Cited by 1,102Cannabis and Cannabinoid ResearchForensic Toxicology and Drug AnalysisPharmacogenetics and Drug Metabolism

The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.

Human Cannabinoid Pharmacokinetics

Open access

Huestis, Marilyn A.·2007·Chemistry & Biodiversity

DOI 10.1002/cbdv.200790152PMC PMC2689518

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1002/cbdv.200790152

Cites

173 of 173 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pharmacokinetics and Pharmacodynamics of Cannabinoids
Grotenhermen, F. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342040-00003 · Cited by 1,514
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Wu, Y.-T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300496 · Cited by 1,024
Cannabidiol and (−)Δ 9 -tetrahydrocannabinol are neuroprotective antioxidants
Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8268 · Cited by 850
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
Zajicek, J., Fox, P., Sanders, H., Wright, D., Vickery, J., Nunn, A., & Thompson, A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14738-1 · Cited by 827
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160105897 · Cited by 669
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608
A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
Russo, E. B., & Guy, G. W. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.08.026 · Cited by 608
Constituents of Cannabis sativa L. XVII. A review of the natural constituents
Turner, C. E., Elsohly, M. A., & Boeren, E. G. (1980) · Journal of Natural Products · doi:10.1021/np50008a001 · Cited by 599
Cannabis: pharmacology and toxicology in animals and humans
Adams, I. B., & Martin, B. R. (1996) · Addiction · doi:10.1046/j.1360-0443.1996.911115852.x · Cited by 576
Cannabinoids control spasticity and tremor in a multiple sclerosis model
Baker, D., Pryce, G., Croxford, J., Brown, P., Pertwee, R., Huffman, J. W., & Layward, L. (2000) · Nature · doi:10.1038/35003583 · Cited by 546

Flagged first, then by citations

Show all 173 references

Research works printed but not linked: 26

Agurell S., 1971, Acta Pharm. Suecica, 8, 391
Agurell S., 1986, Pharmacol. Rev., 38, 21
Azorlosa J. L., 1992, J. Pharmacol. Exper. Ther., 261, 114
Perez‐Reyes M., 1990, NIDA Res. Monograph, 99, 42
Harder S., 1997, Int. J. Clin. Pharmacol. Ther., 35, 155
Ohlsson A., 1981, NIDA Res. Monograph, 34, 250
Meier H. J., 1997, Schweiz. Med. Wochenschr., 127, 214
Brenneisen R., 1996, Int. J. Clin. Pharmacol. Ther., 34, 446
Vinciguerra V., 1988, N. Y. State J. Med., 88, 525
McArdle K., 2001, Toxicology, 168, 133
Garrett E. R., 1978, Adv. Biosci., 22, 105
Hunt C. A., 1980, J. Pharmacol. Exper. Ther., 215, 35
Lee C. C., 1985, NIDA Res. Monograph, 60, 110
Martin B. R., 1977, Res. Commun. Chem. Pathol. Pharmacol., 17, 457
Ben‐Zvi Z., 1974, Res. Commun. Chem. Pathol. Pharmacol., 8, 223
Harvey D. J., 1986, Rev. Biochem. Toxicol., 6, 221
Bornheim L. M., 1992, Drug Metab. Dispos., 20, 241
Halldin M. M., 1982, Drug Metab. Dispos., 10, 297
Chiang C. N., 1987, NIDA Res. Monograph
Bloom A. S., 1982, J. Pharmacol. Exper. Ther., 221, 97
Green M. D., 1997, Drug Metab. Dispos., 25, 1389
Mura P., 1999, Acta Clin. Belg., 1, 35
Soares J. R., 1982, NIDA Res. Monograph, 42, 44
Hawks R. L., 1982, NIDA Res. Monograph, 42, 125
Huestis M. A., 1992, Am. Acad. Forensic Sci. Annual Meeting, 190
Balabanova S., 1989, Beitr. Gerichtl. Med., 48, 45

