Disease control and quality of life in chronic spontaneous urticaria and recurrent angioedema are strongly linked, but not in all patients
Open accessAbstract
Background: Patient‐reported outcome measures (PROMs) help to assess disease control and quality of life (QoL) in chronic spontaneous urticaria (CSU) and recurrent angioedema (RA). This study aimed to assess the correlation between two different concepts: disease control and QoL, using disease‐specific PROMs. Methods: We analyzed data from 445 CSU and 330 RA patients who completed both a disease control and QoL PROM as part of the clinical routine. We included the UCT and CU‐Q2oL for CSU and AECT and AE‐QoL for RA. Results: In CSU and RA, disease control scores positively correlated with QoL scores (Spearman's rho correlation coefficient (CR) −0.757, −0.735; p < 0.001) with better disease control corresponding to better quality of life. However, 5.9% of CSU patients and 28% of RA patients with complete disease control had impaired QoL. In CSU, QoL was impaired in 69.2% of patients based on the CU‐Q2oL and in 62.7% of patients based on a single numeric question from the UCT, with a mismatch in 89/445 patients. In RA, QoL was impaired in 58.5% using the AE‐QoL and in 52.7% using a single numeric question from the AECT30mo, with a mismatch in 69/330 patients. Different domains of the QoL PROMs showed different degrees of influence on disease control, with “Itching/Embarrassment” showing the strongest correlation with the UCT (CR −0.804; p < 0.001) and “Functioning” with the AECT3mo (CR −0.824; p < 0.001). Conclusion: Although most patients with controlled disease have better quality of life, unexpectedly, quality of life remains impaired in up to one‐fourth of patients with completely controlled CSU and RA. Reasons behind this should be investigated in further studies.
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Documentation such as a urticaria diary (and possibly photos) can be very helpful in diagnosing and treating chronic urticaria.
“Such documentation, such as a urticaria diary (and possibly photos), can be very helpful in diagnosing and treating the disease [16–20].”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [18]
The Introduction (page unavailable) says patient-reported measures help assess treatment needs and efficacy, which supports a general role for patient documentation in managing chronic urticaria. The Methods > Instruments section describes questionnaires, not a urticaria diary or photos; the paper does not say those forms of documentation help diagnose the disease. (LLM, conf=0.78)
Experimental — accuracy not yet measuredTeledermatology reduces travel burdens and enhances timely medical advice, while chronic urticaria tracking apps improve physician-patient communication.
“Studies show that teledermatology reduces travel burdens and enhances timely medical advice, while CU tracking apps improve physician-patient communication [18–20, 27].”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [18]
The Discussion (page unavailable) says chronic urticaria patients can complete outcome measures through the CRUSE app and that those measures may help guide physicians. It does not say the app improves physician–patient communication, and it does not address teledermatology, travel burdens, or timely medical advice. (LLM, conf=0.80)
Experimental — accuracy not yet measuredMobile health tools such as CRUSE® are feasible and reliable for CU monitoring.
“The CRUSE® study demonstrated their feasibility [18, 19], with Sousa-Pinto et al. [20]. confirming their reliability.”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [18]
The Discussion says digital PROMs can be completed on a phone through the CRUSE app for chronic spontaneous urticaria, supporting the feasibility point. But this paper is a retrospective study of disease control and quality of life, not a CRUSE feasibility study; it cites a separate CRUSE app paper for that example. The citing sentence attributes reliability to Sousa-Pinto et al., not to this source. (LLM, conf=0.85)
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- Authors
- Neisinger, S., Salameh, P., Gutsche, A., Aulenbacher, F., Siebenhaar, F., & Maurer, M.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- University of Nicosia (CY)
- Corresponding author
- Neisinger, Sophia
- ORCID
- Venue
- Clinical and Translational Allergy
- Publisher
- Wiley
- Published
- 2025-01
- Volume
- 15
- Issue
- 1
- Pages
- e70026-e70026
- ISSN
- 2045-7022 (ISSN-L)
- PMC
- PMC11702452
- OpenAlex
- W4406068650
- Cited by
- 8
- References
- 36
- Citations by year
- 2026: 4 · 2025: 4
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical and Translational Allergy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
- Keywords
- chronic spontaneous urticaria, recurrent angioedema, disease control, quality of life, patient-reported outcome measures, UCT, AECT, pruritus, embarrassment, functioning
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