Clinical features, MRI, and 18F‐FDG‐PET in differential diagnosis of Parkinson disease from multiple system atrophy
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Objective: This study aimed to differentiate the variations in the clinical characteristics, MRI irregularity, and glucose metabolism on 18 F‐FDG‐PET for the differential diagnosis of Parkinson's Disease (PD), MSA with predominant Parkinsonism (MSA‐P), and MSA with predominant cerebellar features (MSA‐C). Methods: Thirty PD patients, 22 MSA‐P patients, and 28 MSA‐C patients received an MRI and 20 PD patients, 11 MSA‐P patients, and 13 MSA‐C patients received 18 F‐FDG‐PET. Results: Firstly, we found that the clinical data presented a tremor at rest, bradykinesia, and postural instability that was predominated in PD (100%), MSA‐P (86.4%), and MSA‐C (53.6%) patients, respectively. Then, we used MRI analyses and found that putamina atrophy and hyperintensive rim (T 2 WI) were characteristic features in MSA‐P and cerebellar atrophy, the “hot cross bun” sign and signal rise in the middle cerebellar peduncle were more obvious in MSA‐C. To further explore the distinctions among the 3 diseases, we also used 18F‐FDG‐PET technology for our examination and found a decrease in glucose metabolism in the parietal area for Parkinson's Disease (PD), in the bilateral putamen for MSA‐P, and in the bilateral cerebellum for MSA‐C. Conclusion: This study identified the distinctive features of the clinic symptoms, MRI irregularity, and glucose metabolism on 18 F‐FDG‐PET, which provided a new basis for the differential diagnosis of Parkinson's Disease (PD), MSA with predominant Parkinsonism (MSA‐P), and MSA with predominant cerebellar features (MSA‐C).
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Patients with MSA showed bilateral hypometabolism in the basal ganglia through PET-CT examination.
“Moreover, patients with MSA showed bilateral hypometabolism in the basal ganglia through positron emission tomography-computed tomography (PET-CT) [63] examination.”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [63]
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- Authors
- Zhao, P., Zhang, B., Gao, S., & Li, X.
- Affiliations
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Corresponding author
- Zhao, Ping
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2020-09-17
- Volume
- 10
- Issue
- 11
- Pages
- e01827-e01827
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC7667335
- OpenAlex
- W3087295059
- Cited by
- 37
- References
- 35
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, multiple system atrophy, differential diagnosis, 18F-FDG PET, glucose metabolism, magnetic resonance imaging, cerebellar atrophy, hot cross bun sign, middle cerebellar peduncle, tremor, bradykinesia, postural instability
- MeSH terms
- Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Parkinson Disease, Multiple System Atrophy, Fluorodeoxyglucose F18
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