Sorted by citations

Items 101–200 of 1,000

Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives
Lee, S. H., Kim, H. Y., Back, S. Y., & Han, H. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1418854 · Cited by 93
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human
Basit, A., Neradugomma, N. K., Wolford, C. C., Fan, P. W., Murray, B. P., Takahashi, R., Khojasteh, S. C., Smith, B. J., Heyward, S. A., Totah, R. A., et al. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00559 · Cited by 89
Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats
Bruijnzeel, A. W., Qi, X., Guzhva, L., Wall, S. C., Deng, J. V., Gold, M. S., Febo, M., & Setlow, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153327 · Cited by 89
Dark Classics in Chemical Neuroscience: Δ 9 -Tetrahydrocannabinol
Banister, S. D., Arnold, J. C., Connor, M. A., Glass, M., & McGregor, I. S. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00651 · Cited by 89
Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex®): A Review in Multiple Sclerosis-Related Spasticity
Keating, G. M. (2017) · Drugs · doi:10.1007/s40265-017-0720-6 · Cited by 85
Electrochemical Sensing of Cannabinoids in Biofluids: A Noninvasive Tool for Drug Detection
Klimuntowski, M., Alam, M. M., Singh, G., & Howlader, M. M. R. (2020) · ACS Sensors · doi:10.1021/acssensors.9b02390 · Cited by 88
The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress
Atalay, S., Gęgotek, A., & Skrzydlewska, E. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102489 · Cited by 90
Routes of Administration of Cannabis Used for Nonmedical Purposes and Associations With Patterns of Drug Use
Baggio, S., Deline, S., Studer, J., Mohler‐Kuo, M., Daeppen, J., & Gmel, G. E. (2013) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.08.013 · Cited by 85
Medical Marijuana and Driving: a Review
Neavyn, M., Blohm, E., Babu, K. M., & Bird, S. B. (2014) · Journal of Medical Toxicology · doi:10.1007/s13181-014-0393-4 · Cited by 84
A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens
Spencer, S. M., Neuhofer, D., Chioma, V. C., García‐Keller, C., Schwartz, D., Allen, N. P., Scofield, M. D., Ortiz-Ithier, T., & Kalivas, P. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.016 · Cited by 83
HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients
Rizzo, M. D., Crawford, R. B., Henriquez, J. E., Aldhamen, Y. A., Gulick, P. G., Amalfitano, A., & Kaminski, N. E. (2017) · AIDS · doi:10.1097/qad.0000000000001704 · Cited by 82
Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies
Reddy, D. S. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114237 · Cited by 102
An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine
Klawitter, J., Sempio, C., Mörlein, S., Bloois, E. D., Klepacki, J., Henthorn, T. K., Leehey, M. A., Hoffenberg, E. J., Knupp, K. G., Wang, G. S., et al. (2017) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000427 · Cited by 80
The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study
Eisenberg, E., Ogintz, M., & Almog, S. (2014) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2014.941130 · Cited by 79
Consumers' Perceptions of Edible Marijuana Products for Recreational Use: Likes, Dislikes, and Reasons for Use
Giombi, K., Kosa, K., Rains, C. B., & Cates, S. C. (2017) · Substance Use & Misuse · doi:10.1080/10826084.2017.1343353 · Cited by 79
Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids
Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04592 · Cited by 78
Acute Cannabis Toxicity
Wong, K. U., & Baum, C. R. (2019) · Pediatric Emergency Care · doi:10.1097/pec.0000000000001970 · Cited by 77
Herbal Preparations of Medical Cannabis: A Vademecum for Prescribing Doctors
Brunetti, P., Pichini, S., Pacifici, R., Busardò, F. P., & RIO, A. D. (2020) · Medicina · doi:10.3390/medicina56050237 · Cited by 77
Notes from the Field: Death Following Ingestion of an Edible Marijuana Product ― Colorado, March 2014
Hancock-Allen, J. B., Barker, L. H., VanDyke, M., & Holmes, D. B. (2015) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6428a6 · Cited by 77
Oral Fluid Cannabinoids in Chronic, Daily Cannabis Smokers during Sustained, Monitored Abstinence
