong First Medical University (CN)
- School of Pharmaceutical Sciences and Institute of Materia Medica Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong China
- Corresponding author
- Bi, Xiaodong
- Venue
- Biomedical Chromatography
- Publisher
- Wiley
- Published
- 2024-07-04
- Volume
- 38
- Issue
- 9
- Pages
- e5953-e5953
- ISSN
- 0269-3879 (ISSN-L)
- 1099-0801
- OpenAlex
- W4400369606
- Cited by
- 1
- References
- 1
- Citations by year
- 2025: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomedical Chromatography (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (22376126)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Ionic liquids properties and applications
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
- Keywords
- imidazolium ionic liquids, caffeic acid, phenolic acids, functional analogues, microwave-assisted synthesis, natural product separation, cheminformatics, structural similarity
- MeSH terms
- Caffeic Acids, Chromatography, High Pressure Liquid, Imidazoles, Membranes, Artificial, Paper, Plant Extracts, Reproducibility of Results, Ionic Liquids, Solid Phase Extraction, Limit of Detection
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