Zinc transporters and the cellular trafficking of zinc

Eide, David J.

doi:10.1016/j.bbamcr.2006.03.005

Cited by 874Trace Elements in HealthIron Metabolism and DisordersPlant Micronutrient Interactions and Effects

Zinc transporters and the cellular trafficking of zinc

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Eide, David J.·2006·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2006.03.005

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Abstract

Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or structural cofactor for many different proteins. Zinc-dependent proteins are found in the cytoplasm and within many organelles of the eukaryotic cell including the nucleus, the endoplasmic reticulum, Golgi, secretory vesicles, and mitochondria. Thus, cells require zinc transport mechanisms to allow cells to efficiently accumulate the metal ion and distribute it within the cell. Our current knowledge of these transport systems in eukaryotes is the focus of this review.

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The N-terminus of the ZnT family modulates transporter activity by facilitating either protein interactions or zinc binding.
“It has been suggested that the N-terminus of the ZnT family modulates the transporter activity by facilitating either protein interactions or zinc binding [42,43].”
From Human genetic adaptation related to cellular zinc homeostasis (2023) · cites this paper as [42]
Section 2.2 (page not provided) suggests that additional N-terminal domains in Msc2 and ZnT5 may help those proteins interact with their partners. It places the potentially metal-binding histidine-rich motif in a cytoplasmic loop, not the N-terminus. The review therefore supports the proposed interaction role for two family members, but not N-terminal zinc binding or the claim as stated for the ZnT family generally. (LLM, conf=0.85)
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Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter
Wang, F. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh049 · Cited by 159 · see citing works
Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc
Coyle, P. V., Zalewski, P. D., Philcox, J. C., et al. (1994) · Biochemical Journal · doi:10.1042/bj3030781 · Cited by 152 · see citing works
Intracellular free zinc and zinc buffering in human red blood cells
Simons, T. J. B. (1991) · The Journal of Membrane Biology · doi:10.1007/bf01993964 · Cited by 151 · see citing works
An antiport mechanism for a member of the cation diffusion facilitator family: divalent cations efflux in exchange for K+ and H+
Guffanti, A. A., Wei, Y., Rood, S. V., & KRULWICH, T. A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02998.x · Cited by 150 · see citing works
Mutants of Saccharomyces cerevisiae defective in vacuolar function confirm a role for the vacuole in toxic metal ion detoxification
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ZnT-8, A Pancreatic Beta-Cell-Specific Zinc Transporter
Chimienti, F., Favier, A. E., & Sève, M. (2005) · BioMetals · doi:10.1007/s10534-005-3687-9 · Cited by 150 · see citing works
The plant CDF family member TgMTP1 from the Ni/Zn hyperaccumulator Thlaspi goesingense acts to enhance efflux of Zn at the plasma membrane when expressed in Saccharomyces cerevisiae
Kim, D., Gustin, J. L., Lahner, B., Persans, M. W., Baek, D., Yun, D., & Salt, D. E. (2004) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02126.x · Cited by 148 · see citing works
Mouse zinc transporter 1 gene provides an essential function during early embryonic development
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Expression of Zinc Transporter Gene, ZnT-1, Is Induced after Transient Forebrain Ischemia in the Gerbil
Tsuda, M., Imaizumi, K., Katayama, T., Kitagawa, K., Wanaka, A., Tohyama, M., & Takagi, T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06678.1997 · Cited by 140 · see citing works
A new mitochondrial fluorescent zinc sensor
Sensi, S. L., Ton-That, D., Weiss, J. H., Rothe, A., & Gee, K. R. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00122-2 · Cited by 139 · see citing works
Combinatorial Control of Yeast FET4 Gene Expression by Iron, Zinc, and Oxygen
Waters, B. M., & Eide, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206214200 · Cited by 138 · see citing works
Self-citation
Metallothionein Is Part of a Zinc-scavenging Mechanism for Cell Survival under Conditions of Extreme Zinc Deprivation
Suhy, D. A., Simon, K. D., Linzer, D. I. H., & O’Halloran, T. V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9183 · Cited by 134 · see citing works
Zinc-stimulated Endocytosis Controls Activity of the Mouse ZIP1 and ZIP3 Zinc Uptake Transporters
Wang, F., Dufner‐Beattie, J., Kim, B., Petris, M. J., Andrews, G. K., & Eide, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400680200 · Cited by 134 · see citing works
Self-citation
The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex
Nasir, M., Fahrni, C. J., Suhy, D. A., Kolodsick, K. J., Singer, C. P., & O’Halloran, T. V. (1999) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s007750050350 · Cited by 131 · see citing works
Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes
Galperin, M. Y., & Jedrzejas, M. J. (2001) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.1152 · Cited by 126 · see citing works
Intracellular Transport of Proinsulin in Pancreatic β-Cells
Huang, X. F., & Arvan, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20417 · Cited by 123 · see citing works
Copper Chaperones: Personal Escorts for Metal Ions
Field, L. S., Luk, E., & Culotta, V. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1021202119942 · Cited by 123 · see citing works
The Zinc Metalloregulatory Protein Synechococcus PCC7942 SmtB Binds a Single Zinc Ion per Monomer with High Affinity in a Tetrahedral Coordination Geometry
VanZile, M. L., Cosper, N. J., Scott, R. A., & Giedroc, D. P. (2000) · Biochemistry · doi:10.1021/bi001140o · Cited by 120 · see citing works
Heteromeric Protein Complexes Mediate Zinc Transport into the Secretory Pathway of Eukaryotic Cells
Ellis, C. D., MacDiarmid, C. W., & Eide, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505500200 · Cited by 119 · see citing works
Self-citation
Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells
Murgia, C., Vespignani, I., Cerase, J., Nobili, F., & Perozzi, G. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.6.g1231 · Cited by 119 · see citing works
Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function
Bird, A. J., McCall, K., Kramer, M., Blankman, E., Winge, D. R., & Eide, D. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg484 · Cited by 117 · see citing works
Self-citation
Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes
Bloß, T., Clemens, S., & Nies, D. H. (2002) · Planta · doi:10.1007/s00425-001-0677-1 · Cited by 108 · see citing works
ZnT‐1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc
Nolte, C., Gore, A., Sekler, I., Kresse, W., Hershfinkel, M., Hoffmann, A., Kettenmann, H., & Moran, A. (2004) · Glia · doi:10.1002/glia.20065 · Cited by 107 · see citing works
Zn Transporter Levels and Localization Change Throughout Lactation in Rat Mammary Gland and Are Regulated by Zn in Mammary Cells
Kelleher, S. L., & Lönnerdal, B. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3378 · Cited by 102 · see citing works
A Transporter in the Endoplasmic Reticulum of Schizosaccharomyces pombe Cells Mediates Zinc Storage and Differentially Affects Transition Metal Tolerance
Clemens, S., Bloß, T., Vess, C., Neumann, D., Nies, D. H., & Nieden, U. Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201031200 · Cited by 102 · see citing works
The Yeast Gene MSC2, a Member of the Cation Diffusion Facilitator Family, Affects the Cellular Distribution of Zinc
Li, L., & Kaplan, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008969200 · Cited by 99 · see citing works
Retroviral nucleocapsid protein-metal ion interactions: folding and sequence variants.
Green, L. M., & Berg, J. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6403 · Cited by 98 · see citing works
A Reevaluation of Neuronal Zinc Measurements: Artifacts Associated with High Intracellular Dye Concentration
Dineley, K. E., Malaiyandi, L. M., & Reynolds, I. J. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.618 · Cited by 98 · see citing works
Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells
Salazar, G., Craige, B., Love, R., Kalman, D., & Faúndez, V. (2005) · Journal of Cell Science · doi:10.1242/jcs.02319 · Cited by 95 · see citing works
Direct visualization of mitochondrial zinc accumulation reveals uniporter‐dependent and ‐independent transport mechanisms
Malaiyandi, L. M., Vergun, O. V., Dineley, K. E., & Reynolds, I. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03116.x · Cited by 93 · see citing works
A Cytosolic Domain of the Yeast Zrt1 Zinc Transporter Is Required for Its Post-translational Inactivation in Response to Zinc and Cadmium
Gitan, R. S., Shababi, M., Kramer, M. D., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302760200 · Cited by 92 · see citing works
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.
Kang, T., Nagase, H., & Pei, D. (2002) · PubMed · Cited by 90 · see citing works
Fluorescence-based biosensing of zinc using carbonic anhydrase
Fierke, C. A., & Thompson, R. B. (2001) · BioMetals · doi:10.1023/a:1012980628412 · Cited by 87 · see citing works
Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiae
Devirgiliis, C., Murgia, C., Danscher, G., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.051 · Cited by 86 · see citing works
MTP1 mops up excess zinc in Arabidopsis cells
Krämer, U. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.008 · Cited by 86 · see citing works
Intracellular zinc distribution and transport in C6 rat glioma cells
Haase, H., & Beyersmann, D. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02017-x · Cited by 85 · see citing works
Mitochondrial Sequestration and Ca2+-Dependent Release of Cytosolic Zn2+ Loads in Cortical Neurons
Sensi, S. L., Ton-That, D., & Weiss, J. H. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0493 · Cited by 81 · see citing works
Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin
Kelleher, S. L., & Lönnerdal, B. L. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00471.2004 · Cited by 80 · see citing works
Copper Chaperones for Cytochrome c Oxidase and Human Disease
