Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

Bataller, R. A., Schwabe, R. F., Choi, Y. H., Yang, L., Paik, Y. H., Lindquist, J. N., Qian, T., Schoonhoven, R., Hagedorn, C. H., Lemasters, J. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18212 · Cited by 566 · see citing works

Antifibrogenic role of the cannabinoid receptor CB2 in the liver

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Apocynin: Molecular Aptitudes

Stefanska, J., & Pawliczak, R. (2008) · Mediators of Inflammation · doi:10.1155/2008/106507 · Cited by 349 · see citing works

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology · doi:10.1002/hep.25938 · Cited by 336 · see citing works

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284 · see citing works

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

Jiang, F., Liu, G., Dusting, G. J., & Chan, E. C. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.012 · Cited by 270 · see citing works

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

Kim, K.-H., Chen, C.-C., Monzon, R. I., & Lau, L. F. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00049-13 · Cited by 261 · see citing works

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

Kim, S. Y., Jeong, J., Kim, S. J., Seo, W., Kim, M., Choi, W., Yoo, W., Lee, J. H., Shim, Y., Yi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02325-2 · Cited by 258 · see citing works

Inflammasome: Its role in traumatic brain and spinal cord injury

Mortezaee, K., Khanlarkhani, N., Beyer, C., & Zendedel, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26287 · Cited by 254 · see citing works

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, J. X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S., & Török, N. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.007 · Cited by 251 · see citing works

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

Csák, T., Velayudham, A., Hritz, I., Petrášek, J., Levin, I., Lippai, D., Catalano, D. E., Mandrekar, P., Dolganiuc, A., Kurt‐Jones, E. A., et al. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00163.2009 · Cited by 229 · see citing works

Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells

Guimarães, E. L. M., Empsen, C., Geerts, A. E., & van Grunsven, L. A. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.007 · Cited by 226 · see citing works

Role of NADPH Oxidases in Liver Fibrosis

Paik, Y., Kim, J., Aoyama, T., Minicis, S. D., Bataller, R. A., & Brenner, D. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5619 · Cited by 221 · see citing works

Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models

Zheng, Z., Zhang, X., Wang, J., Dandekar, A. P., Kim, H., Qiu, Y., Xu, X., Cui, Y., Wang, A., Chen, L., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.020 · Cited by 203 · see citing works

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

Liang, S., Kisseleva, T., & Brenner, D. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00017 · Cited by 197 · see citing works

Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-α production

Thakur, V., Pritchard, M. T., McMullen, M. R., Wang, Q., & Nagy, L. E. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005613 · Cited by 196 · see citing works

The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice

Paik, Y., Iwaisako, K., Seki, E., Inokuchi, S., Schnabl, B., Österreicher, C. H., Kisseleva, T., & Brenner, D. A. (2011) · Hepatology · doi:10.1002/hep.24281 · Cited by 195 · see citing works

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Lan, T., Kisseleva, T., & Brenner, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129743 · Cited by 192 · see citing works

Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

Shi, H., Shi, A., Dong, L., Lu, X., Wang, Y., Zhao, J., Dai, F., & Guo, X. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.002 · Cited by 184 · see citing works

NAD(P)H oxidase plays a crucial role in PDGF‐induced proliferation of hepatic stellate cells

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Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells

Cao, Q., Mak, K. M., Ren, C., & Lieber, C. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308351200 · Cited by 168 · see citing works

Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice

Bettaieb, A., Jiang, J. X., Sasaki, Y., Chao, T.-I., Kiss, Z., Chen, X., Tian, J., Katsuyama, M., Yabe-Nishimura, C., Xi, Y., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.009 · Cited by 167 · see citing works

Regulation of cell proliferation by NADPH oxidase-mediated signaling: Potential roles in tissue repair, regenerative medicine and tissue engineering

Chan, E. C., Jiang, F., Peshavariya, H., & Dusting, G. J. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.005 · Cited by 162 · see citing works

