The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Improving Treatment Adherence in Youths with Multidrug-Resistant Tuberculosis with Psychosocial Intervention
Open accessAbstract
INTRODUCTION: Multidrug-resistant tuberculosis (MDR-TB) deeply impacts the well-being of adolescents and young adults (AYA), resulting in poor treatment adherence. Identifying psychosocial challenges and preferred interventions is essential to enhance treatment adherence and outcomes in this unique group. METHODS: This was a mixed-method study where participants aged between 15 and 24 years, diagnosed with MDR-TB, were recruited for in-depth interviews and a semi-structured questionnaire. RESULTS: The individual-level psychosocial challenges included mental stress, suicidal ideation, reluctance to continue medication, perceived and experienced stigma, and socio-economic burdens. Health system-related challenges encompassed delayed diagnosis, drug stockouts, and negative experiences with Health Care Providers (HCPs). Among 75 participants, the median age was 20.5 years, with 57% (n = 41) females, 85% (n = 62) single, and a median treatment duration of 8 months at the interview. Seventy-two percent (n = 54) of the participants reported psychological issues such as irritation, loneliness, anxiety, sleep disorder, suicidal ideation, and stigma. Individual-level interventions were preferred by 61% (n = 46) of participants, including social media, deep breathing, and exercise training. CONCLUSIONS: To enhance results in MDR-TB, it is crucial to develop and assess personalized psychosocial interventions with tailored adjustments to tackle the psychosocial obstacles encountered by adolescents and young adults with MDR-TB.
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“A scoping review is particularly timely now because the End TB Strategy [13] and the WHO mhGAP framework [17] have explicitly called for the integration of mental health and psychosocial care into TB programs, while the number of primary trials and qualitative studies in this area has expanded substantially over the past five years [18,19,20,21].”
From Psychosocial Interventions for Improving Treatment Adherence in Tuberculosis Patients: A Scoping Review of Evidence-Based Approaches. (2026) · cites this paper as [18]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“For adolescents and young adults, digital and mobile health components, brief peer-led psychoeducation, and flexible scheduling are particularly aligned with patient preferences and feasible in resource-constrained settings [18].”
From Psychosocial Interventions for Improving Treatment Adherence in Tuberculosis Patients: A Scoping Review of Evidence-Based Approaches. (2026) · cites this paper as [18]
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“Likewise, Dhumal et al. [18] showed that adolescents and young adults with MDR-TB expressed preferences for digital resources, peer counseling, and flexible delivery formats.”
From Psychosocial Interventions for Improving Treatment Adherence in Tuberculosis Patients: A Scoping Review of Evidence-Based Approaches. (2026) · cites this paper as [18]
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Cites
Our future: a Lancet commission on adolescent health and wellbeing
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Sawyer, S. M., Azzopardi, P. S., Wickremarathne, D., & Patton, G. C. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30022-1 · Cited by 3,666
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Seeking Help From the Internet During Adolescence
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Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis
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- American Psychiatric Association, 2013, DSM‐5‐TR Self‐Rated Level 1 Cross‐Cutting Symptom Measure—Adult, Child Age11–17
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Bin Qamar, R. A., Pereira, H., & Alckmin-Carvalho, F. (2026) · Advances in respiratory medicine · doi:10.3390/arm94030032 · Cited by 1
“For adolescents and young adults, digital and mobile health components, brief peer-led psychoeducation, and flexible scheduling are particularly aligned with patient preferences and feasible in resource-constrained settings [18].”
InfluentialHuang, J., Zhu, Q., Li, Z., Xie, K., Deng, J., Ma, Q., Su, H., Lu, T.-T., Lu, X.-F., Hu, Y.-L., et al. (2026) · Infection and Drug Resistance · doi:10.2147/idr.s590929
Putra, O. N., Purnamasari, T., Julaeha, Yunita, E. P., & Hidayatullah, A. Y. N. (2026) · Asian Pacific Journal of Tropical Medicine · doi:10.4103/apjtm.apjtm_204_26
Metadata
- Authors
- Dhumal, G., Nevrekar, N., Gupte, N., Shrisunder, R., Kulkarni, P., Sarpotdar, S., PM, A., Hosmani, A., Lokhande, R., Gupta, A., & Suryavanshi, N.
- Affiliations
- Johns Hopkins University (US)
- Aundh Chest Hospital Pune India
- B. J. Medical College & Sassoon Hospital (IN)
- Corresponding author
- Dhumal, Gauri
- ORCID
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2025-08
- Volume
- 15
- Issue
- 8
- Pages
- e70665-e70665
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC12321948
- OpenAlex
- W4412998198
- Cited by
- 3
- References
- 32
- Citations by year
- 2026: 3
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- United States Agency for International Development
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- multidrug-resistant tuberculosis, adolescents and young adults, medication adherence, psychosocial interventions, stigma, suicidal ideation, psychological stress, social support, drug stock-outs, health professionals' experiences, personalized interventions, social media, exercise training
- MeSH terms
- Psychosocial Intervention, Adolescent, Adult, Female, Humans, Male, Tuberculosis, Multidrug-Resistant, Medication Adherence, Young Adult, Social Stigma, Suicidal Ideation
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- Dhumal, G., Nevrekar, N., Gupte, N., Shrisunder, R., Kulkarni, P., Sarpotdar, S., PM, A., Hosmani, A., Lokhande, R., Gupta, A., & Suryavanshi, N. (2025). Improving Treatment Adherence in Youths with Multidrug-Resistant Tuberculosis with Psychosocial Intervention. Brain and Behavior. https://doi.org/10.1002/brb3.70665
