The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Are 90% of deaths from cancer caused by metastases?
Open accessAbstract
Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused by metastases. Population‐based data from the Cancer Registry of Norway for the years 2005‐2015 was analyzed. We compared all deaths in the Norwegian population where a cancer diagnosis was registered as cause of death. Deaths caused by cancer, with and without metastases, were analyzed, by sex and tumor group. For solid tumors, 66.7% of cancer deaths were registered with metastases as a contributing cause. Proportions varied substantially between tumor groups. Our data support the idea that the majority of deaths from solid tumors are caused by metastases. Thus, a better understanding of the biology of metastases and identification of druggable targets involved in growth at the metastatic site is a promising strategy to reduce cancer mortality.
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The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
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Suicidal death within a year of a cancer diagnosis: A population‐based study
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Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 513
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373
Altered propionate metabolism contributes to tumour progression and aggressiveness
Gomes, A. P., Ilter, D., Low, V., Drapela, S., Schild, T., Mullarky, E., Han, J., Elia, I., Broekaert, D., Rosenzweig, A., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00553-5 · Cited by 104
Singh, D. P., Pathak, R., Chintalaramulu, N., Pandit, A., Kumar, A., Ebenezer, P. J., Kumar, S., Duplooy, A., White, M. E., Jambunathan, N., et al. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00821-4 · Cited by 12
Tang, Y., Zhang, D., Robinson, S., & Zheng, J. (2023) · Advanced Biology · doi:10.1002/adbi.202300070 · Cited by 9
Metadata
- Authors
- Dillekås, H., Rogers, M. S., & Straume, O.
- Venue
- Cancer Medicine
- Publisher
- Wiley
- Published
- 2019-08-08
- Volume
- 8
- Issue
- 12
- Pages
- 5574-5576
- ISSN
- 2045-7634 (ISSN-L)
- OpenAlex
- W2967213355
- Cited by
- 934
- References
- 8
- FWCI
- 34.01
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dillekås, H., Rogers, M. S., & Straume, O. (2019). Are 90% of deaths from cancer caused by metastases? Cancer Medicine. https://doi.org/10.1002/cam4.2474
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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