Effect of melatonin supplementation on endothelial function in heart failure with reduced ejection fraction: A randomized, double-blinded clinical trial
Open accessAbstract
BACKGROUND: This study aimed to investigate the effect of melatonin supplementation on endothelial function in patients with heart failure with reduced ejection fraction (HFrEF). METHODS: This is an analysis of the MeHR trial, a randomized double-blinded placebo-controlled clinical trial with two parallel arms of 1:1. Oral 10 mg melatonin tablets or placebo was administered for 24 weeks. Deference in the percentage of flow-mediated dilatation (FMD) after the intervention was the primary outcome. RESULTS: Ninety-two patients were included in the study (age: 62.7±10.3 years, 87.0% male, ejection fraction (EF): 28.6±8.1). After adjustment for baseline FMD and age, a statistically significant difference in post-treatment FMD in favor of the melatonin group was seen (estimated marginal means [95%CI], melatonin: 7.84% [6.69-8.98], placebo: 5.98% [4.84-7.12], p = .027). There was no significant difference in the mean of post-treatment systolic/diastolic blood pressure, serum total antioxidant capacity, and serum malondialdehyde (MDA) between groups. Subgroup analysis showed significant improvement in FMD and MDA in the melatonin group in nondiabetic patients, while no difference was seen between study groups in diabetic patients. CONCLUSIONS: Melatonin supplementation in HFrEF might improve endothelial function; however, this beneficial effect might not be seen in diabetic patients.
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Oral 10 mg melatonin daily for twenty-four weeks improved endothelial function in heart failure with reduced ejection fraction patients who did not also have diabetes.
“A randomized double-blinded placebo-controlled clinical trial with two parallel arms using either placebo or oral 10 mg melatonin supplementation per day for twenty-four weeks in patients with heart failure and reduced ejection fraction observed improvements in endothelial function in those who did not also have diabetes [125].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [125]
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“A randomized double-blinded placebo-controlled clinical trial with two parallel arms using either placebo or oral 10 mg melatonin supplementation per day for twentyfour weeks in patients with heart failure and reduced ejection fraction observed improvements in endothelial function in those who did not also have diabet…”
Method
- Authors
- Hoseini, S. G., Heshmat‐Ghahdarijani, K., Khosrawi, S., Garakyaraghi, M., Shafie, D., Roohafza, H., Mansourian, M., Azizi, E., Gheisari, Y., & Sadeghi, M.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Sadeghi, Masoumeh
- ORCID
- Venue
- Clinical Cardiology
- Publisher
- Wiley
- Published
- 2021-06-28
- Volume
- 44
- Issue
- 9
- Pages
- 1263-1271
- ISSN
- 0160-9289 (ISSN-L)
- 1932-8737
- PMC
- PMC8427988
- OpenAlex
- W3173221931
- Cited by
- 22
- References
- 31
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Cardiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute for Medical Research Development (397180)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- melatonin supplementation, endothelial function, heart failure with reduced ejection fraction, flow-mediated dilation, oxidative stress, malondialdehyde, diabetes mellitus, antioxidant capacity
- MeSH terms
- Double-Blind Method, Female, Heart Failure, Humans, Male, Melatonin, Middle Aged, Stroke Volume, Dietary Supplements
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