Lee, D., Milman, G., Barnes, A. J., Goodwin, R. S., Hirvonen, J., & Huestis, M. A. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.164822 · Cited by 77
Self-citation
Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions
Bell, A. D., MacCallum, C., Margolese, S., Walsh, Z., Wright, P., Daeninck, P. J., Mandarino, E., Lacasse, G., Kaur Deol, J., de Freitas, L., et al. (2024) · Cannabis & Cannabinoid Research · doi:10.1089/can.2021.0156 · Cited by 78
“104,105 A paucity of clinical studies are available regarding the effect of cannabinoids on this enzyme system, but in vitro studies suggest that THC inhibits CYP3A4, CYP3A5, CYP2C9, and CYP2C19, whereas CBD inhibits CYP2C19, CYP3A4, and CYP3A5.”
Background
Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence
Dzierżanowski, T. (2019) · Cancers · doi:10.3390/cancers11020129 · Cited by 79
Cannabinoid interventions for PTSD: Where to next?
Ney, L. J., Matthews, A. J., Bruno, R., & Felmingham, K. L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.017 · Cited by 77
The Effects of Dosage-Controlled Cannabis Capsules on Cancer-Related Cachexia and Anorexia Syndrome in Advanced Cancer Patients: Pilot Study
Bar‐Sela, G., Zalman, D., Semenysty, V., & Ballan, E. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419881498 · Cited by 75
Residual cannabis levels in blood, urine and oral fluid following heavy cannabis use
Odell, M. S., Frei, M. Y., Gerostamoulos, D., Chu, M., & Lubman, D. I. (2015) · Forensic Science International · doi:10.1016/j.forsciint.2015.01.026 · Cited by 75
Cannabinoid exposure during pregnancy and its impact on immune function
Dong, C., Chen, J., Harrington, A., Vinod, K. Y., Hegde, M. L., & Hegde, V. L. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2955-0 · Cited by 77
A Rapid Response Electrochemical Biosensor for Detecting Thc In Saliva
Stevenson, H., Bacon, A., Joseph, K. M., Gwandaru, W. R. W., Bhide, A., Sankhala, D., Dhamu, V. N., & Prasad, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49185-y · Cited by 77
Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood
Bruijnzeel, A. W., Knight, P., Panunzio, S., Xue, S., Bruner, M. M., Wall, S. C., Pompilus, M., Febo, M., & Setlow, B. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05255-7 · Cited by 73
The why behind the high: determinants of neurocognition during acute cannabis exposure
Ramaekers, J. G., Mason, N. L., Kloft, L., & Theunissen, E. L. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00466-4 · Cited by 76
Cannabis and Driving
Pearlson, G. D., Stevens, M. C., & D'Souza, D. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.689444 · Cited by 72
Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-sized bone defects
Kamali, A., Oryan, A., Hosseini, S., Ghanian, M. H., Alizadeh, M., Eslaminejad, M. B., & Baharvand, H. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.03.070 · Cited by 76
Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD)
Hardy, J. R., Greer, R. M., Huggett, G., Kearney, A., Gurgenci, T., & Good, P. D. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.01632 · Cited by 71
Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli
Tan, Z., Clomburg, J. M., & González, R. (2018) · ACS Synthetic Biology · doi:10.1021/acssynbio.8b00075 · Cited by 71
Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids
Reddy, T. S., Zomer, R., & Mantri, N. L. (2023) · Phytotherapy Research · doi:10.1002/ptr.7742 · Cited by 71
Safety Considerations in Cannabinoid-Based Medicine
Gottschling, S., Ayonrinde, O., Bhaskar, A., Blockman, M., D’Agnone, O., Schecter, D., Rodríguez, L. D. S., Yafai, S., & Cyr, C. (2020) · International Journal of General Medicine · doi:10.2147/ijgm.s275049 · Cited by 72
Orodispersible films: Conception to quality by design
Gupta, M. S., Kumar, T. P., Gowda, D. V., & Rosenholm, J. M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113983 · Cited by 69
Medical Cannabis for the Management of Pain and Quality of Life in Chronic Pain Patients: A Prospective Observational Study
