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Cited by 124Cancer survivorship and carePalliative Care and End-of-Life IssuesPalliative and Oncologic Care

Anxiety disorders in advanced cancer patients: Correlates and predictors of end‐of‐life outcomes

Open access
Spencer, Ryan, Nilsson, Matthew, Wright, Alexi, Pirl, William, Prigerson, Holly·2010·Cancer
DOI 10.1002/cncr.24954PMC PMC2846995
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Abstract

BACKGROUND: The authors explored associations between anxiety disorders and advanced cancer patients' physical performance status, physician‐patient relationships, end‐of‐life (EOL) treatment preferences and outcomes, and quality of death. METHODS: The Coping with Cancer study was a National Cancer Institute/National Institute of Mental Health‐sponsored, prospective, longitudinal, multicenter cohort study of patients with advanced cancer. Six hundred thirty‐five patients completed the anxiety disorders module of the Structured Clinical Interview for the Diagnostic Statistical Manual IV. The results were compared with patients' baseline physical performance status, treatment preferences, perceptions of the physician‐patient relationship, and advance care planning (ACP). RESULTS: Approximately 7.6% of patients met criteria for an anxiety disorder. Patients who were diagnosed with an anxiety disorder were more likely to be women and younger and to have a worse physical performance status. Although there were no significant differences in patients' EOL treatment preferences or care, ACP, hospice enrollment, or patients' location of death, there were significant differences in how patients with anxiety disorders perceived the physician‐patient relationship. Patients with anxiety disorders had less trust in their physicians, felt less comfortable asking questions about their health, and felt less likely to understand the clinical information that their physicians presented. They also were more likely to believe that their physicians would offer them futile therapies and would not adequately control their symptoms. CONCLUSIONS: Women, patients who were more physically impaired, and younger patients with advanced cancer were more likely to meet criteria for an anxiety disorder. Patients with advanced cancer who had an anxiety disorder were more likely to experience greater challenges to the physician‐patient relationship. Cancer 2010. © 2010 American Cancer Society.

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  • No published data exist on how anxiolytics affect advanced cancer patients.

    “To our knowledge, there is no published data regarding the effects of anxiolytic treatment in advanced cancer patients (Spencer et al., 2010).”

    From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Spencer et al., 2010

    The Discussion says the authors were unaware of published randomized clinical trials of anxiety treatment in advanced cancer patients and calls for research on treatment effects. That supports a gap in trial evidence, but not the broader claim that no published data exist on the effects of anxiolytic drugs specifically. (LLM, conf=0.88)

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Research works printed but not linked: 3

  1. [17]First M Spitzer R Gibbon M Williams J Structured Clinical Interview for the DSM-IV Axis I Disorders – Patient Edition (SCID-I/P), ed. Version 2.0 1995 New York, NY Biometrics Research Department, New York State Psychiatric Institute
  2. [23]Bickley LS Bates Guide to Physical Examination and History Taking 2002 8th edition Philadelphia Lippincott, Williams and Wilkins
  3. [30]Tasman A Kay J Lieberman JA Psychiatry 2008 3rd edition West Sussex, England John Wiley & Sons

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Authors
Spencer, R., Nilsson, M., Wright, A., Pirl, W., & Prigerson, H.
Affiliations
  • Brigham and Women's Hospital (US)
  • Dana-Farber Cancer Institute (US)
  • Massachusetts General Hospital (US)
Corresponding author
Spencer, Ryan
ORCID
Venue
Cancer
Publisher
Wiley
Published
2010-02-24
Volume
116
Issue
7
Pages
1810-1819
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.24954
PMC
PMC2846995
OpenAlex
W2036737677
Cited by
124
References
34
Citations by year
2026: 6 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 7 · 2015: 3 · 2014: 11 · 2013: 9 · 2012: 12
FWCI
4.27
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH-63892, R01MH063892)
  • National Cancer Institute (R01CA106370, CA106370, U56CA118641, P30CA0651, P30CA006516)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Keywords
anxiety disorders, advanced cancer, physician-patient relationship, end-of-life treatment preferences, advance care planning, quality of death, trust in physicians, hospice enrollment, symptom management, psychological distress in cancer patients
MeSH terms
Activities of Daily Living, Adult, Aged, Aged, 80 and over, Anxiety Disorders, Female, Humans, Male, Middle Aged, Neoplasms, Physician-Patient Relations, Quality of Life, Surveys and Questionnaires, Terminal Care, Patient Preference, In Vitro Techniques

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