The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Peptide Nucleic Acids and the Origin of Life
Abstract
The possibilities of pseudo‐peptide‐DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed on the basis of literature data showing that this type of molecules might have formed on the primitive earth (or other places in the universe), as well as data indicating the possibilities of template‐directed PNA chemical replication and ligation. In particular, the merits of an achiral prebiotic genetic material is discussed.
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“This compositionally replicating protocell is equipped to launch a long evolutionary journey, via many hard-to-fathom intermediates, including unorthodox chemistries such as non-canonical amino acids and nucleotide bases as well as unconventional polymers such as polyesters [271] and peptide nucleic acids [272], all the way to the LUCA.”
From Systems protobiology: origin of life in lipid catalytic networks (2018) · cites this paper as [272]
Citations
Cites
A Production of Amino Acids Under Possible Primitive Earth Conditions
Miller, S. L. (1953) · Science · doi:10.1126/science.117.3046.528 · Cited by 3,522
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Self-citationPNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Self-citationThe antiquity of RNA-based evolution.
Joyce, G. F. (2002) · Nature · doi:10.1038/418214a · Cited by 1,070
Mechanism of Synthesis of Adenine from Hydrogen Cyanide under Possible Primitive Earth Conditions
ORÓ, J. (1961) · Nature · doi:10.1038/1911193a0 · Cited by 396
Research works printed but not linked: 17
- 10.1016/0378-1119(93)90046-6 · DOI
- 10.1080/10409230490460765 · DOI · Paper page
- 10.1002/cbdv.200790055 · DOI · Paper page
- 10.1007/BF01582083 · DOI
- 10.1073/pnas.97.8.3868 · DOI · Paper page
- 10.1073/pnas.0403043101 · DOI
- 10.1016/S1074-5521(96)90140-4 · DOI
- 10.1038/376578a0 · DOI
- 10.1073/pnas.84.13.4398 · DOI · Paper page
- 10.1038/nsb0297-98 · DOI
- 10.1038/368561a0 · DOI
- 10.1021/ja00146a001 · DOI
- 10.1002/1521-3773(20001201)39:23<4292::AID-ANIE4292>3.0.CO;2-S · DOI
- 10.1021/ja964341h · DOI
- 10.1021/ja031508f · DOI
- 10.1021/ja0446202 · DOI
- 10.1021/ja0458726 · DOI
Cited by
Sorted by citations
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
The Origin of RNA and “My Grandfather’s Axe”
Hud, N. V., Cafferty, B. J., Krishnamurthy, R., & Williams, L. D. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.03.012 · Cited by 210
Systems protobiology: origin of life in lipid catalytic networks
Lancet, D., Zidovetzki, R., & Markovitch, O. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0159 · Cited by 182
Welcome home, systems chemists
von Kiedrowski, G., Otto, S., & Herdewijn, P. (2010) · Journal of Systems Chemistry · doi:10.1186/1759-2208-1-1 · Cited by 102
Metadata
- Authors
- Nielsen, P. E.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Nielsen, Peter E.
- ORCID
- Nielsen, Peter E.
- Venue
- Chemistry & Biodiversity
- Publisher
- Wiley
- Published
- 2007-09
- Volume
- 4
- Issue
- 9
- Pages
- 1996-2002
- ISSN
- 1612-1872 (ISSN-L)
- 1612-1880
- OpenAlex
- W2066865727
- Cited by
- 75
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemistry & Biodiversity (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- peptide nucleic acid, origin of life, prebiotic chemistry, ligation, early Earth
- MeSH terms
- Origin of Life, Nucleic Acid Conformation, Protein Conformation, Evolution, Molecular, Peptide Nucleic Acids
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