The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal–Organic Framework Nanoparticles
Open accessAbstract
Metal–organic frameworks (MOFs) are among the most attractive porous materials available today. They have garnered much attention for their potential utility in many different areas such as gas storage, separation, catalysis, and biomedicine. However, very little is known about the possible health or environmental risks of these materials. Here, the results of toxicity studies on sixteen representative uncoated MOF nanoparticles (nanoMOFs), which were assessed for cytotoxicity to HepG2 and MCF7 cells in vitro, and for toxicity to zebrafish embryos in vivo, are reported. Interestingly, there is a strong correlation between their in vitro toxicity and their in vivo toxicity. NanoMOFs were ranked according to their respective in vivo toxicity (in terms of the amount and severity of phenotypic changes observed in the treated zebrafish embryos), which varied widely. Altogether these results show different levels of toxicity of these materials; however, leaching of solubilized metal ions plays a main role.
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Cites
Brunner, T. J., Wick, P., Manser, P., Spohn, P., Grass, R. N., Limbach, L. K., Bruinink, A., & Stark, W. J. (2006) · Environmental Science & Technology · doi:10.1021/es052069i · Cited by 1,385
Cited by
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Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications
Ettlinger, R., Lächelt, U., Gref, R., Horcajada, P., Lammers, T., Serre, C., Couvreur, P., Morris, R. E., & Wuttke, S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00918d · Cited by 423
Regeneration, degradation, and toxicity effect of MOFs: Opportunities and challenges
Kumar, P., Anand, B., Tsang, Y. F., Kim, K.-H., Khullar, S., & Wang, B. (2019) · Environmental Research · doi:10.1016/j.envres.2019.05.019 · Cited by 319
Metal-Organic Framework (MOF)-Based Drug Delivery
Cao, J., Li, X., & Tian, H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190618152518 · Cited by 282
Metadata
- Authors
- Ruyra, À., Yazdi, A., Espín, J., Carné‐Sánchez, A., Roher, N., Lorenzo, J., Imaz, I., & Maspoch, D.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2014-12-11
- Volume
- 21
- Issue
- 6
- Pages
- 2508-2518
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2084063536
- Cited by
- 299
- References
- 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal–Organic Framework Nanoparticles. https://app.cochat.ai/papers/10.1002/chem.201405380
- The paper
- Ruyra, À., Yazdi, A., Espín, J., Carné‐Sánchez, A., Roher, N., Lorenzo, J., Imaz, I., & Maspoch, D. (2015). Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal–Organic Framework Nanoparticles. Chemistry – A European Journal. https://doi.org/10.1002/chem.201405380
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