The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Metallothionein/Thionein System: An Oxidoreductive Metabolic Zinc Link
Abstract
Metallothioneins (MTs) were discovered more than 50 years ago and identified as low‐molecular weight, sulfhydryl‐rich proteins that were subsequently found to bind zinc predominantly. The binding of seemingly redox inactive zinc ions allows MT to play a central role in oxidoreductive cellular metabolism, cellular zinc distribution and homeostasis. In this interpretive study, we discuss the interaction of MT with physiologically relevant molecules and its effect on zincthiolate bonds. These interactions are linked to recent progress in the functional role of MT in cellular zinc transport, energy production, and protection of the organism against oxidative stress and neurodegenerative diseases.
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Cites
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489
Zinc transporters and the cellular trafficking of zinc
Eide, D. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.005 · Cited by 874
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
Gaeta, A., & Hider, R. C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706416 · Cited by 411
Cited by
Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
Etcheverry, P., Grusak, M. A., & Fleige, L. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00317 · Cited by 391
Metallochaperones and metalloregulation in bacteria
Capdevila, D. A., Edmonds, K. A., & Giedroc, D. P. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160076 · Cited by 136
Zinc Piracy as a Mechanism of Neisseria meningitidis for Evasion of Nutritional Immunity
Stork, M., Grijpstra, J., Bos, M. P., Mañas Torres, C., Devos, N., Poolman, J. T., Chazin, W. J., & Tommassen, J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003733 · Cited by 87
Zinc homeostasis and redox alterations in obesity
Franco, C., & Canzoniero, L. M. T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1273177 · Cited by 31
Metadata
- Authors
- Bell, S. G., & Vallee, B. L.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2008-12-29
- Volume
- 10
- Issue
- 1
- Pages
- 55-62
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W1992706834
- Cited by
- 217
- References
- 4
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
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