Immunomodulatory effects of phytosomal curcumin on related‐micro RNAs, CD200 expression and inflammatory pathways in dental pulp stem cells
Abstract
Human dental pulp stem cells (hDPSCs) have significant potential of immunomodulatory for therapeutic and regenerative biomedical applications compared to other mesenchymal stem cells (MSCs). Nowadays, alteration of gene expression is an important way to improve the performance of MSCs in the clinic. MicroRNAs (miRs) and CD200 are known to modulate the immune system in MSCs. Curcumin is famous for its anti-inflammatory impacts. Phytosomal curcumin (PC) is a nanoparticle synthesized from curcumin that removes the drawbacks of curcumin. The purpose of this research was to assess the effects of PC on the expression of the CD200 and four key miRNAs in immune system. PC (30 μM) treatment of hDPSCs could ameliorate their immunoregulatory property, presented by reduced expressions of miR-21, miR-155 and miR-126, as well as enhanced expressions of miR-23 and CD200. The PC was also able to reduce PI3K\AKT1\NF-κB expressions that were target genes for these miRs and involved in inflammatory pathways. Moreover, PC was more effective than curcumin in improving the immune modulation of hDPSCs. Evidence in this study suggested that PC mediates immunoregulatory activities in hDPSC via miRs and CD200 to regulate PI3K\AKT1\NF-κB signalling pathways, which may provide a theoretical basis for PC in the treatment of many diseases. SIGNIFICANCE OF THE STUDY: Autoimmune diseases or tooth caries are partly attributed to global health problems and their common drug treatments have several side effect…
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miR-23 is upregulated following phytosomal curcumin treatment and is involved in regulating PI3K/AKT1/NF-κB signaling pathways to enhance the immune modulation potential of human dental pulp stem cells.
“Furthermore, miR-23 was found to be upregulated following phytosomal curcumin (PC) treatment and is involved in regulating PI3K/AKT1/NF-κB signaling pathways to enhance the immune modulation potential ability of Human dental pulp stem cells (hDPSCs) [33].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [33]
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- Authors
- Ayadilord, M., Nasseri, S., Emadian Razavi, F., Saharkhiz, M., Rostami, Z., & Naseri, M.
- Affiliations
- Birjand University of Medical Sciences (IR)
- Dental Research Center, Department of Prosthodontics Birjand University of Medical Sciences Birjand Iran
- Corresponding author
- Naseri, Mohsen
- Venue
- Cell Biochemistry and Function
- Publisher
- Wiley
- Published
- 2021-07-07
- Volume
- 39
- Issue
- 7
- Pages
- 886-895
- ISSN
- 0263-6484 (ISSN-L)
- 1099-0844
- OpenAlex
- W3178714776
- Cited by
- 30
- References
- 62
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biochemistry and Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Birjand University of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- dental pulp stem cells, immunomodulation, microRNA, CD200, miR-21, miR-155, miR-126, miR-23, PI3K/Akt signaling, NF-κB signaling, anti-inflammatory activity, dentin regeneration, autoimmune disease, dental caries
- MeSH terms
- Cells, Cultured, Curcumin, Dental Pulp, Humans, Inflammation, Stem Cells, Antigens, CD, MicroRNAs, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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