NOX in liver fibrosis

Minicis, S. D., & Brenner, D. A. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.016 · Cited by 161 · see citing works

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

Jiang, J. X., Mikami, K., Venugopal, S. K., Li, Y., & Torok, N. J. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.024 · Cited by 157 · see citing works

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

Sancho, P., Mainez, J., Crosas-Molist, E., Roncero, C., Fernández-Rodríguez, C., Pinedo, F., Huber, H., Eferl, R., Mikulits, W., & Fabregat, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045285 · Cited by 157 · see citing works

Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat

Kono, H., Rusyn, I., Uesugi, T., Yamashina, S., Connor, H. D., Dikalova, A., Mason, R. P., & Thurman, R. G. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g1005 · Cited by 155 · see citing works

Liver Fibrogenesis: A New Role for the Renin–Angiotensin System

Bataller, R. A., Sancho‐Bru, P., Ginès, P., & Brenner, D. A. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1346 · Cited by 154 · see citing works

Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice

Ghatak, S., Biswas, A., Dhali, G. K., Chowdhury, A., Boyer, J. L., & Santra, A. K. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.11.016 · Cited by 150 · see citing works

Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis

Muhanna, N., Doron, S., Wald, O., Horani, A., Eid, A., Pappo, O., Friedman, S. L., & Safadi, R. (2008) · Hepatology · doi:10.1002/hep.22413 · Cited by 147 · see citing works

The nox4 inhibitor gkt137831 attenuates hypoxia-induced pulmonary vascular cell proliferation

Green, D. E., Murphy, T. C., Kang, B.-Y., Kleinhenz, J. M., Szyndralewiez, C., Page, P., Sutliff, R. L., & Hart, C. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0418oc · Cited by 146 · see citing works

Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis

Depner, C. M., Philbrick, K. A., & Jump, D. Β. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171322 · Cited by 145 · see citing works

Signalling via the Osteopontin and High Mobility Group Box-1 Axis Drives the Fibrogenic Response to Liver Injury

Arriazu, E., Ge, X., Leung, T.-M., Magdaleno, F., Lopategi, A., Lu, Y., Kitamura, N., Urtasun, R., Theise, N., Antoine, D. J., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310752 · Cited by 144 · see citing works

Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex

Minicis, S. D., & Brenner, D. A. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05277.x · Cited by 139 · see citing works

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor β-Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

Boudreau, H. E., Emerson, S. U., Korzeniowska, A., Jendrysik, M. A., & Leto, T. L. (2009) · Journal of Virology · doi:10.1128/jvi.01059-09 · Cited by 132 · see citing works

Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells

Novo, E., Busletta, C., di Bonzo, L. V., Povero, D., Paternostro, C., Mareschi, K., Ferrero, I., David, E., Bertolani, C., Caligiuri, A., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.09.022 · Cited by 124 · see citing works

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide

Straub, A. C., Clark, K. A. A., Ross, M. A., Chandra, A. G., Li, S., Gao, X., Pagano, P. J., Stolz, D. B., & Barchowsky, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35092 · Cited by 121 · see citing works

Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice

Menghini, R., Menini, S., Amoruso, R., Fiorentino, L., Casagrande, V., Marzano, V., Tornei, F., Bertucci, P., Iacobini, C., Sérino, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.079 · Cited by 121 · see citing works

NADPH Oxidase in the Liver: Defensive, Offensive, or Fibrogenic?

Minicis, S. D., Bataller, R. A., & Brenner, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.048 · Cited by 121 · see citing works

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

Hou, W., & Syn, W. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00150 · Cited by 121 · see citing works

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo

Jiang, J. X., Venugopal, S. K., Serizawa, N., Chen, X., Scott, F., Li, Y., Adamson, R. H., Devaraj, S., Shah, V. H., Gershwin, M. E., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.074 · Cited by 120 · see citing works

Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

Cao, Z., Ye, T., Sun, Y., Ji, G., Shido, K., Chen, Y., Luo, L., Na, F., Li, X., Huang, Z., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8710 · Cited by 118 · see citing works

