Cited by 68Cancer-related molecular mechanisms researchRNA Research and SplicingGenetics and Neurodevelopmental Disorders

An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders

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Fenoglio, Chiara, Ridolfi, Elisa, Galimberti, Daniela, Scarpini, Elio·2013·International Journal of Molecular Sciences

Abstract

A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.

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Crossref · 10.3390/ijms141020427

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  • High expression of lncRNAs in the brain is crucial for maintaining neural stem cells, neurogenesis, neural plasticity, and cognitive function.

    “Highly expression of lncRNAs in the brain is crucial for maintaining neural stem cells, neurogenesis, neural plasticity and cognitive function, etc.303”

    From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [303]

    The “Role of lncRNAs in the Central Nervous System” section says lncRNAs affect neural stem cell maintenance, neurogenesis, and neural plasticity, and reports their expression in the brain (page unavailable). It does not establish that high expression is crucial for those processes or for cognitive function. (LLM, conf=0.86)

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Authors
Fenoglio, C., Ridolfi, E., Galimberti, D., & Scarpini, E.
Affiliations
University of Milan (IT)
Corresponding author
Fenoglio, Chiara
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2013-10-14
Volume
14
Issue
10
Pages
20427-20442
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2058341942
Cited by
68
References
94
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6
FWCI
0.41
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
long non-coding RNA, lncRNA dysregulation, neurological disorders, chromatin regulation, dosage compensation, genomic imprinting, stem cell pluripotency, cell fate determination, disease mechanisms
MeSH terms
Animals, Humans, Nervous System Diseases, RNA, Long Noncoding

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