Hamza, I., & Gitlin, J. D. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1021254104012 · Cited by 77 · see citing works
The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2
Bird, A. J., Blankman, E., Stillman, D. J., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600122 · Cited by 77 · see citing works
Generation and Characterization of Mice Lacking the Zinc Uptake Transporter ZIP3
Dufner‐Beattie, J., Huang, Z. L., Geiser, J., Xu, W., & Andrews, G. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5607-5615.2005 · Cited by 76 · see citing works
The Zrc1 Is Involved in Zinc Transport System between Vacuole and Cytosol in Saccharomyces cerevisiae
Miyabe, S., Izawa, S., & Inoue, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4522 · Cited by 75 · see citing works
Is Zn2+ transported by the mitochondrial calcium uniporter?
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Mutation spectrum of humanSLC39A4in a panel of patients with acrodermatitis enteropathica
Küry, S., Kharfi, M., Kamoun, R., Taı̈eb, A., Mallet, E., Baudon, J., Glastre, C., Michel, B., Sebag, F., Brooks, D. G., et al. (2003) · Human Mutation · doi:10.1002/humu.9178 · Cited by 74 · see citing works
Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells
Michalczyk, A. A., Allen, J. M., Blomeley, R. C., & Ackland, M. L. (2002) · Biochemical Journal · doi:10.1042/bj3640105 · Cited by 69 · see citing works
Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae
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Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent probes and atomic absorption
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Oligomeric State of the Escherichia coli Metal Transporter YiiP
Wei, Y., Li, H., & Fu, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407044200 · Cited by 66 · see citing works
Zim17, a Novel Zinc Finger Protein Essential for Protein Import into Mitochondria
Burri, L., Vascotto, K. A., Fredersdorf, S., Tiedt, R., Hall, M. N., & Lithgow, T. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409194200 · Cited by 64 · see citing works
Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria
Costello, L. C., Guan, Z., FRANKLIN, R. B., & Feng, P. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.02.005 · Cited by 60 · see citing works
Ion Transport by Heart Mitochondria. X. The Uptake and Release of Zn2+ and Its Relation to the Energy-Linked Accumulation of Magnesium*
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Differential subcellular localization of hZip1 in adherent and non‐adherent cells
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A decrease in intracellular zinc level precedes the detection of early indicators of apoptosis in HL-60 cells
Duffy, J. Y., Miller, C. M., Rutschilling, G. L., Ridder, G. M., Clegg, M. S., Keen, C. L., & Daston, G. P. (2001) · APOPTOSIS · doi:10.1023/a:1011380508902 · Cited by 42 · see citing works
Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells
Guan, Z., Kukoyi, B., Feng, P., Kennedy, M. C., FRANKLIN, R. B., & Costello, L. C. (2003) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(03)00291-5 · Cited by 42 · see citing works
Zinc Fingers and Thiol−Disulfide Oxidoreductase Activities of Chaperone DnaJ
Tang, W., & Wang, C.-C. (2001) · Biochemistry · doi:10.1021/bi0107593 · Cited by 36 · see citing works
Role of intracellular free Ca(II) and Zn(II) in dexamethasone‐induced apoptosis and dexamethasone resistance in human leukemic CEM cell lines
Adebodun, F., & Post, J. F. M. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041630109 · Cited by 35 · see citing works
Involvement of Intracellular Labile Zinc in Suppression of DEVD-Caspase Activity in Human Neuroblastoma Cells
Ho, L. H., Ratnaike, R. N., & Zalewski, P. D. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2090 · Cited by 34 · see citing works
1,10-Phenanthroline Inhibits Glycosylphosphatidylinositol Anchoring by Preventing Phosphoethanolamine Addition to Glycosylphosphatidylinositol Anchor Precursors
Mann, K. J., & Sevlever, D. (2001) · Biochemistry · doi:10.1021/bi0024512 · Cited by 30 · see citing works
DNA damage-induced [Zn2+]i transients: correlation with cell cycle arrest and apoptosis in lymphoma cells
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Alpha-isopropylmalate synthase from yeast. A zinc metalloenzyme
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A Novel Metalloprotease in Rat Brain Cleaves the Amyloid Precursor Protein of Alzheimer's Disease Generating Amyloidogenic Fragments
Mok, S. S., Evin, G. M., Li, Q., Smith, A. I., Beyreuther, K. T., Masters, C. L., & Small, D. H. (1997) · Biochemistry · doi:10.1021/bi961848w · Cited by 21 · see citing works
The contribution of a zinc finger motif to the function of yeast ribosomal protein YL37a
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Differential Effect of 1,10-Phenanthroline on Mammalian, Yeast, and Parasite Glycosylphosphatidylinositol Anchor Synthesis
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Rapid changes in intracellular Zn2+ in rat hepatocytes
Kleineke, J. W., & Brand, I. A. (1997) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(97)00094-4 · Cited by 17 · see citing works

