Global trends in intrahepatic and extrahepatic cholangiocarcinoma incidence from 1993 to 2012

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2. INTS8 is a therapeutic target for intrahepatic cholangiocarcinoma via the integration of bioinformatics analysis and experimental validation
   Qi Zhou, Ji Li, Xueying Shi, Dawei Deng, Fangyue Guo, Zhengpeng Wang, Wenhui Liu, Jinnan Zhang, Shilin Xia, Dong Shang · 2021 · Scientific Reports
3. Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis
   Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha’on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit et al. · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
4. The Emerging Role of MicroRNAs in Regulating the Drug Response of Cholangiocarcinoma
   Wen‐Kuan Huang, Chun‐Nan Yeh · 2020 · Biomolecules
5. Liver transplantation for malignant liver tumors
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6. Identification of RNF213 as a Potential Suppressor of Local Invasion in Intrahepatic Cholangiocarcinoma
   Khajeelak Chiablaem, Artit Jinawath, Jiratchaya Nuanpirom, Jantarika Kumar Arora, Sirawit Nasaree, Thanastha Thanomchard, Nilubon Singhto, Pamorn Chittavanich, Bhoom Suktitipat, Varodom Charoensawan et al. · 2024 · Laboratory Investigation
7. An MRI-based fusion model for preoperative prediction of perineural invasion status in patients with intrahepatic cholangiocarcinoma
   Zuochao Qi, Hao Yuan, Qingshan Li, Pengyu Chen, Dongxiao Li, Kunlun Chen, Bo Meng, Peigang Ning, Haibo Yu, Deyu Li · 2025 · World Journal of Surgical Oncology
8. Vimentin-Positive Circulating Tumor Cells as Diagnostic and Prognostic Biomarkers in Patients with Biliary Tract Cancer
   Sung Yong Han, Sung Hee Park, Hyun Suk Ko, Aelee Jang, Hyung Il Seo, So Jeong Lee, Gwang Ha Kim, Dong Uk Kim · 2021 · Journal of Clinical Medicine
9. Current Role and Future Perspectives of Immunotherapy and Circulating Factors in Treatment of Biliary Tract Cancers
   Simone Conci, Giovanni Catalano, Diletta Roman, Camilla Zecchetto, Eleonora Lucin, Mario De Bellis, Marzia Tripepi, Alfredo Guglielmi, Michèle Milella, Andrea Ruzzenente · 2023 · International Journal of Medical Sciences
10. Diagnosis and treatment of cholangiocarcinoma in Italy: A Delphi consensus statement
    Lorenza Rimassa, Giovanni Brandi, Monica Niger, Nicola Normanno, Davide Melisi · 2023 · Critical Reviews in Oncology/Hematology
11. Pemigatinib: A Review in Advanced Cholangiocarcinoma
    James E. Frampton · 2024 · Targeted Oncology
12. Predictive value of HTS grade in patients with intrahepatic cholangiocarcinoma undergoing radical resection: a multicenter study from China
    Guan Huang, Haofeng Zhang, Zhenwei Yang, Qingshan Li, Hao Yuan, Pengyu Chen, Chenxi Xie, Bo Meng, Xianzhou Zhang, Kunlun Chen et al. · 2024 · World Journal of Surgical Oncology
13. Efficacy analysis of HAIC combined with lenvatinib plus PD-1 inhibitor vs. first-line systemic chemotherapy for advanced intrahepatic cholangiocarcinoma
    Zhipeng Lin, Xugong Zou, Xiaolong Hu, Dabei Huang, Yuan Chen, Jiawen Lin, Xiaoqun Li, Jian Zhang · 2024 · Scientific Reports
14. Regorafenib, an investigational agent for the treatment of cholangiocarcinoma
    İbrahim Halil Şahin, Elaine S Tan, Richard D. Kim · 2020 · Expert Opinion on Investigational Drugs
15. MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5
    Da Wang, Junsheng Chen, Guanhua Wu, Fei Xiong, Wenzheng Liu, Qi Wang, Yiyang Kuai, Wenhua Huang, Yongqiang Qi, Bing Wang et al. · 2024 · Journal of Experimental & Clinical Cancer Research