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

Colmenero, J., Bataller, R. A., Sancho‐Bru, P., Domínguez, M., Moreno, M., Forns, X., Bruguera, M., Arroyo, V., Brenner, D. A., & Ginès, P. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00162.2009 · Cited by 117 · see citing works

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

Dattaroy, D., Pourhoseini, S., Das, S., Alhasson, F. A., Seth, R. K., Nagarkatti, M., Michelotti, G. A., Diehl, A. M., & Chatterjee, S. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00346.2014 · Cited by 116 · see citing works

High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen‐activated protein kinase

Sugimoto, R., Enjoji, M., Kohjima, M., Tsuruta, S., Fukushima, M., Iwao, M., Sonta, T., Kotoh, K., Inoguchi, T., & Nakamuta, M. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01130.x · Cited by 115 · see citing works

The human Nox4: gene, structure, physiological function and pathological significance

Guo, S., & Chen, X. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1036276 · Cited by 113 · see citing works

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

Cui, W., Matsuno, K., Iwata, K., Ibi, M., Matsumoto, M., Zhang, J., Zhu, K., Katsuyama, M., Torok, N. J., & Yabe‐Nishimura, C. (2011) · Hepatology · doi:10.1002/hep.24465 · Cited by 113 · see citing works

Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats

Tsai, M.-K., Lin, Y., & Huang, Y. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.10.002 · Cited by 111 · see citing works

Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells

Itagaki, T. (2005) · Gut · doi:10.1136/gut.2005.053278 · Cited by 110 · see citing works

NSC23766, a Widely Used Inhibitor of Rac1 Activation, Additionally Acts as a Competitive Antagonist at Muscarinic Acetylcholine Receptors

Levay, M. K., Krobert, K. A., Wittig, K., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.207266 · Cited by 109 · see citing works

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

Katsuyama, M. (2010) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10r01cr · Cited by 104 · see citing works

Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice

Choi, S. S., Sicklick, J. K., Ma, Q., Yang, L., Huang, J., Qi, Y. P., Chen, W., Li, Y.-X., Goldschmidt‐Clermont, P. J., & Diehl, A. M. (2006) · Hepatology · doi:10.1002/hep.21375 · Cited by 104 · see citing works

Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells

Itagaki, T., Shimizu, I., Cheng, X., et al. (2005) · Gut · doi:10.1136/gut.2004.053728 · Cited by 104 · see citing works

Melatonin application in targeting oxidative‐induced liver injuries: A review

Mortezaee, K., & Khanlarkhani, N. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26209 · Cited by 102 · see citing works

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

Dang, D.-K., Shin, E., Nam, Y., Ryoo, S., Jeong, J. H., Jang, C., Nabeshima, T., Hong, J., & Kim, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0478-x · Cited by 94 · see citing works

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

Li, M., Hong, W., Hao, C., Li, L., Wu, D., Shen, A., Lu, J. L., Zheng, Y., Li, P., & Xu, Y. (2017) · The FASEB Journal · doi:10.1096/fj.201700612r · Cited by 91 · see citing works

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

Crosas‐Molist, E., Bertrán, E., Sancho, P., López‐Luque, J., Fernando, J., Sánchez, A., Fernández, M., Navarro, E., & Fabregat, I. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.040 · Cited by 90 · see citing works

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress

Okiyama, W., Tanaka, N., Nakajima, T., Tanaka, E., Kiyosawa, K., Gonzalez, F. J., & Aoyama, T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.025 · Cited by 90 · see citing works

Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells

Minicis, S. D., Seki, E., Oesterreicher, C., Schnabl, B., Schwabe, R. F., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.22560 · Cited by 90 · see citing works

Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma

Choi, J., Corder, N. L. B., Koduru, B., & Wang, Y. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.020 · Cited by 86 · see citing works

Role and Cellular Source of Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Hepatic Fibrosis

