Activation of Src kinase in primary colorectal carcinoma: An indicator of poor clinical prognosis

Nonparametric Estimation from Incomplete Observations

Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239

Regression Models and Life-Tables

Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793

Regression Models and Life-Tables

Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297

Classification and Regression Trees.

Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,867

Classification and Regression Trees.

Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030

BMDP Statistical Software 1981.

Bubolz, T. A., & Dixon, W. J. (1984) · Journal of the American Statistical Association · doi:10.2307/2288308 · Cited by 5,231

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537

Presalvage prostate‐specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy

Spiess, P. E., Lee, A. K., Leibovici, D., Wang, X., Do, K.-A., & Pisters, L. L. (2006) · Cancer · doi:10.1002/cncr.21979 · Cited by 1,930

Molecular themes in oncogenesis

Bishop, J. M. (1991) · Cell · doi:10.1016/0092-8674(91)90636-d · Cited by 1,629

Activating SRC mutation in a subset of advanced human colon cancers

Irby, R. B., Mao, W., Coppola, D., Kang, J., Loubeau, J. M., Trudeau, W., Karl, R., Fujita, D. J., Jove, R., & Yeatman, T. J. (1999) · Nature Genetics · doi:10.1038/5971 · Cited by 489

Src family kinases in tumor progression and metastasis

Summy, J. M., & Gallick, G. E. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023772912750 · Cited by 827

The Role of Src in Solid Tumors

Wheeler, D. L., Iida, M., & Dunn, E. F. (2009) · The Oncologist · doi:10.1634/theoncologist.2009-0009 · Cited by 346

Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells

Hiscox, S., Morgan, L. D., Green, T. P., Barrow, D., Gee, J. M. W., & Nicholson, R. I. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9120-9 · Cited by 275

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades

Lu, Y., Yu, Q., Liu, J. H., Zhang, J., Wang, H., Koul, D., McMurray, J. S., Fang, X., Yung, W. K. A., Siminovitch, K. A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303621200 · Cited by 264

Tyrosine kinase inhibitors in cancer therapy

Madhusudan, S., & Ganesan, T. S. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.05.006 · Cited by 236

Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells by Inhibition of NF-κB and Src Protein Kinase Signaling Pathways

Shakibaei, M., Mobasheri, A., Lueders, C., Busch, F., Shayan, P., & Goel, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057218 · Cited by 228

Treatment for Advanced Tumors: Src Reclaims Center Stage

Summy, J. M., & Gallick, G. E. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2692 · Cited by 224

Src activation regulates anoikis in human colon tumor cell lines

Windham, T. C., Parikh, N. U., Siwak, D. R., Summy, J. M., McConkey, D. J., Kraker, A. J., & Gallick, G. E. (2002) · Oncogene · doi:10.1038/sj.onc.1205989 · Cited by 219

Molecular Mechanisms of Resistance to Therapies Targeting the Epidermal Growth Factor Receptor

Camp, E. R., Summy, J. M., Bauer, T. W., Liu, W., Gallick, G. E., & Ellis, L. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.397.11.1 · Cited by 210

Inhibition of Src Expression and Activity Inhibits Tumor Progression and Metastasis of Human Pancreatic Adenocarcinoma Cells in an Orthotopic Nude Mouse Model

Trevino, J. G., Summy, J. M., Lesslie, D. P., Parikh, N. U., Hong, D. S., Lee, F. Y., Donato, N. J., Abbruzzese, J. L., Baker, C. H., & Gallick, G. E. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050570 · Cited by 206

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

Baker, A., Cox, T. R., Bird, D., Lang, G., Murray, G. I., Sun, X., Southall, S. M., Wilson, J. R., & Erler, J. T. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq569 · Cited by 206

Src kinase phosphorylates Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression

Cursi, S., Rufini, A., Stagni, V., Condò, I., Matafora, V., Bachi, A., Bonifazi, A. P., Coppola, L., Superti‐Furga, G., Testi, R., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601085 · Cited by 205

Invading one step at a time: the role of invadopodia in tumor metastasis

Paz, H., Pathak, N., & Yang, J. (2013) · Oncogene · doi:10.1038/onc.2013.393 · Cited by 208

