CRUSE ® —An innovative mobile application for patient monitoring and management in chronic spontaneous urticaria
Open accessAbstract
Background: Chronic spontaneous urticaria (CSU) is unpredictable and can severely impair patients' quality of life. Patients with CSU need a convenient, user‐friendly platform to complete patient‐reported outcome measures (PROMs) on their mobile devices. CRUSE ® , the Chronic Urticaria Self Evaluation app, aims to address this unmet need. Methods: CRUSE ® was developed by an international steering committee of urticaria specialists. Priorities for the app based on recent findings in CSU were defined to allow patients to track and record their symptoms and medication use over time and send photographs. The CRUSE ® app collects patient data such as age, sex, disease onset, triggers, medication, and CSU characteristics that can be sent securely to physicians, providing real‐time insights. Additionally, CRUSE ® contains PROMs to assess disease activity and control, which are individualised to patient profiles and clinical manifestations. Results: CRUSE ® was launched in Germany in March 2022 and is now available for free in 17 countries. It is adapted to the local language and displays a country‐specific list of available urticaria medications. English and Ukrainian versions are available worldwide. From July 2022 to June 2023, 25,710 observations were documented by 2540 users; 72.7% were females, with a mean age of 39.6 years. At baseline, 93.7% and 51.3% of users had wheals and angioedema, respectively. Second‐generation antihistamines were used in 74.0% of days. Conclusions: The initial data from CRUSE ® show the wide use and utility of effectively tracking patients' disease activity and control, paving the way for personalised CSU management.
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Teledermatology reduces travel burdens and enhances timely medical advice, while chronic urticaria tracking apps improve physician-patient communication.
“Studies show that teledermatology reduces travel burdens and enhances timely medical advice, while CU tracking apps improve physician-patient communication [18–20, 27].”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [27]
The Introduction says CRUSE lets patients share tracked results with their physicians, and the Discussion describes its potential to improve communication. The paper does not demonstrate that the app improved communication; it presents that benefit as an aim or potential outcome. It does not address the teledermatology travel-burden claim, which the citing sentence also attributes to other references. (LLM, conf=0.84)
Experimental — accuracy not yet measuredTeledermatology reduces travel burdens and enhances timely medical advice, while chronic urticaria tracking apps improve physician-patient communication.
“Studies show that teledermatology reduces travel burdens and enhances timely medical advice, while CU tracking apps improve physician-patient communication [18–20, 27].”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [19]
The Methods section says CRUSE lets patients send symptom scores, medication information and pictures securely to their physicians. The Discussion says this could allow physicians to consider treatment changes in real time, but presents the benefit as potential; it does not demonstrate improved physician–patient communication. The teledermatology claim is not addressed by this source. (LLM, conf=0.84)
Experimental — accuracy not yet measuredDocumentation such as a urticaria diary (and possibly photos) can be very helpful in diagnosing and treating chronic urticaria.
“Such documentation, such as a urticaria diary (and possibly photos), can be very helpful in diagnosing and treating the disease [16–20].”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [19]
The Methods describe recording symptoms and medication use over time, sending photographs, and sharing the records with physicians. The Introduction and Discussion support their use in monitoring disease and informing treatment decisions. The Discussion says further analysis is needed to determine whether the app helps patients receive faster diagnoses, so its diagnostic benefit is not established by this paper. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMobile health tools such as CRUSE® are feasible and reliable for CU monitoring.
“The CRUSE® study demonstrated their feasibility [18, 19], with Sousa-Pinto et al. [20]. confirming their reliability.”
From Acceptance and perceived usefulness of digital health services in the management of chronic urticaria: a survey of patients and physicians (2025) · cites this paper as [19]
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Sousa‐Pinto, B., Ramanauskaite, A., Neisinger, S., Witte‐Händel, E., Gimenez‐Arnau, A. M., Guillet, C., Parisi, C. A. S., Katelaris, C. H., Fomina, D., Larenas‐Linnemann, D., et al. (2025) · Allergy · doi:10.1111/all.16371 · Cited by 11 · see citing works
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“Studies show that teledermatology reduces travel burdens and enhances timely medical advice, while CU tracking apps improve physician-patient communication [18–20, 27 ].”
