Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects

Zuardi, A. W.; Shirakawa, I.; Finkelfarb, E.; Karniol, I. G.

doi:10.1007/bf00432554

Cited by 608Cannabis and Cannabinoid ResearchPsychedelics and Drug StudiesMedicinal Plant Extracts Effects

Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects

Zuardi, A. W., Shirakawa, I., Finkelfarb, E., Karniol, I. G.·1982·Psychopharmacology

DOI 10.1007/bf00432554

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Abstract

The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following treatments in a double-blind procedure: 0.5 mg/kg delta 9-THC, 1 mg/kg CBD, a mixture containing 0.5 mg/kg delta 9-THC and 1 mg/kg CBD and placebo and diazepam (10 mg) as controls. Each volunteer received the treatments in a different sequence. It was verified that CBD blocks the anxiety provoked by delta 9-THC, however this effect also extended to marihuana-like effects and to other subjective alterations induced by delta 9-THC. This antagonism does not appear to be caused by a general block of delta 9-THC effects, since no change was detected in the pulse-rate measurements. Several further effects were observed typical of CBD and of an opposite nature to those of delta 9-THC. These results suggest that the effects of CBD, as opposed to those of delta 9-THC, might be involved in the antagonism of effects between the two cannabinoids.

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Oral administration of CBD to healthy volunteers attenuates the anxiogenic effect of Δ9-THC and does not seem to involve pharmacokinetic interactions.
“Oral administration of CBD to healthy volunteers has been shown to attenuate the anxiogenic effect of Δ9-THC and does not seem to involve any pharmacokinetic interactions (Zuardi et al, 1982).”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Zuardi et al, 1982
CBD reverses THC-induced anxiety.
“CBD reverses THC-induced anxiety (Zuardi et al., 1982)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Zuardi et al., 1982
High oral doses of Δ9-THC provoked anxiety and psychotic symptoms in healthy humans, which were attenuated when CBD was administered together with Δ9-THC.
“Studying the interaction between CBD and Δ9-THC in healthy humans, high oral doses of Δ9-THC provoked anxiety and psychotic symptoms, which were attenuated when CBD was administered together with Δ9-THC (15).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [15]

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Authors: Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G.
Affiliations: Universidade Estadual de Campinas (UNICAMP) (BR)
ORCID: Zuardi, A. W.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1982-03
Volume: 76
Issue: 3
Pages: 245-250
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00432554
OpenAlex: W1992318166
Cited by: 608
References: 43
Citations by year: 2026: 14 · 2025: 15 · 2024: 31 · 2023: 35 · 2022: 29 · 2021: 40 · 2020: 40 · 2019: 33 · 2018: 27 · 2017: 35 · 2016: 21 · 2015: 31 · 2014: 16 · 2013: 16 · 2012: 29
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Keywords: cannabidiol, delta-9-tetrahydrocannabinol, cannabis, anxiety, anxiolytic effects, pulse rate, diazepam, subjective effects
MeSH terms: Adult, Anxiety, Cannabidiol, Cannabinoids, Female, Humans, Male, Psychiatric Status Rating Scales, Pulse, Dronabinol

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Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects

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