The role of Src in prostate cancer

Fizazi, K. S. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm086 · Cited by 184

Using Kaplan–Meier analysis together with decision tree methods (C&RT, CHAID, QUEST, C4.5 and ID3) in determining recurrence-free survival of breast cancer patients

Türe, M., Tokatlı, F., & Ömürlü, İ. K. (2007) · Expert Systems with Applications · doi:10.1016/j.eswa.2007.12.002 · Cited by 179

Activated Src Protein Tyrosine Kinase Is Overexpressed in Late-Stage Human Ovarian Cancers

Wiener, J. R., Windham, T. C., Estrella, V. C., Parikh, N. U., Thall, P. F., Deavers, M. T., Bast, R. C., Mills, G. B., & Gallick, G. E. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6851 · Cited by 175

Regulation of cell structure and function by actin‐binding proteins: Villin's perspective

Khurana, S., & George, S. P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.040 · Cited by 176

Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Plé, P. A., Green, T. P., Hennequin, L. F., Curwen, J., Fennell, M., Allen, J. M., der Brempt, C. L., & Costello, G. F. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030317k · Cited by 170

SRC gene expression in human cancer: the role of transcriptional activation

Dehm, S. M., & Bonham, K. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-077 · Cited by 169

Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress

Kopetz, S., Lesslie, D. P., Dallas, N. A., Park, S. I., Johnson, M., Parikh, N. U., Kim, M. P., Abbruzzese, J. L., Ellis, L. M., Chandra, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2246 · Cited by 160

Phase II Trial of Saracatinib (AZD0530), an Oral SRC-inhibitor for the Treatment of Patients with Hormone Receptor-negative Metastatic Breast Cancer

Gucalp, A., Sparano, J. A., Caravelli, J. F., Santamauro, J. T., Patil, S. N., Abbruzzi, A., Pellegrino, C. M., Bromberg, J., Dang, C. T., Theodoulou, M., et al. (2011) · Clinical Breast Cancer · doi:10.1016/j.clbc.2011.03.021 · Cited by 159

Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

Nautiyal, J., Kanwar, S. S., Yu, Y., & Majumdar, A. P. N. (2011) · Journal of Molecular Signaling · doi:10.1186/1750-2187-6-7 · Cited by 149

Direct cysteine sulfenylation drives activation of the Src kinase

Heppner, D. E., Dustin, C. M., Liao, C., Hristova, M., Veith, C., Little, A. C., Ahlers, B. A., White, S. L., Deng, B., Lam, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06790-1 · Cited by 142

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

Dunn, E. F., Iida, M., Myers, R. A., Campbell, D. A., Hintz, K. A., Armstrong, E. A., Li, C., & Wheeler, D. L. (2011) · Oncogene · doi:10.1038/onc.2010.430 · Cited by 133

SKI-606, a Src/Abl Inhibitor with In vivo Activity in Colon Tumor Xenograft Models

Golas, J. M., Lucas, J., Etienne, C., Golas, J., Discafani, C., Sridharan, L., Boghaert, E., Arndt, K., Ye, F., Boschelli, D. H., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2484 · Cited by 134

Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

Lesslie, D. P., Summy, J. M., Parikh, N. U., Fan, F., Trevino, J., Sawyer, T. K., Metcalf, C. A., Shakespeare, W. C., Hicklin, D. J., Ellis, L. M., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603143 · Cited by 126

The Role of Src in Colon Cancer and Its Therapeutic Implications

Chen, J., Elfiky, A. A., Han, M., Chen, C., & Saif, M. W. (2013) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2013.10.003 · Cited by 129

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

Serrels, A., Macpherson, I. R., Evans, T. R. J., Lee, F. Y., Clark, E. A., Sansom, O. J., Ashton, G. H. S., Frame, M. C., & Brunton, V. G. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0382 · Cited by 126

Progress towards the development of SH2 domain inhibitors

Kraskouskaya, D., Duodu, E., Arpin, C. C., & Gunning, P. T. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35449k · Cited by 115

Src continues aging: current and future clinical directions

Kopetz, S., Shah, A. N., & Gallick, G. E. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1902 · Cited by 111