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Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798 · see citing works
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus
Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6755 · Cited by 654 · see citing works
Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems
Lee, S. R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9156285 · Cited by 458 · see citing works
Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the adaptation to zinc deficiency
Assunção, A. G. L., Herrero, E., Lin, Y.-F., Huettel, B., Talukdar, S., Smaczniak, C., Immink, R. G. H., van Eldik, M., Fiers, M., Schat, H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004788107 · Cited by 379 · see citing works
Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins
Cheng, G., Li, W., Ha, L., Han, X., Hao, S., Wan, Y., Wang, Z., Dong, F., Zou, X., Mao, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03584 · Cited by 371 · see citing works
The Ehlers–Danlos syndromes, rare types
Brady, A. F., Demirdas, S., Fournel‐Gigleux, S., Ghali, N., Giunta, C., Kapferer‐Seebacher, I., Kosho, T., Mendoza‐Londono, R., Pope, M. F., Rohrbach, M., et al. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31550 · Cited by 249 · see citing works
Granulocyte Macrophage-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival
Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, G. S. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.006 · Cited by 230 · see citing works
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells
Aydemir, T. B., Liuzzi, J. P., McClellan, S., & Cousins, R. J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208759 · Cited by 229 · see citing works
Zinc in soil-plant-human system: A data-analysis review
Natasha, N., Shahid, M., Bibi, I., Iqbal, J., Khalid, S., Murtaza, B., Bakhat, H. F., Farooq, A. B. U., Amjad, M., Hammad, H. M., et al. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152024 · Cited by 226 · see citing works
Spondylocheiro Dysplastic Form of the Ehlers-Danlos Syndrome—An Autosomal-Recessive Entity Caused by Mutations in the Zinc Transporter Gene SLC39A13
Giunta, C., Elçioglu, N. H., Albrecht, B., Eich, G., Chambaz, C., Janecke, A. R., Yeowell, H., Weis, M., Eyre, D. R., Kraenzlin, M., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.05.001 · Cited by 218 · see citing works
The Oxidative Stress of Zinc Deficiency
Eide, D. J. (2011) · Metallomics · doi:10.1039/c1mt00064k · Cited by 214 · see citing works
Self-citation
The role of zinc in neurodegenerative inflammatory pathways in depression
Szewczyk, B., Kubera, M., & Nowak, G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.010 · Cited by 176 · see citing works
A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life
Haas, C. E., Rodionov, D. A., Kropat, J., Malasarn, D., Merchant, S. S., & de Crécy-Lagard, V. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-470 · Cited by 159 · see citing works
Candida albicanstranscription factor Rim101 mediates pathogenic interactions through cell wall functions
Nobile, C. J., Solis, N., Myers, C. L., Fay, A. J., Deneault, J.-S., Nantel, A., Mitchell, A. P., & Filler, S. G. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01198.x · Cited by 150 · see citing works
Metal Acquisition and Availability in the Mitochondria
Atkinson, A., & Winge, D. R. (2009) · Chemical Reviews · doi:10.1021/cr900006y · Cited by 146 · see citing works
The Zur-Regulated ZinT Protein Is an Auxiliary Component of the High-Affinity ZnuABC Zinc Transporter That Facilitates Metal Recruitment during Severe Zinc Shortage
Petrarca, P., Ammendola, S., Pasquali, P., & Battistoni, A. (2010) · Journal of Bacteriology · doi:10.1128/jb.01310-09 · Cited by 129 · see citing works
Aspergillus fumigatus Survival in Alkaline and Extreme Zinc-Limiting Environments Relies on the Induction of a Zinc Homeostasis System Encoded by the zrfC and aspf2 Genes
Amich, J., Vicentefranqueira, R., Leal, F., & Calera, J. A. (2010) · Eukaryotic Cell · doi:10.1128/ec.00348-09 · Cited by 105 · see citing works
Bacillithiol is a major buffer of the labile zinc pool in <scp>B</scp>acillus subtilis
Ma, Z., Chandrangsu, P., Helmann, T. C., Romsang, A., Gaballa, A., & Helmann, J. D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12794 · Cited by 96 · see citing works
A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease
Lovell, M. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0992 · Cited by 87 · see citing works
ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation
Inoue, Y., Hasegawa, S., Ban, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S., Tanaka, M., & Hirashima, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.560821 · Cited by 87 · see citing works
Zinc signaling and epilepsy
Doboszewska, U., Młyniec, K., Wlaź, A., Poleszak, E., Nowak, G., & Wlaź, P. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.013 · Cited by 81 · see citing works
Mechanism of HIV Reverse Transcriptase Inhibition by Zinc
Fenstermacher, K. J., & DeStefano, J. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.289850 · Cited by 53 · see citing works
AQUA1 is a mercury sensitive poplar aquaporin regulated at transcriptional and post-translational levels by Zn stress
Ariani, A., Barozzi, F., Sebastiani, L., di Toppi, L. S., di Sansebastiano, G. P., & Andreucci, A. (2019) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2018.10.038 · Cited by 34 · see citing works
Human genetic adaptation related to cellular zinc homeostasis
Roca-Umbert, A., Garcia-Calleja, J., Vogel-González, M., Fierro-Villegas, A., Ill-Raga, G., Herrera-Fernández, V., Bosnjak, A., Muntané, G., Gutiérrez, E., Campelo, F., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010950 · Cited by 8 · see citing works
“It has been suggested that the N-terminus of the ZnT family modulates the transporter activity by facilitating either protein interactions or zinc binding [42,43].”