Safakish, R., Ko, G. D., Salimpour, V., Hendin, B., Sohanpal, I., Loheswaran, G., & Yoon, S. Y. (2020) · Pain Medicine · doi:10.1093/pm/pnaa163 · Cited by 73
Distribution of free and conjugated cannabinoids in human bile samples
Fabritius, M. M., Staub, C., Mangin, P. J., & Giroud, C. (2012) · Forensic Science International · doi:10.1016/j.forsciint.2012.08.013 · Cited by 67
Do Toxic Synthetic Cannabinoid Receptor Agonists Have Signature in Vitro Activity Profiles? A Case Study of AMB-FUBINACA
Finlay, D. B., Manning, J. J., Ibsen, M. S., Macdonald, C. E., Patel, M., Javitch, J. A., Banister, S. D., & Glass, M. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00429 · Cited by 67
Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers
Moss, M. J., Bushlin, I., Kazmierczak, S. C., Koop, D. R., Hendrickson, R. G., Zuckerman, K. E., & Grigsby, T. M. (2021) · Pediatric Research · doi:10.1038/s41390-020-01332-2 · Cited by 67
Single‐Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology
Atsmon, J., Heffetz, D., Deutsch, L., Deutsch, F., & Sacks, H. (2017) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.408 · Cited by 69
Cannabinoids: Extraction Methods, Analysis, and Physicochemical Characterization
Ramírez, C. L., Fanovich, M. A., & Churio, M. S. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64183-0.00004-x · Cited by 67
Development of a simple and sensitive HPLC–UV method for the simultaneous determination of cannabidiol and Δ9-tetrahydrocannabinol in rat plasma
Zgair, A., Wong, J. C. M., Sabri, A. H. B., Fischer, P. M., Barrett, D. A., Constantinescu, C. S., & Gershkovich, P. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.05.019 · Cited by 70
Cannabidiol (CBD) product contamination: Quantitative analysis of Δ9-tetrahydrocannabinol (Δ9-THC) concentrations found in commercially available CBD products
Johnson, E., Kilgore, M. W., & Babalonis, S. L. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109522 · Cited by 66
Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue
Child, R. B., & Tallon, M. J. (2022) · Nutrients · doi:10.3390/nu14102101 · Cited by 70
The effects of cannabis, cannabinoids, and their administration routes on pain control efficacy and safety: A systematic review and network meta-analysis
Rabgay, K., Waranuch, N., Chaiyakunapruk, N., Sawangjit, R., Ingkaninan, K., & Dilokthornsakul, P. (2019) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2019.07.015 · Cited by 69
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein
Huang, H., McIntosh, A. L., Martin, G. G., Landrock, D., Chung, S., Landrock, K. K., Dangott, L. J., Li, S., Kier, A. B., & Schroeder, F. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00446 · Cited by 64
Medicinal Cannabis Prescribing in Australia: An Analysis of Trends Over the First Five Years
Macphail, S. L., Bedoya‐Pérez, M. A., Cohen, R., Kotsirilos, V., McGregor, I. S., & Cairns, E. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.885655 · Cited by 65
Cannabinoids concentration variability in cannabis olive oil galenic preparations
Carcieri, C., Tomasello, C., Simiele, M., Nicolò, A. D., Avataneo, V., Canzoneri, L., Cusato, J., Perri, G. D., & D’Avolio, A. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12845 · Cited by 64
The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study
Mitelpunkt, A., Kramer, U., Hausman‐Kedem, M., Fink, E. Z., Orbach, R., Chernuha, V., Fattal‐Valevski, A., Deutsch, L., Heffetz, D., & Sacks, H. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.07.007 · Cited by 67
The Transdermal Delivery of Therapeutic Cannabinoids
Mahmoudinoodezh, H., Telukutla, S. R., Bhangu, S. K., Bachari, A., Cavalieri, F., & Mantri, N. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020438 · Cited by 63
Acute Effects of Marijuana Smoking on Negative and Positive Affect
Metrik, J., Kahler, C. W., McGeary, J. E., Monti, P. M., & Rohsenow, D. J. (2011) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.25.1.31 · Cited by 67
Motor neuron development in zebrafish is altered by brief (5-hr) exposures to THC (∆9-tetrahydrocannabinol) or CBD (cannabidiol) during gastrulation
Ahmed, K. T., Amin, M. R., Shah, P., & Ali, D. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-28689-z · Cited by 62