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Nagathihalli, N. S., Beesetty, Y., Lee, W., Washington, M. K., Chen, X., Lockhart, A. C., & Merchant, N. B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2329 · Cited by 112

Src Family Kinases: Potential Targets for the Treatment of Human Cancer and Leukemia

Warmuth, M., Damoiseaux, R. D., Liu, Y., Fabbro, D., & Gray, N. S. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454126 · Cited by 111

The role of Src in solid and hematologic malignancies

Álvarez, R. H., Kantarjian, H. M., & Cortes, J. E. (2006) · Cancer · doi:10.1002/cncr.22215 · Cited by 105

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

Nagathihalli, N. S., Smith, J. J., Revetta, F. L., Washington, M. K., & Merchant, N. B. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1212 · Cited by 102

Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and β-Catenin

Saud, S. M., Young, M. R., Jones‐Hall, Y., Ileva, L. V., Evbuomwan, M. O., Wise, J., Colburn, N. H., Kim, Y. S., & Bobe, G. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0525 · Cited by 102

Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells.

Laird, A., Li, G., Moss, K. G., Blake, R. A., Broome, M. A., Cherrington, J. M., & Mendel, D. B. (2003) · PubMed · Cited by 101

A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study

Lara, P. N., Longmate, J., Evans, C. P., Quinn, D. I., Twardowski, P. W., Chatta, G. S., Posadas, E. M., Stadler, W. M., & Gandara, D. R. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328325a867 · Cited by 95

Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma.

Han, L. Y., Landen, C., Trevino, J., Halder, J., Lin, Y. G., Kamat, A. A., Kim, T.-J., Merritt, W., Coleman, R., Gershenson, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1410 · Cited by 91

Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies

Tortora, G., Bianco, R., Daniele, G., Ciardiello, F., McCubrey, J. A., Ricciardi, M. R., Ciuffreda, L., Cognetti, F., Tafuri, A., & Milella, M. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.03.003 · Cited by 91

Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines.

Golubovskaya, V., Gross, S., Kaur, A. S., Wilson, R. I., Xu, L., Yang, X. H., & Cance, W. G. (2003) · PubMed · Cited by 91

Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

Jin, W. (2020) · Cancers · doi:10.3390/cancers12051339 · Cited by 86

The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy

Lieu, C. H., & Kopetz, S. (2010) · Clinical Colorectal Cancer · doi:10.3816/ccc.2010.n.012 · Cited by 87

Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways

Read, R. D., Bach, E. A., & Cagan, R. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6676-6689.2004 · Cited by 87

The sensors and regulators of cell–matrix surveillance in anoikis resistance of tumors

Nagaprashantha, L. D., Vatsyayan, R., Lelsani, P. C. R., Awasthi, S., & Singhal, S. S. (2010) · International Journal of Cancer · doi:10.1002/ijc.25725 · Cited by 84

Update on Targets and Novel Treatment Options for High-Grade Osteosarcoma and Chondrosarcoma

van Oosterwijk, J. G., Anninga, J., Gelderblom, H. A. J., Cleton-Jansen, A., & Bovée, J. V. M. G. (2013) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2013.07.012 · Cited by 81

Targeting Signal Transduction Pathways in Colorectal Cancer—More Than Skin Deep

Cohen, S. J., Cohen, R. B., & Meropol, N. J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.194 · Cited by 84

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

Summy, J. M., Trevino, J. G., Lesslie, D. P., Baker, C. H., Shakespeare, W. C., Wang, Y., Sundaramoorthi, R., Metcalf, C. A., Keats, J. A., Sawyer, T. K., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0171 · Cited by 82

Bosutinib: A review of preclinical studies in chronic myelogenous leukaemia

Boschelli, F., Arndt, K. T., & Gambacorti-Passerini, C. B. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.032 · Cited by 80

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement

Serrels, A., Canel, M., Brunton, V. G., & Frame, M. C. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.4.17290 · Cited by 74

Src as the link between inflammation and cancer

Liu, S. T., Pham, H., Pandol, S. J., & Ptasznik, A. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00416 · Cited by 74