Unique Golgi apparatus and vesicle formation in a red alga
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The pathway to the cell and its organelles: one hundred years of the Golgi apparatus
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Label-Free Protein Quantification for Plant Golgi Protein Localization and Abundance
Nikolovski, N., Shliaha, P. V., Gatto, L., Dupree, P., & Lilley, K. S. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.245589 · Cited by 50 · see citing works
Facts versus artefacts in cytology: The Golgi apparatus
Bensley, R. R. (1951) · Experimental Cell Research · doi:10.1016/0014-4827(51)90001-8 · Cited by 58 · see citing works
Onco-Golgi: The Missed Target
Sarode, G. S., Sarode, S. C., & Patil, S. (2016) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-1866

Authors: Eide, D. J.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Eide, David J.
ORCID: Eide, David J.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2006-07
Volume: 1763
Issue: 7
Pages: 711-722
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2006.03.005
OpenAlex: W2112310296
Cited by: 874
References: 149
Citations by year: 2026: 26 · 2025: 30 · 2024: 32 · 2023: 33 · 2022: 41 · 2021: 57 · 2020: 57 · 2019: 39 · 2018: 53 · 2017: 55 · 2016: 45 · 2015: 46 · 2014: 57 · 2013: 52 · 2012: 46
FWCI: 4.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2574 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
U.S. Department of Energy
University of Missouri
National Institutes of Health
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords: zinc transporters, zinc homeostasis, metal cofactors, organelles, eukaryotic cells
MeSH terms: Biological Transport, Carrier Proteins, Cell Membrane, Saccharomyces cerevisiae, Zinc, Proteome

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Zinc transporters and the cellular trafficking of zinc

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