- Authors
- Neisinger, S., Sousa Pinto, B., Ramanauskaite, A., Bousquet, J., Weller, K., Metz, M., Magerl, M., Kocatürk, E., Cherrez‐Ojeda, I., Gimenez‐Arnau, A. M., Parisi, C. A. S., Altrichter, S., Ensina, L. F., Bouillet, L., Asero, R., Gonçalo, M., Guillet, C., Rutkowski, K., Bernstein, J. A., Hardin, H., Godse, K., Brzoza, Z., Sousa, J. I. L., Thomsen, S. F., van Doorn, M., Hide, M., Ye, Y., Vandersee, S., Lapiņa, L., Peter, J., Zhao, Z., Han, L., Nasr, I., Rockmann‐Helmbach, H., Sørensen, J. A., Kara, R. Ö., Kurjāne, N., Kurchenko, A. I., Kaidashev, I., Tsaryk, V., Stepanenko, R., & Maurer, M.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Faculty of Medicine MEDCIDS‐Department of Community Medicine Information and Health Decision Sciences University of Porto Porto Portugal
- Urticaria Center of Reference and Excellence (UCARE) Institute of Allergology Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Universidade do Porto (PT)
- Koç University (TR)
- Universidad Espíritu Santo Respiralab Research Center Guayaquil Ecuador
- Department of Dermatology UCARE Hospital del Mar and Research Institute Universitat Pompeu Fabra Barcelona Spain
- Hospital Italiano de Buenos Aires (AR)
- Johannes Kepler University of Linz (AT)
- Division of Allergy, Clinical Immunology and Rheumatology Department of Pediatrics Federal University of Sao Paulo Sao Paulo Brazil
- Centre Hospitalier Universitaire de Grenoble (FR)
- Ambulatorio di Allergologia Clinica San Carlo Paderno Dugnano (MI) Italy
- Unidade Local de Saúde de Coimbra (PT)
- University Hospital Zurich (CH)
- Guy's Hospital (GB)
- University of Cincinnati (US)
- Ohio University (US)
- DY Patil Deemed to be University (IN)
- University of Opole (PL)
- Department of Allergy UCARE Clinica San Felipe Lima Peru
- University of Copenhagen (DK)
- Department of Dermatology UCARE Erasmus MC Rotterdam The Netherlands
- Hiroshima City Hiroshima Citizens Hospital (JP)
- Ajou University (KR)
- Charité – Universitätsmedizin Berlin (DE)
- Pauls Stradiņš Clinical University Hospital (LV)
- University of Cape Town (ZA)
- Peking University First Hospital (CN)
- Fudan University (CN)
- Royal Hospital (OM)
- Department of Dermatology/Allergology University Medical Centre Utrecht Utrecht University Utrecht The Netherlands
- Sakarya University (TR)
- Allergic Diseases Diagnosis and Treatment Center Riga Stradins University Pauls Stradins Clinical University Hospital Riga Latvia
- Department of Clinical and Laboratory Immunology, Allergology and Medical Genetics Bogomolets National Medical University Kyiv Ukraine
- Poltava State Medical University Poltava Ukraine
- Bogomolets National Medical University (UA)
- Corresponding author
- Neisinger, Sophia
- ORCID
- Neisinger, Sophia
- Sousa Pinto, Bernardo
- Ramanauskaite, Aiste
- Bousquet, Jean
- Weller, Karsten
- Metz, Martin
- Magerl, Markus
- Kocatürk, Emek
- Cherrez‐Ojeda, Ivan
- Gimenez‐Arnau, Ana M.
- Parisi, Claudio Alberto S.
- Altrichter, Sabine
- Bouillet, Laurence
- Asero, Riccardo
- Gonçalo, Margarida
- Guillet, Carole
- Rutkowski, Krzysztof
- Godse, Kiran
- Brzoza, Zenon
- Thomsen, Simon Francis
- Hide, Michihiro
- Ye, Young‐Min
- Lapiņa, Lāsma
- Peter, Jonny
- Zhao, Zuotao
- Han, Lianyi
- Nasr, Iman
- Sørensen, Jennifer Astrup
- Kara, Rabia Öztaş
- Tsaryk, Vladyslav
- Stepanenko, Roman
- Maurer, Marcus
- Venue
- Clinical and Translational Allergy
- Publisher
- Wiley
- Published
- 2024-01
- Volume
- 14
- Issue
- 1
- Pages
- e12328-e12328
- ISSN
- 2045-7022 (ISSN-L)
- PMC
- PMC10764293
- OpenAlex
- W4390563609
- Cited by
- 37
- References
- 46
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 7
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical and Translational Allergy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- AJOU Open Repository (Ajou University) (submittedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Celldex Therapeutics
- Novartis
- Topics
- Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Keywords
- chronic spontaneous urticaria, mobile health apps, patient-reported outcome measures, disease activity monitoring, symptom monitoring, angioedema, second-generation antihistamines
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