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer

Tian, Q., Yuan, P., Quan, C., Li, M., Xiao, J., Zhang, L., Lü, H., Ma, T., Zou, L., Wang, F., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1262-z · Cited by 73

Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Parseghian, C. M., Parikh, N. U., Wu, J. Y., Jiang, Z.-Q., Henderson, L., Tian, F., Pastor, B., Ychou, M., Raghav, K., Dasari, A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3138 · Cited by 67

Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors

Sharma, S., Singh, J., Ojha, R., Singh, H., Kaur, M., Bedi, P. M. S., & Nepali, K. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.02.018 · Cited by 70

Recurrent Genomic Alterations With Impact on Survival in Colorectal Cancer Identified by Genome-Wide Array Comparative Genomic Hybridization

Kim, M., Yim, S., Kwon, M., Kim, T., Shin, S., Kang, H. M., Lee, C., & Chung, Y. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.021 · Cited by 69

Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma

Homsi, J., Cubitt, C. L., Zhang, S., Münster, P. N., Yu, H., Sullivan, D. M., Jove, R., Messina, J. L., & DAUD, A. I. (2009) · Melanoma Research · doi:10.1097/cmr.0b013e328304974c · Cited by 69

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

van Oosterwijk, J. G., van Ruler, M. A. J. H., Bruijn, I. H. B., Herpers, B., Gelderblom, H. A. J., van de Water, B., & Bovée, J. V. M. G. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.451 · Cited by 68

The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein

Zhu, L., Qin, C., Li, T., Ma, X., Qiu, Y., Lin, Y., Ma, D., Qin, Z., Sun, C., Shen, X., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0464-9 · Cited by 66

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs

Rashed, M. H., Kanlikilicer, P., Rodriguez‐Aguayo, C., Pichler, M., Bayraktar, R., Bayraktar, E., Ivan, C., Filant, J., da Silva, A. M., Aslan, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15525 · Cited by 63

The relationship between tumour site, clinicopathological characteristics and cancer‐specific survival in patients undergoing surgery for colorectal cancer

Powell, A. G. M. T., Wallace, R., McKee, R. F., Anderson, J. H., Going, J. J., Edwards, J., & Horgan, P. G. (2012) · Colorectal Disease · doi:10.1111/j.1463-1318.2012.03048.x · Cited by 62

HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer

Chen, S., Chou, C., Chang, C.-C., Li, Y., Chen, S., Lin, I., Kok, S., Cheng, S., Lee, J., Wu, T., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13006 · Cited by 62

Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.

Sirvent, A., Bénistant, C., & Roche, S. (2012) · Europe PMC (PubMed Central) · Cited by 61

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

Liu, W., Kovačević, Ž., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P. J., Richardson, V., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5849 · Cited by 58

Targeting Src signaling in metastatic bone disease

Araujo, J. C., & Logothetis, C. J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23998 · Cited by 58

Effects of Src kinase inhibition induced by dasatinib in non–small cell lung cancer cell lines treated with cisplatin

Ceppi, P., Papotti, M. G., Monica, V., Iacono, M. L., Saviozzi, S., Pautasso, M., Novello, S., Mussino, S., Bracco, E., Volante, M., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0151 · Cited by 58

Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer

Hiscox, S., Morgan, L. D., Green, T., & Nicholson, R. I. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01297 · Cited by 57

The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation

Kuroiwa, M., Oneyama, C., Nada, S., & Okada, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.080291 · Cited by 59

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Temps, C., Lietha, D., Webb, E. R., Li, X., Dawson, J. C., Muir, M., MacLeod, K. G., Valero, T., Munro, A. F., Contreras‐Montoya, R., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0613 · Cited by 54

Src, chemoresistance and epithelial to mesenchymal transition: are they related?

Shah, A. N., & Gallick, G. E. (2007) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32801265d7 · Cited by 54

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells

Emaduddin, M., Bicknell, D. C., Bodmer, W. F., & Feller, S. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712176105 · Cited by 50

Srcasm Inhibits Fyn-Induced Cutaneous Carcinogenesis with Modulation of Notch1 and p53

Zhao, L., Li, W., Marshall, C. M., Griffin, T., Hanson, M., Hick, R. W., Dentchev, T., Williams, E. A., Werth, A. J., Miller, C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2976 · Cited by 55

miR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth.