A Conversion of oral cannabidiol to delta9-tetrahydrocannabinol seems not to occur in humans
Nahler, G., Grotenhermen, F., Zuardi, A. W., & Crippa, J. A. S. (2017) · Cannabis & Cannabinoid Research · doi:10.1089/can.2017.0009 · Cited by 61
Δ9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7–Stimulated Human Coculture
Rizzo, M. D., Crawford, R. B., Bach, A. P., Sermet, S., Amalfitano, A., & Kaminski, N. E. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.260661 · Cited by 61
Cannabis, Cannabidiol Oils and Tetrahydrocannabinol—What Do Veterinarians Need to Know?
Briyne, N. D., Holmes, D., Sandler, I., Stiles, E., Szymanski, D., Moody, S., Neumann, S., & Anadón, A. (2021) · Animals · doi:10.3390/ani11030892 · Cited by 61
The cannabinoid system and visual processing: A review on experimental findings and clinical presumptions
Schwitzer, T., Schwan, R., Angioï-Duprez, K., Ingster-Moati, I., Lalanne, L., Giersch, A., & Laprévote, V. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.11.002 · Cited by 66
Establishing legal limits for driving under the influence of marijuana
Wong, K. G., Brady, J. E., & Li, G. (2014) · Injury Epidemiology · doi:10.1186/s40621-014-0026-z · Cited by 61
Teen Use of Marijuana Edibles: A Focus Group Study of an Emerging Issue
Friese, B., Slater, M. D., Annechino, R., & Battle, R. S. (2016) · The Journal of Primary Prevention · doi:10.1007/s10935-016-0432-9 · Cited by 61
Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study
Huntsman, R. J., Tang‐Wai, R., Alcorn, J., Vuong, S., Acton, B. V., Corley, S. D., Laprairie, R. B., Lyon, A. W., Meier, S., Mousseau, D. D., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00716 · Cited by 66
Does cannabis affect dopaminergic signaling in the human brain? A systematic review of evidence to date
Sami, M. B., Rabiner, E. A., & Bhattacharyya, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.011 · Cited by 62
A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age
Sexton, M., Cuttler, C., & Mischley, L. K. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0319 · Cited by 69
Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions
Henson, J. D., Vitetta, L., & Hall, S. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01020-z · Cited by 62
Fatty Acid Binding Protein‐1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias
Schroeder, F., McIntosh, A. L., Martin, G. G., Huang, H., Landrock, D., Chung, S., Landrock, K. K., Dangott, L. J., Li, S., Kaczocha, M., et al. (2016) · Lipids · doi:10.1007/s11745-016-4155-8 · Cited by 61
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models
Richter, J. S., Quenardelle, V., Rouyer, O., Raul, J., Beaujeux, R., Gény, B., & Wolff, V. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00622 · Cited by 59
The evolving landscape of cannabis edibles
Blake, A., & Nahtigal, I. G. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.03.009 · Cited by 66
Consumer use and understanding of labelling information on edible marijuana products sold for recreational use in the states of Colorado and Washington
Kosa, K., Giombi, K., Rains, C. B., & Cates, S. C. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.01.006 · Cited by 57
The failings of per se limits to detect cannabis-induced driving impairment: Results from a simulated driving study
Arkell, T. R., Spindle, T. R., Kevin, R. C., Vandrey, R. G., & McGregor, I. S. (2021) · Traffic Injury Prevention · doi:10.1080/15389588.2020.1851685 · Cited by 57
Therapeutic potential of medicinal marijuana: an educational primer for health care professionals
Mouhamed, Y., Vishnyakov, A., Qorri, B., Sambi, M., Frank, S. M. S., Nowierski, C., Lamba, A., Bhatti, U., & Szewczuk, M. R. (2018) · Drug Healthcare and Patient Safety · doi:10.2147/dhps.s158592 · Cited by 59
Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
Assadpour, E., Rezaei, A., Das, S. S., Rao, B. V. K., Singh, S. K., Kharazmi, M. S., Jha, N. K., Jha, S. K., Prieto, M. A., & Jafari, S. M. (2023) · Pharmaceuticals · doi:10.3390/ph16040487 · Cited by 55
The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis
Maayah, Z. H., Takahara, S., Ferdaoussi, M., & Dyck, J. R. B. (2020) · Inflammation Research · doi:10.1007/s00011-020-01341-1 · Cited by 55
Nabiximols in Chronic Neuropathic Pain: A Meta-Analysis of Randomized Placebo-Controlled Trials
Dykukha, I., Malessa, R., Essner, U., & Ueberall, M. A. (2021) · Pain Medicine · doi:10.1093/pm/pnab050 · Cited by 55
Simultaneous Quantification of 17 Cannabinoids by LC–MS-MS in Human Plasma
Sempio, C., Almaraz-Quinones, N., Jackson, M., Zhao, W., Wang, G. S., Liu, Y., Leehey, M. A., Knupp, K. G., Klawitter, J., Christians, U., et al. (2021) · Journal of Analytical Toxicology · doi:10.1093/jat/bkab030 · Cited by 53
Genetic and Genomic Tools forCannabis sativa
Vergara, D., Baker, H., Clancy, K., Keepers, K. G., Mendieta, J. P., Pauli, C. S., Tittes, S. B., White, K. H., & Kane, N. C. (2016) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2016.1267496 · Cited by 58
Medical Cannabis for Older Patients—Treatment Protocol and Initial Results
Abuhasira, R., Ron, A., Sikorin, I., & Novack, V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111819 · Cited by 59
Pharmacokinetics of Cannabis Brownies: A Controlled Examination of Δ9-Tetrahydrocannabinol and Metabolites in Blood and Oral Fluid of Healthy Adult Males and Females
Spindle, T. R., Cone, E. J., Herrmann, E. S., Mitchell, J. M., Flegel, R. R., LoDico, C., Bigelow, G. E., & Vandrey, R. G. (2020) · Journal of Analytical Toxicology · doi:10.1093/jat/bkaa067 · Cited by 53
Analgesic Effects of Cannabinoids for Chronic Non-cancer Pain: a Systematic Review and Meta-Analysis with Meta-Regression
Wong, S. S. C., Chan, W. S., & Cheung, C. W. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09905-y · Cited by 55
Cannabinoids and the eye
Wang, M. T. M., & Danesh-Meyer, H. V. (2020) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.07.002 · Cited by 53
Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites
Nasrin, S., Watson, C. J. W., Bardhi, K., Fort, G., Chen, G., & Lazarus, P. J. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000530 · Cited by 52
Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug
Procaccia, S., Lewitus, G. M., Feder, C. L., Shapira, A., Berman, P., & Meiri, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.894960 · Cited by 52
A systematic review of passive exposure to cannabis
Berthet, A., Cesare, M. D., Favrat, B., Sporkert, F., Augsburger, M. P., Thomas, A., & Giroud, C. (2016) · Forensic Science International · doi:10.1016/j.forsciint.2016.11.017 · Cited by 52
Cannabis sativa (Hemp) Seeds, Δ 9 -Tetrahydrocannabinol, and Potential Overdose
Yang, Y., Lewis, M. M., Bello, A. M., Wasilewski, E., Clarke, H. A., & Kotra, L. P. (2017) · Cannabis and Cannabinoid Research · doi:10.1089/can.2017.0040 · Cited by 52
Development of an ultra-sensitive electrochemical sensor for Δ9-tetrahydrocannabinol (THC) and its metabolites using carbon paper electrodes
Renaud-Young, M. M., Mayall, R. M., Salehi, V., Golȩdzinowski, M., Comeau, F. J. E., MacCallum, J. L., & Birss, V. I. (2019) · Electrochimica Acta · doi:10.1016/j.electacta.2019.02.117 · Cited by 52
Trends in marijuana edible consumption and perceptions of harm in a cohort of young adults
Reboussin, B. A., Wagoner, K. G., Sutfin, E. L., Suerken, C. K., Ross, J. C., Egan, K. L., Walker, S., & Johnson, R. M. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107660 · Cited by 52
Urinary Pharmacokinetic Profile of Cannabinoids Following Administration of Vaporized and Oral Cannabidiol and Vaporized CBD-Dominant Cannabis
Spindle, T. R., Cone, E. J., Kuntz, D. J., Mitchell, J. M., Bigelow, G. E., Flegel, R. R., & Vandrey, R. G. (2019) · Journal of Analytical Toxicology · doi:10.1093/jat/bkz080 · Cited by 52
The nephrologistʼs guide to cannabis and cannabinoids
Rein, J. L. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000590 · Cited by 55
The synthetic cannabinoid 5F-MDMB-PICA: A case series
Kleis, J., Germerott, T., Halter, S., Héroux, V., Roehrich, J., Schwarz, C.-S., & Hess, C. (2020) · Forensic Science International · doi:10.1016/j.forsciint.2020.110410 · Cited by 52
Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings
Kesner, A. J., & Lovinger, D. M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15369 · Cited by 58
Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia
Berger, A. A., Keefe, J., Winnick, A. A., Gilbert, E., Eskander, J. P., Yazdi, C., Kaye, A. D., Viswanath, O., & Urits, I. (2020) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2020.08.010 · Cited by 57
Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2
Arnold, W. R., Weigle, A. T., & Das, A. (2018) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2018.03.016 · Cited by 51
Maternal hair testing for the assessment of fetal exposure to drug of abuse during early pregnancy: Comparison with testing in placental and fetal remains
Romero, M. F., Pichini, S., Joya, J., Pujadas, M., Sánchez, A., Vall, O., García‐Algar, Ó., Maldonado, A. L., de la Torre, R., Rotolo, M. C., et al. (2011) · Forensic Science International · doi:10.1016/j.forsciint.2011.10.022 · Cited by 50
Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study
Patrician, A., Bratinčević, M. V., Mijačika, T., Banić, I., Marendić, M., Sutlović, D., Dujić, Ž., & Ainslie, P. N. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01074-6 · Cited by 51
Extraction Procedures for Hair Forensic Toxicological Analysis: A Mini-Review
Ferreira, C., Paulino, C., & Quintas, A. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00301 · Cited by 49
Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms
Scheyer, A. F., Laviolette, S. R., Pélissier‐Alicot, A., & Manzoni, O. J. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0183 · Cited by 51
Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy
Bardhi, K., Coates, S., Watson, C. J. W., & Lazarus, P. J. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2148655 · Cited by 54
Endocannabinoids Control Platelet Activation and Limit Aggregate Formation under Flow
Angelis, V. D., Koekman, A. C., Weeterings, C., Roest, M., de Groot, P. G., Herczenik, E., & Maas, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108282 · Cited by 52
Marijuana in the Workplace: Guidance for Occupational Health Professionals and Employers
Phillips, J. A., HOLLAND, M. G., Baldwin, D. D., Meuleveld, L. G., Mueller, K. L., Perkison, B., Upfal, M. J., & Dreger, M. (2015) · Workplace Health & Safety · doi:10.1177/2165079915581983 · Cited by 49
The grass isn’t always greener: The effects of cannabis on embryological development
Friedrich, J., Khatib, D., Parsa, K. M., Santopietro, A., & Gallicano, G. I. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0085-6 · Cited by 49
Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression
Bassi, M. S., Gilio, L., Maffei, P., Dolcetti, E., Bruno, A., Buttari, F., Centonze, D., & Iezzi, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00424 · Cited by 51
A Phase 2, Double‐Blind, Placebo‐Controlled Trial to Investigate Potential Drug‐Drug Interactions Between Cannabidiol and Clobazam
VanLandingham, K., Crockett, J. C., Taylor, L., & Morrison, G. (2020) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1634 · Cited by 53

Authors: Huestis, M. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Huestis, Marilyn A.
ORCID: Huestis, Marilyn A.
Venue: Chemistry & Biodiversity
Publisher: Wiley
Published: 2007-08
Volume: 4
Issue: 8
Pages: 1770-1804
ISSN: 1612-1872 (ISSN-L)
1612-1880
DOI: 10.1002/cbdv.200790152
PMC: PMC2689518
OpenAlex: W2169754532
Cited by: 1,102
References: 173
Citations by year: 2026: 79 · 2025: 97 · 2024: 77 · 2023: 114 · 2022: 109 · 2021: 121 · 2020: 132 · 2019: 117 · 2018: 70 · 2017: 56 · 2016: 42 · 2015: 31 · 2014: 14 · 2013: 13 · 2012: 10
FWCI: 0.35
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations: Chemistry & Biodiversity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (Z01DA000413, Z01DA000415, Z01DA000412)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: cannabinoids, pharmacokinetics, human metabolism, drug absorption, distribution, metabolism, excretion
MeSH terms: Cannabinoids, Humans, Sweat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human Cannabinoid Pharmacokinetics

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks