An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders
Open accessAbstract
A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered.
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High expression of lncRNAs in the brain is crucial for maintaining neural stem cells, neurogenesis, neural plasticity, and cognitive function.
“Highly expression of lncRNAs in the brain is crucial for maintaining neural stem cells, neurogenesis, neural plasticity and cognitive function, etc.303”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [303]
The “Role of lncRNAs in the Central Nervous System” section says lncRNAs affect neural stem cell maintenance, neurogenesis, and neural plasticity, and reports their expression in the brain (page unavailable). It does not establish that high expression is crucial for those processes or for cognitive function. (LLM, conf=0.86)
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1 retracted
Bertani, S., Sauer, S., Bolotin, E., & Sauer, F. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.019 · Cited by 220 · see citing works
RetractedLong non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,203 · see citing works
Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181 · see citing works
GENCODE: The reference human genome annotation for The ENCODE Project
Harrow, J., Frankish, A., Gonzalez, J. M., Tapanari, E., Diekhans, M., Kokocinski, F., Aken, B. L., Barrell, D., Zadissa, A., Searle, S., et al. (2012) · Genome Research · doi:10.1101/gr.135350.111 · Cited by 4,585 · see citing works
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246 · see citing works
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098 · see citing works
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1× · see citing works
“Recent studies suggest a potential role for ncRNA in driving chromatin-modifying complexes to genomic loci [11–13],”
BackgroundEpigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232 · see citing works
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927 · see citing works
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872 · see citing works
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086 · see citing works
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
Wang, K., Yang, Y. W., Liu, B., Sanyal, A., Corces, M. R., Chen, Y., Lajoie, B. R., Protacio, A., Flynn, R. A., Gupta, R. A., et al. (2011) · Nature · doi:10.1038/nature09819 · Cited by 1,963 · see citing works
lincRNAs act in the circuitry controlling pluripotency and differentiation
Guttman, M., Donaghey, J., Carey, B. W., Garber, M. G., Grenier, J. K., Munson, G., Young, G., Lucas, A. B., Ach, R. A., Bruhn, L., et al. (2011) · Nature · doi:10.1038/nature10398 · Cited by 1,845 · see citing works
Gutschner, T., & Diederichs, S. (2012) · RNA Biology · doi:10.4161/rna.20481 · Cited by 1,803 · see citing works
Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome
Zhao, J. C., Sun, B. K., Erwin, J. A., Song, J., & Lee, J. T. (2008) · Science · doi:10.1126/science.1163045 · Cited by 1,580 · see citing works
Clemson, C. M., Hutchinson, J. N., Sara, S. A., Ensminger, A. W., Fox, A. H., Chess, A., & Lawrence, J. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.026 · Cited by 1,445 · see citing works
Faghihi, M. A., Modarresi, F., Khalil, A. M., Wood, D. E., Sahagan, B. G., Morgan, T. E., Finch, C. E., St. Laurent III, G., Kenny, P. J., & Wahlestedt, C. (2008) · Nature Medicine · doi:10.1038/nm1784 · Cited by 1,416 · see citing works
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E., & Sasaki, H. (2004) · Nature · doi:10.1038/nature02633 · Cited by 1,392 · see citing works
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254 · see citing works
Kogo, R., Shimamura, T., Mimori, K., Kawahara, K., Imoto, S., Sudo, T., Tanaka, F., Shibata, K., Suzuki, A., Komune, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1021 · Cited by 1,238 · see citing works
Parental imprinting of the mouse H19 gene
Bartolomei, M. S., Zemel, S., & Tilghman, S. M. (1991) · Nature · doi:10.1038/351153a0 · Cited by 1,224 · see citing works
Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., Nagano, T., Mancini‐DiNardo, D., & Kanduri, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.022 · Cited by 1,192 · see citing works
Specific expression of long noncoding RNAs in the mouse brain
Mercer, T. R., Dinger, M. E., Sunkin, S. M., Mehler, M. F., & Mattick, J. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706729105 · Cited by 1,103 · see citing works
The Product of the H19 Gene May Function as an RNA
Brannan, C. I., Dees, E. C., Ingram, R. S., & Tilghman, S. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.28 · Cited by 1,087 · see citing works
Prensner, J. R., Iyer, M. K., Balbin, O. A., Dhanasekaran, S. M., Cao, Q., Brenner, J. C., Laxman, B., Asangani, I. A., Grasso, C. S., Kominsky, H. D., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1914 · Cited by 1,026 · see citing works
An RNA gene expressed during cortical development evolved rapidly in humans
Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M.-A., Coppens, S., Pedersen, J. S., Katzman, S., King, B., Onodera, C., Siepel, A., et al. (2006) · Nature · doi:10.1038/nature05113 · Cited by 1,005 · see citing works
Kotake, Y., Nakagawa, T., Kitagawa, K., Suzuki, S., Liu, N., Kitagawa, M., & Xiong, Y. (2011) · Oncogene · doi:10.1038/onc.2010.568 · Cited by 1,001 · see citing works
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Loewer, S., Cabili, M. N., Guttman, M., Loh, Y., Thomas, K., Park, I. H., Garber, M. G., Curran, M. S., Önder, T. T., Agarwal, S., et al. (2010) · Nature Genetics · doi:10.1038/ng.710 · Cited by 971 · see citing works
The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin
Nagano, T., Mitchell, J. A., Sanz, L. A., Pauler, F. M., Ferguson‐Smith, A. C., Feil, R., & Fraser, P. (2008) · Science · doi:10.1126/science.1163802 · Cited by 907 · see citing works
Modulating Hox gene functions during animal body patterning
Pearson, J. C., Lemons, D., & McGinnis, W. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1726 · Cited by 879 · see citing works
Non‐coding RNAs: the architects of eukaryotic complexity
Mattick, J. S. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve230 · Cited by 848 · see citing works
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r
Keniry, A., Oxley, D., Monnier, P., Kyba, M., Dandolo, L., Smits, G., & Reik, W. (2012) · Nature Cell Biology · doi:10.1038/ncb2521 · Cited by 806 · see citing works
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
Kim, K., Jutooru, I., Chadalapaka, G., Johnson, G. A., Frank, J., Burghardt, R. C., Kim, S., & Safe, S. H. (2012) · Oncogene · doi:10.1038/onc.2012.193 · Cited by 781 · see citing works
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
Bernard, D., Prasanth, K. V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, Z., Zhang, M. Q., Sedel, F., Jourdren, L., Coulpier, F., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.199 · Cited by 738 · see citing works
A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT
Willingham, A. T., Orth, A. P., Batalov, S., Peters, E. C., Wen, B., Aza‐Blanc, P., Hogenesch, J. B., & Schultz, P. G. (2005) · Science · doi:10.1126/science.1115901 · Cited by 731 · see citing works
Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes & Development · doi:10.1101/gad.1416106 · Cited by 712 · see citing works
Yang, Z., Zhou, L., Wu, L., Lai, M.-C., Xie, H., Zhang, F., & Zheng, S. (2011) · Annals of Surgical Oncology · doi:10.1245/s10434-011-1581-y · Cited by 709 · see citing works
The Genetic Signatures of Noncoding RNAs
Mattick, J. S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000459 · Cited by 704 · see citing works
Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction
Ishii, N., Ozaki, K., Sato, H., Mizuno, H., Saito, S., Takahashi, A., Miyamoto, Y., Ikegawa, S., Kamatani, N., Hori, M., et al. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0070-9 · Cited by 652 · see citing works
The imprinted H19 noncoding RNA is a primary microRNA precursor
Cai, X., & Cullen, B. R. (2007) · RNA · doi:10.1261/rna.351707 · Cited by 642 · see citing works
The <i>H19</i> locus: Role of an imprinted non‐coding RNA in growth and development
Gabory, A., Jammes, H., & Dandolo, L. (2010) · BioEssays · doi:10.1002/bies.200900170 · Cited by 568 · see citing works
The DISC locus in psychiatric illness
Chubb, J. E., Bradshaw, N. J., Soares, D. C., Porteous, D. J., & Millar, J. K. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002106 · Cited by 542 · see citing works
Mutations in SOX2 cause anophthalmia
Fantes, J. A., Ragge, N., Lynch, S. A., McGill, N. I., Collin, J. R. O., Howard‐Peebles, P. N., Hayward, C., Vivian, A. J., Williamson, K. A., van Heyningen, V., et al. (2003) · Nature Genetics · doi:10.1038/ng1120 · Cited by 538 · see citing works
The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation
Tian, D., Sun, S., & Lee, J. T. (2010) · Cell · doi:10.1016/j.cell.2010.09.049 · Cited by 516 · see citing works
Broadbent, H. M., Peden, J. F., Stefan Lorkowski, A., Goel, A., Ongen, H., Green, F. R., Clarke, R., Collins, R., Franzosi, M. G., Tognoni, G., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm352 · Cited by 504 · see citing works
The Noncoding RNA Taurine Upregulated Gene 1 Is Required for Differentiation of the Murine Retina
Young‐Pearse, T. L., Matsuda, T., & Cepko, C. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.027 · Cited by 500 · see citing works
Tano, K., Mizuno, R., Okada, T., Rakwal, R., Shibato, J., Masuo, Y., Ijiri, K., & Akimitsu, N. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.008 · Cited by 424 · see citing works
Moseley, M. L., Zu, T., Ikeda, Y., Gao, W., Mosemiller, A. K., Daughters, R. S., Chen, G., Weatherspoon, M. R., Clark, H. B., Ebner, T. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1827 · Cited by 422 · see citing works
Genomic imprinting at the mammalian Dlk1-Dio3 domain
da Rocha, S. T., Edwards, C. A., Ito, M., Ogata, T., & Ferguson‐Smith, A. C. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.03.011 · Cited by 407 · see citing works
Bond, A. M., VanGompel, M. J. W., Sametsky, E. A., Clark, M. F., Savage, J. C., Disterhoft, J. F., & Kohtz, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2371 · Cited by 399 · see citing works
Barry, G., Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Ratnu, V. S., Nayler, S. P., Nones, K., Hu, J., Bredy, T. W., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.45 · Cited by 394 · see citing works
Cabianca, D. S., Casà, V., Bodega, B., Xynos, A., Ginelli, E., Tanaka, Y., & Gabellini, D. (2012) · Cell · doi:10.1016/j.cell.2012.03.035 · Cited by 393 · see citing works
Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
Mercer, T. R., Qureshi, I., Gökhan, Ş., Dinger, M. E., Li, G., Mattick, J. S., & Mehler, M. F. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-14 · Cited by 390 · see citing works
Localization of the X inactivation centre on the human X chromosome in Xq13
Brown, C. J., Lafrenière, R. G., Powers, V. E. C., Sebastio, G., Ballabio, A., Pettigrew, A. L., Ledbetter, D. H., Levy, E. R., Craig, I., & Willard, H. F. (1991) · Nature · doi:10.1038/349082a0 · Cited by 389 · see citing works
RNA regulation of epigenetic processes
Mattick, J. S., Amaral, P., Dinger, M. E., Mercer, T. R., & Mehler, M. F. (2009) · BioEssays · doi:10.1002/bies.080099 · Cited by 381 · see citing works
Ponjavic, J., Oliver, P. L., Lunter, G. A., & Ponting, C. P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000617 · Cited by 368 · see citing works
Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors
Niinuma, T., Suzuki, H., Nojima, M., Nosho, K., Yamamoto, H., Takamaru, H., Yamamoto, E., Maruyama, R., Nobuoka, T., Miyazaki, Y., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1803 · Cited by 353 · see citing works
Brosius, J. (1999) · Gene · doi:10.1016/s0378-1119(99)00227-9 · Cited by 345 · see citing works
Long noncoding RNAs in cell biology
Clark, M. B., & Mattick, J. S. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.01.001 · Cited by 333 · see citing works
RNA‐Seq: A Method for Comprehensive Transcriptome Analysis
Nagalakshmi, U., Waern, K., & Snyder, M. P. (2010) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0411s89 · Cited by 319 · see citing works
Dendritic BC200 RNA in aging and in Alzheimer's disease
Mus, E., Hof, P. R., & Tiedge, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701532104 · Cited by 311 · see citing works
The Dlk1 and Gtl2 genes are linked and reciprocally imprintedPreprint
Schmidt, J. V., Matteson, P. G., Jones, B. K., Guan, X.-J., & Tilghman, S. M. (2000) · Genes & Development · doi:10.1101/gad.14.16.1997 · Cited by 310 · see citing works
The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage
Zhang, A., Zhou, N., Huang, J., Liu, Q., Fukuda, K., Ma, D., Lü, Z., Bai, C., Watabe, K., & Mo, Y. (2012) · Cell Research · doi:10.1038/cr.2012.164 · Cited by 301 · see citing works
The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1
Lyle, R., Watanabe, D., Vruchte, D. T., Lerchner, W., Smrzka, O. W., Wutz, A., Schageman, J. J., Hahner, L., Davies, C., & Barlow, D. P. (2000) · Nature Genetics · doi:10.1038/75546 · Cited by 288 · see citing works
RNA Gain-of-Function in Spinocerebellar Ataxia Type 8
Daughters, R. S., Tuttle, D. L., Gao, W., Ikeda, Y., Moseley, M. L., Ebner, T. J., Swanson, M. S., & Ranum, L. P. W. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000600 · Cited by 278 · see citing works
Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a
Yamasaki, K. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg106 · Cited by 273 · see citing works
Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
Bhan, A., Hussain, I., Ansari, K. I., Kasiri, S., Bashyal, A., & Mandal, S. S. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.022 · Cited by 263 · see citing works
Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness
Marques, A. C., & Ponting, C. P. (2009) · Genome biology · doi:10.1186/gb-2009-10-11-r124 · Cited by 255 · see citing works
Ladd, P. D., Smith, L. E., Rabaia, N. A., Moore, J. M., Georges, S. A., Hansen, R. S., Hagerman, R. J., Tassone, F., Tapscott, S. J., & Filippova, G. N. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm293 · Cited by 248 · see citing works
Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control
Lee, J. T. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3231 · Cited by 221 · see citing works
Amaral, P. P., Neyt, C., Wilkins, S. J., Askarian-Amiri, M. E., Sunkin, S. M., Perkins, A. C., & Mattick, J. S. (2009) · RNA · doi:10.1261/rna.1705309 · Cited by 209 · see citing works
Chamberlain, S. J., & Brannan, C. I. (2001) · Genomics · doi:10.1006/geno.2001.6543 · Cited by 204 · see citing works
Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development
Brandon, N. J., Millar, J. K., Korth, C., Sive, H., Singh, K. K., & Sawa, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3355-09.2009 · Cited by 198 · see citing works
Williamson, C. M., Turner, M. D., Ball, S. T., Nottingham, W. T., Glenister, P. H., Fray, M., Tymowska‐Lalanne, Z., Plagge, A., Powles-Glover, N. S., Kelsey, G., et al. (2006) · Nature Genetics · doi:10.1038/ng1731 · Cited by 196 · see citing works
Metabolic differentiation in the embryonic retina
Agathocleous, M., Love, N. K., Randlett, O., Harris, J. J., Liu, J., Murray, A. J., & Harris, W. A. (2012) · Nature Cell Biology · doi:10.1038/ncb2531 · Cited by 182 · see citing works
A Novel RNA Transcript with Antiapoptotic Function Is Silenced in Fragile X Syndrome
Khalil, A. M., Faghihi, M. A., Modarresi, F., Brothers, S. P., & Wahlestedt, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001486 · Cited by 172 · see citing works
Lin, D., Pestova, T. V., Hellen, C. U. T., & Tiedge, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01800-07 · Cited by 171 · see citing works
BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.
Martignetti, J. A., & Brosius, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11563 · Cited by 149 · see citing works
Kondrashov, A. V., Kiefmann, M., Ebnet, K., Khanam, T., Muddashetty, R. S., & Brosius, J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.07.049 · Cited by 118 · see citing works
Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease
Johnson, R., Richter, N., Jauch, R., Gaughwin, P. M., Zuccato, C., Cattaneo, E. F., & Stanton, L. W. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00019.2010 · Cited by 117 · see citing works
Modulating the Expression of Disease Genes with RNA-Based Therapy
Wood, M. J. A., Yin, H., & McClorey, G. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030109 · Cited by 98 · see citing works
Johnstone, K. A., DuBose, A. J., Futtner, C. R., Elmore, M. D., Brannan, C. I., & Resnick, J. L. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi456 · Cited by 88 · see citing works
Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation
Tochitani, S., & Hayashizaki, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.127 · Cited by 86 · see citing works
Control of RNA processing by a large non-coding RNA over-expressed in carcinomas
Lin, R., Roychowdhury-Saha, M., Black, C., Watt, A. T., Marcusson, E. G., Freier, S. M., & Edgington, T. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.01.030 · Cited by 85 · see citing works
Kanduri, C., Thakur, N., & Pandey, R. R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601090 · Cited by 79 · see citing works
RAMPAGE: Promoter Activity Profiling by Paired-End Sequencing of 5′-Complete cDNAs
Batut, P. J., & Gingeras, T. (2013) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb25b11s104 · Cited by 79 · see citing works
HELLP babies link a novel lincRNA to the trophoblast cell cycle
van Dijk, M., Thulluru, H. K., Mulders, J., Michel, O. J., Poutsma, A., Windhorst, S., Kleiverda, G., Sie, D., Lachmeijer, A. M. A., & Oudejans, C. B. M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65171 · Cited by 69 · see citing works
A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder
Williams, J. M., Beck, T., Pearson, D. M., Proud, M. B., Cheung, S. W., & Scott, D. A. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32941 · Cited by 62 · see citing works
New meaning in the message: Noncoding RNAs and their role in retinal development
Rapicavoli, N. A., & Blackshaw, S. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21844 · Cited by 55 · see citing works
As Antisense RNA Gets Intronic
Reis, E. M. R., Louro, R., Nakaya, H. I., & Verjovski‐Almeida, S. (2005) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2005.9.2 · Cited by 49 · see citing works
Enhanced Reprogramming of Xist by Induced Upregulation of Tsix and Dnmt3a
Tae, J., Han, D., Gentile, L., Sobek-Klocke, I., Stehling, M., & Schöler, H. R. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0482 · Cited by 33 · see citing works
Ntab, a novel non-coding RNA abundantly expressed in rat brain
French, P. J., Bliss, T., & O'Connor, V. M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00408-0 · Cited by 29 · see citing works
Biomarkers for Huntington's disease: an update
Scahill, R. I., Wild, E. J., & Tabrizi, S. J. (2012) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2012.701205 · Cited by 11 · see citing works
Angelman Syndrome Scientific Symposium on the Structure and Function of UBE3A/E6AP
Williams, C. A. (2009) · Journal of Child Neurology · doi:10.1177/0883073809332767 · Cited by 6 · see citing works
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Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches
Qian, X., Zhao, J., Yeung, P. Y., Zhang, Q. C., & Kwok, C. K. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.09.012 · Cited by 436 · see citing works
The functional role of long non-coding RNAs and epigenetics
Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 359 · see citing works
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
Bhan, A., & Mandal, S. S. (2014) · ChemMedChem · doi:10.1002/cmdc.201300534 · Cited by 283 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“302 Highly expression of lncRNAs in the brain is crucial for maintaining neural stem cells, neurogenesis, neural plasticity and cognitive function, etc. 303 For example, brain cytoplasmic lncRNA (BC1), one of the earliest lncRNAs studied in the brain, regulates metabotropic receptor signaling.”
BackgroundSaha, S. S., Mandal, P., Sadhukhan, T., Chowdhury, R. R., Mondal, N. R., Chakravarty, B., Chatterjee, T., Roy, S. S., & Sengupta, S. (2015) · Scientific Reports · doi:10.1038/srep11724 · Cited by 192 · see citing works
Wang, Q., Zhang, J., Liu, Y., Zhang, W., Zhou, J., Duan, R., Pu, P., Kang, C., & Han, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.01.039 · Cited by 182 · see citing works
Dykstra-Aiello, C., Jickling, G. C., Ander, B. P., Shroff, N., Zhan, X., Liu, D., Hull, H., Orantia, M., Stamova, B. S., & Sharp, F. R. (2016) · Stroke · doi:10.1161/strokeaha.116.013869 · Cited by 139 · see citing works
Griffiths, B. B., & Hunter, R. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.041 · Cited by 111 · see citing works
Genome-wide differential expression of synaptic long noncoding RNAs in autism spectrum disorder
Wang, Y., Zhao, X., Ju, W., Flory, M. J., Zhong, J. L., Jiang, S., Wang, P., Dong, X., Tao, X., Chen, Q., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.144 · Cited by 97 · see citing works
The link between long noncoding RNAs and depression
Huang, X., Luo, Y., Mao, Y.-S., & Jian-lin, J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.004 · Cited by 92 · see citing works
Fenoglio, C., Scarpini, E. A., Serpente, M., & Galimberti, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170702 · Cited by 82 · see citing works
Self-citationEpigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation
Podobińska, M., Szabłowska‐Gadomska, I., Augustyniak, J., Sandvig, I., Sandvig, A., & Bużańska, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00023 · Cited by 79 · see citing works
Sun, X., Huang, T., Liu, Z., Sun, M., & Luo, S. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172407 · Cited by 79 · see citing works
Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells
Shi, Y.-G., Lu, J., Zhou, J., Tan, X., He, Y., Ding, J., Tian, Y., Wang, L., & Wang, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.144 · Cited by 78 · see citing works
Butler, A. A., Webb, W. M., & Lubin, F. D. (2015) · Epigenomics · doi:10.2217/epi.15.79 · Cited by 67 · see citing works
Biomarkers and the Development of a Personalized Medicine Approach in Spinal Muscular Atrophy
Kariyawasam, D. S. T., D’Silva, A., Lin, C. S.-Y., Ryan, M. M., & Farrar, M. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00898 · Cited by 69 · see citing works
Update on Biomarkers in Spinal Muscular Atrophy
Pino, M. G., Rich, K. A., & Kolb, S. J. (2021) · Biomarker Insights · doi:10.1177/11772719211035643 · Cited by 61 · see citing works
Bao, J., Zhou, C., Zhang, J., Mo, J.-Q., Ye, Q., He, J., & Diao, J. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170260 · Cited by 50 · see citing works
Zhuang, J., Cai, P., Chen, Z., Yang, Q., Chen, X., Wang, X., & Zhuang, X. (2020) · PubMed Central · Cited by 41 · see citing works
Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R. (2022) · Cells · doi:10.3390/cells11121930 · Cited by 39 · see citing works
Molecular mechanisms of long ncRNAs in neurological disorders
Vučićević, D., Schrewe, H., & Ørom, U. A. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00048 · Cited by 39 · see citing works
Liu, J., Cheng, G., Yang, H., Deng, X., Qin, C., Hua, L., & Yin, C. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5443 · Cited by 38 · see citing works
Chen, Y., Huang, C., Zhu, S., Hong-chang, Z., Xu, C., & Chen, Y.-X. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04164-8 · Cited by 38 · see citing works
Associating schizophrenia, long non-coding RNAs and neurostructural dynamics
Merelo, V., Durand, D., Lescallette, A. R., Vrana, K. E., Hong, L. E., Faghihi, M. A., & Bellon, A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00057 · Cited by 37 · see citing works
Bountali, A., Tonge, D. P., & Mourtada‐Maarabouni, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.005 · Cited by 37 · see citing works
MYC-driven regulation of long non-coding RNA profiles in breast cancer cells
Tokgün, P. E., Tokgün, O., Kurt, S., Tomatir, A. G., & Akça, H. (2019) · Gene · doi:10.1016/j.gene.2019.143955 · Cited by 36 · see citing works