Wang, N., Li, Q., Feng, N., Cheng, G., Guan, Z.-L., Wang, Y., Qin, C., Yin, C., & Hua, L. X. (2013) · Asian Journal of Andrology · doi:10.1038/aja.2013.80 · Cited by 59

Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer

Reddy, S. M., Kopetz, S., Morris, J. S., Parikh, N. U., Qiao, W., Overman, M. J., Fogelman, D. R., Shureiqi, I., Jacob, C., Malik, Z., et al. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0257-z · Cited by 55

Dasatinib in previously treated metastatic colorectal cancer: a phase II trial of the University of Chicago Phase II Consortium

Sharma, M. R., Wroblewski, K., Polite, B. N., Knost, J. A., Wallace, J. A., Modi, S., Sleckman, B. G., Taber, D., Vokes, E. E., Stadler, W. M., et al. (2012) · Investigational New Drugs · doi:10.1007/s10637-011-9681-x · Cited by 49

Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation

Shimozato, O., Waraya, M., Nakashima, K., Souda, H., Takiguchi, N., Yamamoto, H., Takenobu, H., Uehara, H., Ikeda, E., Matsushita, S., et al. (2014) · Oncogene · doi:10.1038/onc.2014.141 · Cited by 49

Activation of Abl Family Kinases in Solid Tumors

Ganguly, S. S., & Plattner, R. (2012) · Genes & Cancer · doi:10.1177/1947601912458586 · Cited by 49

Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer

Maurer, G. D., Leupold, J. H., Schewe, D. M., Biller, T., Kates, R. E., Hornung, H.-M., Lau‐Werner, U., Post, S., & Allgayer, H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1668 · Cited by 49

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

Torres‐Ayuso, P., Daza-Martín, M., Martı́n-Pérez, J., Ávila‐Flores, A., & Mérida, I. (2014) · Oncotarget · doi:10.18632/oncotarget.2344 · Cited by 48

Degradation of Epidermal Growth Factor Receptor Mediates Dasatinib-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma Cells

Lin, Y., Wu, M.-H., Wei, T.-T., Chung, S.-H., Chen, K., Cheng, A., & Chen, C. (2012) · Neoplasia · doi:10.1596/neo.12300 · Cited by 49

HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line

Yang, S. Z., Zhang, L. D., Zhang, Y., Xiong, Y., Zhang, Y., Li, H. L., Li, X. W., & Jia, D. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.079 · Cited by 48

The molecular rationale of Src inhibition in colorectal carcinomas

Gargalionis, A. N., Karamouzis, M. V., & Papavassiliou, A. G. (2014) · International Journal of Cancer · doi:10.1002/ijc.28299 · Cited by 47

Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis

Okuyama, H., Kondo, J., Sato, Y., Endo, H., Nakajima, A., Piulats, J. M., Tomita, Y., Fujiwara, T., Itoh, Y., Mizoguchi, A., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.011 · Cited by 47

Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways

Li, Y., Xi, Z., Chen, X., Cai, S., Liang, C., Wang, Z., Li, Y.-Y., Tan, H., Lao, Y., & Xu, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0574-1 · Cited by 46

Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2’, 4’-Tetrahydroxychalcone

Chen, C., Shenoy, A. K., Padia, R. N., Fang, D., Jing, Q., Yang, P., Su, S.-B., & Huang, S. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0902-4 · Cited by 47

Quantification of β-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry

Chen, Y., Gruidl, M., Remily-Wood, E. R., Liu, R. Z., Eschrich, S. A., Lloyd, M. C., Nasir, A., Bui, M. M., Huang, E. H., Shibata, D., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr1005197 · Cited by 45

Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle

Zhang, Y., Tu, Y., Zhao, J., Chen, K., & Wu, C. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810155 · Cited by 46

Potential Molecular Mechanism for c-Src Kinase-mediated Regulation of Intestinal Cell Migration

Mathew, S., George, S. P., Wang, Y., Siddiqui, M. R., Srinivasan, K., Tan, L., & Khurana, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801319200 · Cited by 44

Cigarette Smoke Activates the Proto-Oncogene c-Src to Promote Airway Inflammation and Lung Tissue Destruction

Geraghty, P. M., Hardigan, A. A., & Foronjy, R. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0258oc · Cited by 46

CD24 Induces Expression of the Oncomir miR-21 via Src, and CD24 and Src Are Both Post-Transcriptionally Downregulated by the Tumor Suppressor miR-34a

Muppala, S., Mudduluru, G., Leupold, J. H., Buergy, D., Sleeman, J. P., & Allgayer, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059563 · Cited by 44

Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors

Tintori, C., Magnani, M., Schenone, S., & Botta, M. (2008) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2008.07.002 · Cited by 44

Basis and Importance of SRC as a Target in Cancer

Levin, V. A. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_6 · Cited by 46

Divergent Roles of c-Src in Controlling Platelet-derived Growth Factor-dependent Signaling in Fibroblasts

Shah, K., & Vincent, F. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0263 · Cited by 43

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer

Campbell, E., McDuff, E., Tatarov, O., Tovey, S., Brunton, V., Cooke, T., & Edwards, J. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604768 · Cited by 50

ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer

Lim, E., Kang, J.-H., Kim, Y.-J., Kim, S., & Lee, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04862-1 · Cited by 42

Cooperative expression of junctional adhesion molecule‐C and ‐B supports growth and invasion of glioma

Tenan, M., Aurrand‐Lions, M., Widmer, V., Alimenti, A., Burkhardt, K., Lazeyras, F., Belkouch, M., Hammel, P., Walker, P. R., Duchosal, M. A., et al. (2009) · Glia · doi:10.1002/glia.20941 · Cited by 40

c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC

Ke, L., Xiang, Y., Guo, X., Lu, J., Xia, W., Yu, Y., Peng, Y., Wang, L., Wang, G., Ye, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8634 · Cited by 38

Src Induces Urokinase Receptor Gene Expression and Invasion/Intravasation via Activator Protein-1/p-c-Jun in Colorectal Cancer

Leupold, J. H., Asangani, I. A., Maurer, G. D., Lengyel, E. R., Post, S., & Allgayer, H. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0211 · Cited by 38

Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness

Boyd, D. D., Wang, H., Avila, H., Parikh, N. U., Kessler, H., Magdolen, V., & Gallick, G. E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1565-02 · Cited by 37

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

Xiao, J., Duan, Q., Wang, Z., Yan, W., Sun, H., Xue, P., Fan, X., Zeng, X., Chen, J., Shao, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8231 · Cited by 36

Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases

Creeden, J. F., Alganem, K., Imami, A. S., Brunicardi, F. C., Liu, S., Shukla, R., Tomar, T., Naji, F., & McCullumsmith, R. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228679 · Cited by 36

Mechanisms of resistance to EGFR inhibitors

Bianco, R., Gelardi, T., Damiano, V., Ciardiello, F., & Tortora, G. (2006) · Targeted Oncology · doi:10.1007/s11523-006-0038-x · Cited by 36

Prognostic relevance of Src activation in stage II-III colon cancer

Martínez-Pérez, J., Lopez-Calderero, I., Saez, C., Benavent, M., Limon, M. L., Gonzalez-Exposito, R., Soldevilla, B., Riesco-Martínez, M. C., Salamanca, J., Carnero, A., et al. (2017) · Human Pathology · doi:10.1016/j.humpath.2017.05.025 · Cited by 20

Untitled work

(1996) · PubMed · Cited by 63

Activación de Src quinasa: implicaciones predictivas y pronósticas en pacientes con cáncer de colon.

Martínez Pérez, J. E. (2018) · idUS (Universidad de Sevilla)

β-catenin mutation and overexpression in hepatocellular carcinoma

Wong, C., Fan, S. T., & Ng, I. O. (2001) · Cancer · doi:10.1002/1097-0142(20010701)92:1 · Cited by 353

Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer

Ganesh, S., Sier, C. F. M., HEERDING, M., van Krieken, J., Griffioen, G. G., Welvaart, K., van de Velde, C., Verheijen, J. H., Lamers, C. B. H. W., & Verspaget, H. W. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.306 · Cited by 40