16. Comparisons of global incidence and risk factor profiles of hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Tao Wu, Mingyi Du, Tiejun Zhang, Xingdong Chen, Zhenqiu Liu · 2025 · Annals of Hepatology
17. Predicting Disease-Specific Survival for Patients With Primary Cholangiocarcinoma Undergoing Curative Resection by Using a Decision Tree Model
    Bing Quan, Miao Li, Shenxin Lu, Jinghuan Li, Wenfeng Liu, Feng Zhang, Rongxin Chen, Zhenggang Ren, Xin Yin · 2022 · Frontiers in Oncology
18. Secular trends of intrahepatic cholangiocarcinoma in a high endemic area: A population-based study
    Chun-Ru Lin, Yu‐Kwang Lee, Chun‐Ju Chiang, Ya‐Wen Yang, Hung-Chuen Chang, San‐Lin You · 2022 · World Journal of Gastroenterology
19. Prognostic Nutritional Index Associates with Immunotherapy Response in Patients with Metastatic Biliary Tract Cancer
    Lei Yang, Juan Zhong, Wenbo Wang, Fuxiang Zhou · 2022 · Nutrition and Cancer
20. Real-world outcomes of chemotherapy plus immune checkpoint inhibitors versus chemotherapy alone in advanced, unresectable, and recurrent intrahepatic cholangiocarcinoma
    Tinotenda Blessing Madzikatire, Shan Heng, Hongyi Gu, Yunfeng Shan, En-Hua Lin, Joshua Banda, Asta Debora, Brandon Anotida Madziva, Mutale Jaeste Bowa, Munyaradzi Godfrey Mudhuri et al. · 2024 · Frontiers in Immunology
21. Atezolizumab: an investigational agent for the treatment of biliary tract cancer
    Stephen Paul Hack, Andrew Xiuxuan Zhu · 2021 · Expert Opinion on Investigational Drugs
22. Disability in perioperative activities of daily living is associated with worse survival outcomes following hepatic resection in patients with intrahepatic cholangiocarcinoma
    Kosuke Mima, Hiromitsu Hayashi, Shinsei Yumoto, Takashi Matsumoto, Masayo Tsukamoto, Tatsunori Miyata, Shigeki Nakagawa, Hidetoshi Nitta, Hideo Baba · 2022 · Hepatology Research
23. The Role of Surgical Resection and Liver Transplantation for the Treatment of Intrahepatic Cholangiocarcinoma
    Guergana G. Panayotova, Jarot J Guerra, James V. Guarrera, Keri E. Lunsford · 2021 · Journal of Clinical Medicine
24. Liver Transplantation for Incidental Cholangiocarcinoma or Combined Hepatocellular Carcinoma/Cholangiocarcinoma—Own Experiences and Review of the Literature
    Laura Schwenk, Oliver Rohland, Aladdin Ali Deeb, Felix Dondorf, Utz Settmacher, Falk Rauchfuß · 2023 · Cancers
25. Contemporary trends and outcomes after liver transplantation and resection for intrahepatic cholangiocarcinoma
    Thomas Clark Howell, Kristen Elizabeth Rhodin, Brian I. Shaw, Jiayin Bao, Elishama N. Kanu, Sabran J. Masoud, Alex J. Bartholomew, Qimeng Gao, Imran John Anwar, Joseph M. Ladowski et al. · 2024 · Journal of Gastrointestinal Surgery
26. A Systematic Review of Exercise-Based Cancer Rehabilitation Programs Worldwide: Availability and Content
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27. FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma
    Diyala S. Shihadih, Xue Wang, Peter‐James H. Zushin, Pavlo V. Khodakivskyi, Hyo Min Park, Emily Tso, Jena Shiblak, Angela Misic, Sharon M. Louie, Catherine Ward et al. · 2024 · Molecular Cancer Research
28. Epidemiological characteristics and precise prophylaxis and control of HBV-associated primary liver cancer
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29. Associations between metabolic syndrome and cholangiocarcinoma risk: A large-scale population-based cohort study
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30. Durable Response after Olaparib Treatment for Perihilar Cholangiocarcinoma with Germline BRCA2 Mutation
