Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice
Open accessAbstract
Nimustine (ACNU) has antitumor activities in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are hampered by the hypoxic microenvironment. We examined the combined effects of ACNU and HBO in a GFP transgenic nude mice bearing human glioma model. Mice inoculated with human glioma cells SU 3 were randomly divided into the four groups: (A) the control group, (B) the HBOT (HBO therapy) group, (C) the ACNU group, and (D) the HBOT+ACNU group. Tumor size was measured at the indicated time intervals with a caliper; mice were sacrificed 28 days after treatment, and immunohistochemistry staining and western blot analysis were carried out. By the end of the trial, the tumor weights of groups A, B, C, and D were (P < 0.05), 6.03 ± 1.47, 4.13 ± 1.82 (P < 0.05), 2.39 ± 0.25 (P < 0.05), and 1.43 ± 0.38 (P < 0.01), respectively. The expressions of TNF‐α, MMP 9, HIF‐α, VEGF, NF‐κ B, and IL‐1 β were associated with the infiltration of inflammatory cells and the inhibition rate of tumor cells. Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO 2) in tumor tissues and lower expression levels of HIF‐1 α, TNF‐α, IL‐1 β, VEGF, MMP 9, and NF‐κ B.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HBO can promote the efficacy of cytotoxic drugs.
“In addition, HBO can promote the efficacy of cytotoxic drugs.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [214]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228 · see citing works
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works
Lewis, A. M., Varghese, S., Xu, H., & Alexander, H. R. (2006) · Journal of Translational Medicine · doi:10.1186/1479-5876-4-48 · Cited by 442 · see citing works
Hypoxia‐inducible factors in regulation of immune responses in tumour microenvironment
Kumar, V., & Gabrilovich, D. I. (2014) · Immunology · doi:10.1111/imm.12380 · Cited by 329 · see citing works
Hyperbaric oxygen therapy and cancer—a review
Moen, I. N., & Stuhr, L. E. B. (2012) · Targeted Oncology · doi:10.1007/s11523-012-0233-x · Cited by 304 · see citing works
Homing and Function of Human Skin γδ T Cells and NK Cells: Relevance for Tumor Surveillance
Ebert, L. M., Meuter, S., & Moser, B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4331 · Cited by 243 · see citing works
Is interleukin‐1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?
Apte, R. N., & Voronov, E. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00615.x · Cited by 243 · see citing works
The Role of IL-1β in the Early Tumor Cell–Induced Angiogenic Response
Carmi, Y., Dotan, S., Rider, P., Kaplanov, I., White, M. R., Baron, R., Abutbul, S., Huszar, M., Dinarello, C. A., Apte, R. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202769 · Cited by 209 · see citing works
IL‐1β Promotes Malignant Transformation and Tumor Aggressiveness in Oral Cancer
Lee, C., Chang, J. S.-M., Syu, S., Wong, T., Chan, J. Y. W., Tang, Y., Yang, Z., Yang, W., Chen, C., Lu, S., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24816 · Cited by 201 · see citing works
Collingridge, D. R., Piepmeier, J. M., Rockwell, S., & Knisely, J. P. S. (1999) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(99)00121-8 · Cited by 165 · see citing works
Intratumoral oxygen pressure in malignant brain tumor
Kayama, T., Yoshimoto, T., Fujimoto, S., & Sakurai, Y. (1991) · Journal of neurosurgery · doi:10.3171/jns.1991.74.1.0055 · Cited by 116 · see citing works
Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas
Tarassishin, L., Casper, D., & Lee, S. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103432 · Cited by 97 · see citing works
Glioma Stem/Progenitor Cells Contribute to Neovascularization via Transdifferentiation
Dong, J., Zhao, Y., Huang, Q., Fei, X., Diao, Y., Shen, Y., Xiao, H., Zhang, T., Lan, Q., & Gu, X. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9169-7 · Cited by 84 · see citing works
Self-citationStuhr, L. E. B., Raa, A., Øyan, A. M., Kalland, K. H., Sakariassen, P. O., Petersen, K., Bjerkvig, R., & Reed, R. K. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9407-2 · Cited by 76 · see citing works
Targeting tumour angiogenesis with small molecule inhibitors of hypoxia inducible factor
Nordgren, I. K., & Tavassoli, A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15032d · Cited by 76 · see citing works
Petre, P. M., Baciewicz, F. A., Tigan, S., & Spears, J. R. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2003.90 · Cited by 67 · see citing works
