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Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

Bhan, Arunoday, Mandal, Subhrangsu S.·2014·ChemMedChem

DOI 10.1002/cmdc.201300534

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Abstract

Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and transcribed but never get translated into proteins. Though not translated into proteins, ncRNAs play pivotal roles in a variety of cellular functions. Here, we review the functions of long noncoding RNAs (lncRNAs) and their implications in various human diseases. Increasing numbers of studies demonstrate that lncRNAs play critical roles in regulation of protein‐coding genes, maintenance of genomic integrity, dosage compensation, genomic imprinting, mRNA processing, cell differentiation, and development. Misregulation of lncRNAs is associated with a variety of human diseases, including cancer, immune and neurological disorders. Different classes of lncRNAs, their functions, mechanisms of action, and associations with different human diseases are summarized in detail, highlighting their as yet untapped potential in therapy.

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Authors: Bhan, A., & Mandal, S. S.
Venue: ChemMedChem
Publisher: Wiley
Published: 2014-03-26
Volume: 9
Issue: 9
Pages: 1932-1956
ISSN: 1860-7179 (ISSN-L)
1860-7187
DOI: 10.1002/cmdc.201300534
OpenAlex: W2067337865
Cited by: 279
References: 265
FWCI: 6.22
Type: journal article
Language: en
Open access: closed

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Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

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