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Salemi, M., Lanza, G., Mogavero, M. P., Cosentino, F., Borgione, E., Iorio, R., Ventola, G. M., Marchese, G., Salluzzo, M. G., Ravo, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031535 · Cited by 32 · see citing works
Long noncoding RNAs in cervical cancer
Shi, D., Zhang, C., & Liu, X. (2018) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_669_17 · Cited by 29 · see citing works
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Yang, L., Wang, B., Ma, L., & Fu, P. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.849403 · Cited by 24 · see citing works
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Zhou, C., Rao, X., Wang, H., Zeng, B., Yu, Y., Chen, J., Zhong, J., Qi, X., Zeng, L., Zheng, P., et al. (2020) · Functional & Integrative Genomics · doi:10.1007/s10142-019-00716-w · Cited by 25 · see citing works
Chen, M., Wang, J., Luo, Y., Huang, K., Shi, X., Liu, Y., Li, J., Lai, Z., Xue, S., Gao, H., et al. (2018) · Human Genomics · doi:10.1186/s40246-018-0133-y · Cited by 20 · see citing works
Tang, Q., Hu, X. T., Qiong, G., Shi, Y., Liu, L., & Ying, G. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.704988 · Cited by 15 · see citing works
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Kuang, L., Zhao, H., Wang, L., Xuan, Z., & Pei, T. (2018) · Current Bioinformatics · doi:10.2174/1574893613666181026122045 · Cited by 12 · see citing works
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Verdone, L., Caserta, M., Ben‐Soussan, T. D., & Venditti, S. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2022.12.009 · Cited by 12 · see citing works
Wang, C., Yang, Y. F., Cong, L., Jiang, Y., Du, N., & Zhang, H. (2021) · Microvascular Research · doi:10.1016/j.mvr.2021.104225 · Cited by 11 · see citing works
Li, X., Chen, F., Ju, J., Yin, X., Yang, Z., Li, Z., & Sun, Q. (2023) · Inflammation · doi:10.1007/s10753-023-01800-x · Cited by 10 · see citing works
Epigenetic regulatory modifications in genetic and sporadic frontotemporal dementia
Fenoglio, C., Scarpini, E. A., & Galimberti, D. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1481389 · Cited by 10 · see citing works
Self-citationHierarchical natural move Monte Carlo refines flexible RNA structures into cryo-EM densities
Chang, J.-Y., Cui, Z., Yang, K., Huang, J., Mináry, P., & Zhang, J. (2020) · RNA · doi:10.1261/rna.071100.119 · Cited by 10 · see citing works
Long Non-Coding RNA HULC Promotes Progression of Bone Neoplasms
Zhang, T., Wan, C., Mei, X.-L., Jia, P., & Wang, M.-J. (2018) · Medical Science Monitor · doi:10.12659/msm.910220 · Cited by 9 · see citing works
Role of long non-coding RNAs in Down syndrome patients: a transcriptome analysis study
Salemi, M., Cannarella, R., Marchese, G., Salluzzo, M. G., Ravo, M., Barone, C., Giudice, M. L., Calogero, A. E., & Romano, C. (2021) · Human Cell · doi:10.1007/s13577-021-00602-3 · Cited by 9 · see citing works
Frías-Lasserre, D., Villagra, C., & Guerrero‐Bosagna, C. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00143 · Cited by 10 · see citing works
Shi, Z., Wu, Y., Zhuo, Q., Zuo, Y., Lin, J., Shi, H., Zhou, H., & Xu, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-34909-y · Cited by 8 · see citing works
Identification of long non-coding RNA in formaldehyde-induced cardiac dysplasia in rats
Zhang, L., Yang, Y., Zhang, L., Ma, J., Sun, R., Tian, Y., Yuan, X., Liu, B., Yu, T., & Jiang, Z. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113653 · Cited by 7 · see citing works
Zhu, F., Luo, E., Yi, F., Xiong, J., Huang, C., & Li, R. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001732 · Cited by 7 · see citing works
The Biology of Long Non-Coding RNA
McKiernan, P. J., & Greene, C. M. (2014) · Springer eBooks · doi:10.1007/978-3-319-13689-9_2 · Cited by 7 · see citing works
Rizzo, A., Alfei, E., Zibordi, F., Saletti, V., Zorzi, G. S., Freri, E., Estienne, M., Girgenti, V., D’Arrigo, S., Esposito, S., et al. (2018) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32649 · Cited by 6 · see citing works