Minicis, S. D., Seki, E., Paik, Y., Österreicher, C. H., Kodama, Y., Kluwe, J., Torozzi, L., Miyai, K. N., Benedetti, A., Schwabe, R. F., et al. (2010) · Hepatology · doi:10.1002/hep.23804 · Cited by 83 · see citing works

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

Kostadinova, R., Montagner, A., Gouranton, E., Fleury, S., Guillou, H., Dombrowicz, D., Desreumaux, P., & Wahli, W. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-34 · Cited by 83 · see citing works

Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis

Wang, X., Hausding, M., Weng, S., Kim, Y. O., Steven, S., Klein, T., Daiber, A., & Schuppan, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6953 · Cited by 79 · see citing works

Human hepatocellular carcinoma: Protection by melatonin

Mortezaee, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26586 · Cited by 72 · see citing works

Large hepatitis delta antigen activates STAT‐3 and NF‐κB via oxidative stress

Williams, V., Brichler, S., Khan, E., Chami, M., Dény, P., Kremsdorf, D., & Gordien, E. (2012) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2012.01597.x · Cited by 68 · see citing works

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

Mak, K. Y., Chin, R. A. D., Cunningham, S. C., Habib, M. R., Torresi, J., Sharland, A. F., Alexander, I. E., Angus, P., & Herath, C. B. (2015) · Molecular Therapy · doi:10.1038/mt.2015.92 · Cited by 64 · see citing works

Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor α, reduced glutathione, and transforming growth factor β–dependent mechanisms

Cubero, F. J., & Nieto, N. (2008) · Hepatology · doi:10.1002/hep.22592 · Cited by 59 · see citing works

A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

Zhou, S., Li, W., Shi, F., Zhou, Z.-W., Li, B., Zhang, K., Zhang, X., Ouyang, C., & Zhu, X. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s85426 · Cited by 58 · see citing works

Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis

Zhao, G., Hatting, M., Nevzorova, Y. A., Peng, J., Hu, W., Boekschoten, M. V., Roskams, T., Müller, M. M., Gaßler, N., Liedtke, C., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-305507 · Cited by 58 · see citing works

Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase–dependent mechanism

Jiang, J. X., Mikami, K., Shah, V. H., & Torok, N. J. (2008) · Hepatology · doi:10.1002/hep.22515 · Cited by 54 · see citing works

Melatonin Pretreatment Enhances the Homing of Bone Marrow-derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis.

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Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats

Yang, Z., Wang, H., Zuo, T.-C., et al. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0059-8 · Cited by 52 · see citing works

Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats

Kabirifar, R., Ghoreshi, Z., Safari, F., Karimollah, A., Moradi, A., & Eskandari‐Nasab, E. (2017) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60164-9 · Cited by 52 · see citing works

Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation

Pan, X., Dai, Y., Li, X., Niu, N., Li, W., Liu, F., Zhao, Y., & Yu, Z. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.04.022 · Cited by 51 · see citing works

Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells

Yang, Y. J., Bae, M., Kim, B., Park, Y., Koo, S. I., & Lee, J. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.005 · Cited by 51 · see citing works

Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice

Jiang, J. X., Chen, X., Fukada, H., Serizawa, N., Devaraj, S., & Török, N. J. (2013) · Hepatology · doi:10.1002/hep.26491 · Cited by 49 · cited 1× · see citing works

Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration†

Aram, G., Potter, J. J., Liu, X., Wang, L., Torbenson, M. S., & Mezey, E. (2008) · Hepatology · doi:10.1002/hep.22708 · Cited by 48 · see citing works

Lipid Metabolism, Oxidative Stress and Cell Death Are Regulated by PKC Delta in a Dietary Model of Nonalcoholic Steatohepatitis

Greene, M. W., Burrington, C. M., Lynch, D. T., Davenport, S. K., Johnson, A. K., Horsman, M. J., Chowdhry, S., Zhang, J., Sparks, J. D., & Tirrell, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085848 · Cited by 48 · see citing works

Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice

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Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice

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