Role of IL-1-Mediated Inflammation in Tumor Angiogenesis
Voronov, E., Carmi, Y., & Apte, R. N. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72005-0_28 · Cited by 62 · see citing works
Endothelial cell transdifferentiation of human glioma stem progenitor cells in vitro
Zhao, Y., Dong, J., Huang, Q., Lou, M., Wang, A., & Lan, Q. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.06.006 · Cited by 56 · see citing works
Self-citationWarren, M. A., Shoemaker, S. F., Shealy, D. J., Bshara, W., & Ip, M. M. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0358 · Cited by 53 · see citing works
Takiguchi, N., Saitô, N., Nunomura, M., Kouda, K., Oda, K., FURUYAMA, N., & Nakajima, N. (2000) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800000190 · Cited by 52 · see citing works
Expression of miR-125b in the new, highly invasive glioma stem cell and progenitor cell line SU3
Wan, Y., Fei, X., Wang, Z.-M., Jiang, D., Chen, H., Yang, J., Shi, L., & Huang, Q. (2012) · 癌症：英文版 · doi:10.5732/cjc.011.10336 · Cited by 50 · see citing works
Self-citationGene expression of the invasive phenotype of TNF-α-treated MCF-7 cells
Yin, Y., Chen, X., & Shu, Y. (2009) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2009.04.032 · Cited by 47 · see citing works
Hyperbaric oxygen therapy in China
Yan, L., Liang, T., & Cheng, O. (2015) · Medical Gas Research · doi:10.1186/s13618-015-0024-4 · Cited by 39 · see citing works
Hai-ya, H., Niu, J., & Lü, Y. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4551 · Cited by 29 · see citing works
The effect of hyperbaric oxygen treatment on pulmonary metastasis in the C3H mouse
Shewell, J., & Thompson, S. C. (1980) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(80)90157-7 · Cited by 29 · see citing works
Lyu, M.-A., & Rosenblum, M. G. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0014 · Cited by 25 · see citing works
Hyperbaric oxygen and cancer: more complex than we expected
Wen-wu, L., Sun, X., Hengyi, T., & Kan, L. (2013) · Targeted Oncology · doi:10.1007/s11523-013-0259-8 · Cited by 19 · see citing works
Dong, J., Dai, X., Lu, Z., Fei, X.-F., Chen, H., Zhang, Q., Zhao, Y., Wang, Z.-M., Wang, A., Lan, Q., et al. (2012) · PubMed · Cited by 15 · see citing works
Self-citationEffect of hyperbaric oxygen therapy on a murine squamous cell carcinoma model
Paniello, R. C., Fraley, P. L., & O'Bert, R. (2013) · Head & Neck · doi:10.1002/hed.23528 · Cited by 7 · see citing works
Lu, Z., Lv, K., ZHANG, J.-S., Dai, C., LIU, B., Ma, X., He, L. J., Jia, J., Chen, Y., Dai, X., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2873 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Luo, Z., Tian, H., Liu, L., Chen, Z., Liang, R., Chen, Z., Wu, Z., Ma, A.-Q., Zheng, M., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.25409 · Cited by 119 · see citing works
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
Won, M., Koo, S., Li, H., Sessler, J. L., Lee, J. Y., Sharma, A. K., & Kim, J. S. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202012687 · Cited by 114 · see citing works
Peña‐Villalobos, I., Casanova-Maldonado, I., Lois, P., Prieto, C. P., Pizarro, C., Lattus, J. M., Osorio, G., & Palma, V. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00995 · Cited by 71 · see citing works
Li, C., Gao, Y., Wang, Y., Wang, J., Lin, J., Du, J., Zhou, Z., Liu, X., Yang, S., & Yang, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202210348 · Cited by 46 · see citing works
Hsu, H., Yang, Y., Chang, W., Fang, W.-Y., Huang, S., Chou, S., & Lo, Y. (2022) · Biomolecules · doi:10.3390/biom12050661 · Cited by 41 · see citing works
Yin, T., Yin, J., Ran, H., Ren, Y., Lu, C., Liu, L., Shi, Q., Qiu, Y., Pan, H., & Ma, A.-Q. (2021) · Biomaterials Science · doi:10.1039/d1bm01710a · Cited by 38 · see citing works
Hyperbaric oxygen therapy can ameliorate the EMT phenomenon in keloid tissue
Zhang, M., Liu, S., Guan, E., Liu, H., Dong, X., Yan, H., Zhang, X., Zhao, P., Liu, X., Pan, S., et al. (2018) · Medicine · doi:10.1097/md.0000000000011529 · Cited by 34 · see citing works
Wu, Z., Lo, J.-J., Wu, S., Wang, C., Chen, R., Lee, S., Chai, C., & Huang, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082195 · Cited by 32 · see citing works
Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas
Chelliah, S. S., Paul, E. A. L., Kamarudin, M. N. A., & Parhar, I. S. (2021) · Molecules · doi:10.3390/molecules26041169 · Cited by 32 · see citing works
Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme
Huang, L., Boling, W., & Zhang, J. H. (2018) · Medical Gas Research · doi:10.4103/2045-9912.229600 · Cited by 29 · see citing works
Chen, H., Ma, A.-Q., Yin, T., Chen, Z., Liang, R., Pan, H., Shen, X., Zheng, M., & Cai, L. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c00921 · Cited by 29 · see citing works
Research progress of anti-glioma chemotherapeutic drugs (Review)
Zhou, Y.-S., Wang, W., Chen, N., Wang, L.-C., & Huang, J. (2022) · Oncology Reports · doi:10.3892/or.2022.8312 · Cited by 27 · see citing works
Recent Research on Methods to Improve Tumor Hypoxia Environment
Zhu, X., Du, J., Zhu, D. Y., Ren, S., Chen, K., & Zhu, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5721258 · Cited by 26 · see citing works
Song, C., Fan, B., & Xiao, Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.039 · Cited by 21 · see citing works
Xie, Y., Zeng, X., Wu, X. G., Hu, J., Zhu, Y., & Yang, X. (2018) · Nanomedicine · doi:10.2217/nnm-2017-0395 · Cited by 22 · see citing works
The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis
Vinkel, J., Arenkiel, B., & Hyldegaard, O. (2023) · Biomolecules · doi:10.3390/biom13081228 · Cited by 20 · see citing works
Wei, X., Qi, Y., Jia, N., Zhou, Q., Zhang, S., & Wang, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26864 · Cited by 20 · see citing works
Boosting Nanomedicine Efficacy with Hyperbaric Oxygen Therapy
Wang, X., Li, S., Liu, X., Wu, X. G., Ye, N., Yang, X., & Li, Z. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_4 · Cited by 20 · see citing works
Xie, T., Wang, J.-R., Dai, C., Fu, X., Dong, J., & Huang, Q. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02234-4 · Cited by 19 · see citing works
Self-citationA narrative review of adjuvant therapy for glioma
Xue, T., Ding, J., Li, B., Cao, D., & Chen, G. (2021) · Medical Gas Research · doi:10.4103/2045-9912.318861 · Cited by 19 · see citing works
Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma
Augur, Z. M., Doyle, C. M., Li, M., Mukherjee, P., & Seyfried, T. N. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00091 · Cited by 17 · see citing works
Self-citationZembrzuska, K., Ostrowski, R. P., & Matyja, E. (2019) · Oncology Reports · doi:10.3892/or.2019.7064 · Cited by 17 · see citing works
Balasubramanian, P., DelFavero, J., Nyúl‐Tóth, Á., Tarantini, A., Gulej, R., & Tarantini, S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.678543 · Cited by 17 · see citing works
Hyperbaric Oxygen Therapy as a Complementary Treatment in Glioblastoma—A Scoping Review
Costa, D. A., Sampaio-Alves, M., Netto, E., Fernandez, G., Oliveira, E., Teixeira, A., Daniel, P. M., Bernardo, G. S., & Amaro, C. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.886603 · Cited by 17 · see citing works
Yuen, C.-M., Tsai, H., Tseng, T.-T., Tseng, Y., Lieu, A., Kwan, A., & Chang, A. Y. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100524 · Cited by 15 · see citing works
Role of hyperbaric oxygen in glioma
Wang, W., Ding, J., Sun, Q., Xu, X. M., & Chen, G. (2021) · Medical Gas Research · doi:10.4103/2045-9912.324589 · Cited by 15 · see citing works
da Silva, S. C., Féres, O., Beggiora, P. D. S., Machado, H. R., Menezes-Reis, R., de Araújo, J. E., Brandão, R. A., & Lopes, L. D. S. (2018) · Child s Nervous System · doi:10.1007/s00381-018-3803-0 · Cited by 14 · see citing works
Wang, P., Gong, S., Pan, J., Wang, J., Zou, D., Xiong, S., Zhao, L., Yan, Q., Deng, Y., Wu, N., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00486-0 · Cited by 16 · see citing works
Hajikarimloo, B., Kavousi, S., Jahromi, G. G., Mehmandoost, M., Oraee‐Yazdani, S., & Fahim, F. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.01.161 · Cited by 11 · see citing works
Won, M., Koo, S., Li, H., Sessler, J. L., Lee, J. Y., Sharma, A. K., & Kim, J. S. (2020) · Angewandte Chemie · doi:10.1002/ange.202012687 · Cited by 9 · see citing works
Wang, Y., Long, J., Shao, D., & Song, H. (2018) · Journal of International Medical Research · doi:10.1177/0300060518767796 · Cited by 9 · see citing works
Ranjan, A., Kishore, D., Ashar, H. K., Neel, T., Singh, A., & More, S. (2021) · International Journal of Hyperthermia · doi:10.1080/02656736.2021.1903582 · Cited by 8 · see citing works
Oxygenating the way for enhanced chemophototherapy
Jiang, W., Delahunty, I. M., & Xie, J. (2018) · Theranostics · doi:10.7150/thno.27810 · Cited by 7 · see citing works
Melatonin for gastric cancer treatment: where do we stand?