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Qasim, H., Khattab, K., Shugaer, M. A., & Varrassi, G. (2025) · Cureus · doi:10.7759/cureus.90188 · Cited by 5 · see citing works
Xin, X., Zhang, Y., Gao, C.-Q., Min, H., Wang, L., & Du, P.-F. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.864564 · Cited by 5 · see citing works
Remodeling the Epigenome Through Meditation: Effects on Brain, Body, and Well-being
Venditti, S. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_7 · Cited by 5 · see citing works
Message in hand: the application of CRISPRi, RNAi, and LncRNA in adenocarcinoma
Wang, T., Yao, Y., Hu, X., & Zhao, Y. (2022) · Medical Oncology · doi:10.1007/s12032-022-01727-7 · Cited by 4 · see citing works
lincR-Ccr2-5′AS and THRIL as potential biomarkers of multiple sclerosis
Shaker, O. G., Hassan, A., Mohammed, A., & Mohammed, S. R. (2021) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-021-00151-2 · Cited by 4 · see citing works
Long Noncoding RNA ( lncRNA ): Functions in Health and Disease
Bhan, A., Soleimani, M., & Mandal, S. S. (2017) · doi:10.1002/9783527697274.ch6 · Cited by 4 · see citing works
Long Noncoding RNA s and Tumorigenesis
Matjašič, A., & Glavač, D. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0025688 · Cited by 3 · see citing works
Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System
Fenoglio, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-72938-1_1 · Cited by 2 · see citing works
Self-citationLong Noncoding RNA: Genomics and Relevance to Physiology
Kong, Y., Lu, Z., Liu, P., Liu, Y., Wang, F., Liang, E. Y., Hou, F. F., & Liang, M. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00085.x · Cited by 2 · see citing works
miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients
Wang, X., Li, L., Chen, Z., Zeng, Y., Shu, P., Hou, L., Yin, B., Liu, W., & Peng, X. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102927 · Cited by 1 · see citing works
Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitus
Surendran, S., & Kartha, C. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_15 · Cited by 1 · see citing works
Asgari, Y., Heng, J. I., Lovell, N. H., Forrest, A. R. R., & Alinejad‐Rokny, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.16.087395
RNA sequencing of non-coding RNAs in ischaemic heart disease
Ward, Z. (2021) · Otago University Research Archive (University of Otago)
Yang, X., Qiao, R., Ni, N., Zhang, Q., Zhang, K., Shao, X., Cheng, W., Sun, J., & Jiang, Y. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s357755
Sun, J., Li, Z.-K., Wang, X., Zhang, C., & Li, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2773876/v1
Sun, J., Li, Z., Wang, X., Jia, J., Wu, Q., Zhang, C., & Li, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2773876/v2
Down-regulation of Long Non-coding RNA H19 and ADCK4 gene in Children with Nephrotic SyndromePreprint
Asar, M., Elmalawany, A. M., Zaid, A., Atlam, S., El‐Torgoman, A. M., Mohamed, S. K., & El-Naidany, S. S. (2024) · Research Square · doi:10.21203/rs.3.rs-4883076/v1
Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression
Alhammad, R., Allison, M., Alhammad, F., & Anene, C. A. (2024) · Diagnostics · doi:10.3390/diagnostics14192227
Identification of host lncRNAs that impact Venezuelan equine encephalitis virus TC-83 replication
Behnia, M., Ye, C., Somfleth, K. Y., Oyebamiji, O., Brayer, K. J., Guo, Y., Ness, S. A., Savan, R., & Bradfute, S. B. (2026) · Journal of Virology · doi:10.1128/jvi.01353-25
- Authors
- Fenoglio, C., Ridolfi, E., Galimberti, D., & Scarpini, E.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Fenoglio, Chiara
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-10-14
- Volume
- 14
- Issue
- 10
- Pages
- 20427-20442
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3821623
- OpenAlex
- W2058341942
- Cited by
- 68
- References
- 94
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- long non-coding RNA, lncRNA dysregulation, neurological disorders, chromatin regulation, dosage compensation, genomic imprinting, stem cell pluripotency, cell fate determination, disease mechanisms
- MeSH terms
- Animals, Humans, Nervous System Diseases, RNA, Long Noncoding
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