Rafiyan, M., Tootoonchi, E., Golpour, M., Davoodvandi, A., Reiter, R. J., Asemi, R., Sharifi, M., Manesh, S. M. R., & Asemi, Z. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03451-7 · Cited by 5 · see citing works
Hyperbaric Oxygen‐Facilitated Cancer Treatment: A Minireview
Li, Z.-R., Zhang, X., & Wu, F. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300162 · Cited by 4 · see citing works
Ren, Z., Wang, R., Wang, C., Ren, X., Dongguo, L., Liu, Y., & Yu, Q. (2024) · Current Medical Science · doi:10.1007/s11596-024-2934-7 · Cited by 4 · see citing works
Targeting the molecular mechanisms of glioma stem cell resistance to chemotherapy
Fares, J., Kanojia, D., Cordero, Á., Ulasov, I. V., & Lesniak, M. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821567-8.00014-2 · Cited by 4 · see citing works
Oxygen-releasing manganese clay hybrid complex triggers p53-mediated cancer cell death in hypoxia
Deepa, Mittal, A., Taxak, S., Tandon, V., & Pati, U. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114054 · Cited by 1 · see citing works
Oxygen therapy in cancer treatment: progress & promises
(2018) · International Journal of Biosciences (IJB) · doi:10.12692/ijb/13.1.72-85
Oxygen therapy in cancer treatment: progress & promisesPreprint
Rai, D. (2022) · doi:10.22541/au.165888617.79233708/v1
Anti-Glioma Agents and Hyperbaric Oxygen for Prospective Therapeutic Approaches
Pucko, E. B., Godlewski, J., Kazmierczak, N., & Ostrowski, R. P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198504
- Authors
- Lu, Z., Ma, J., Liu, B., Dai, C., Xie, T., Ma, X., Li, M., Dong, J., Lan, Q., & Huang, Q.
- Affiliations
- Second Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Dong, Jun
- Venue
- Cancer Medicine
- Publisher
- Wiley
- Published
- 2016-10-13
- Volume
- 5
- Issue
- 11
- Pages
- 3147-3155
- ISSN
- 2045-7634 (ISSN-L)
- PMC
- PMC5119970
- OpenAlex
- W2531008215
- Cited by
- 42
- References
- 30
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 12 · 2017: 1
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancer Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81472739, 81572480, 81172400)
- Natural Science Foundation of Jiangsu Province (BK20151214)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- hyperbaric oxygen therapy, ACNU, glioma, combination therapy, tumor hypoxia, HIF-1α, tumor microenvironment, inflammatory cell infiltration, TNF-α, vascular endothelial growth factor, MMP-9, NF-κB, IL-1β, tumor cell proliferation, oxygen partial pressure
- MeSH terms
- Animals, Antineoplastic Agents, Body Weight, Disease Models, Animal, Glioma, Humans, Hyperbaric Oxygenation, Inflammation, Mice, Transgenic, Models, Biological, Tumor Necrosis Factor-alpha, Nimustine, Signal Transduction, Biomarkers, NF-kappa B, Xenograft Model Antitumor Assays, Cell Line, Tumor, Tumor Burden, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