    Bruno Almeida Costa, Paulino Tallón de Lara, Wungki Park, Fergus Keane, James J. Harding, Danny N. Khalil · 2023 · Oncology Research and Treatment
31. Downregulation of JAM3 occurs in cholangiocarcinoma by hypermethylation: A potential molecular marker for diagnosis and prognosis
    Yi Ping Shi, Xiao Shan Feng, Ying Zhang, Ji Gao, Wei Bao, Jiandong Wang, Jian‐feng Bai · 2023 · Journal of Cellular and Molecular Medicine
32. Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice
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33. Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer
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34. Updated cholangiocarcinoma incidence trends and projections in Thailand by region based on data from four population-based cancer registries
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35. Integrating multi-omics in bile for biomarker discovery in cholangiocarcinoma
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36. Survival benefit and biomarker of PD‐1 inhibitor combination therapy in first‐line of advanced biliary tract cancer: A retrospective study
    Jingyi Guo, Qun Zhou, Mingzhen Zhou, Hengheng Dai, Lin Li, Yudong Qiu, Liang Mao, Baorui Liu, Jie Shen · 2023 · Cancer Medicine
37. Incidental findings of gallbladder and bile ducts – Management strategies: Normal findings, anomalies, “silent gallstones” and bile duct dilatation - A World Federation of Ultrasound in Medicine and Biology (WFUMB) position paper
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38. Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma
    Jiafen Xie, Xiaoming Wang · 2025 · World Journal of Surgical Oncology
39. IgG4 expression and IgG4/IgG ratio in the tumour invasion front predict long-term outcomes for patients with intrahepatic cholangiocarcinoma
    Takahiro Yoshizawa, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Yasuhiro Kinugawa, Akira Shimizu, Kôji Kubota, Tsuyoshi Notake, Hitoshi Masuo et al. · 2023 · Pathology
40. How Can Machine Perfusion Change the Paradigm of Liver Transplantation for Patients with Perihilar Cholangiocarcinoma?
    Damiano Patrono, Fabio Colli, Matteo Colangelo, Nicola De Stefano, Ana Lavinia Apostu, Elena Mazza, Silvia Catalano, Giorgia Rizza, Stefano Mirabella, Renato Romagnoli · 2023 · Journal of Clinical Medicine
41. Cost-utility analysis of Pembrolizumab compared to other alternative immunotherapy and chemotherapy treatments for patients with advanced melanoma in Iran
    Negin Bashari, Majid Safaei Lari, Ali Darvishi, Rajabali Daroudi · 2023 · Expert Review of Pharmacoeconomics & Outcomes Research
42. Development and validation of a clinical prediction model for the risk of distal metastasis in intrahepatic cholangiocarcinoma: a real-world study
    Caixia Fang, Chan Xu, Xiaodong Jia, Xiaoping Li, Chengliang Yin, Xiaojuan Xing, Wenle Li, Zhenyun Wang · 2024 · BMC Gastroenterology
43. Prevalence of Chronic Liver Disease in Cholangiocarcinoma: A Meta-Analysis
    Ethan Kai Jun Tham, Ryan Yanzhe Lim, Benjamin Koh, Darren Jun Hao Tan, Cheng Han Ng, Michelle Law, Elina En Li Cho, Nicole Shu Ying Tang, Claire Shiying Tan, Benedix Sim et al. · 2024 · Clinical Gastroenterology and Hepatology
44. Rising Mortality of Intrahepatic Cholangiocarcinoma Among Older Adults in the United States: An Analysis of Demographic and Regional Trends
    Muhammad Ali Tariq, Minhail Khalid Malik, Madiha Khan, Zunaira Ahsan Majoka, Aeman Asrar · 2024 · Liver International
45. Development and validation of web-based nomograms for predicting survival status in patients with intrahepatic cholangiocarcinoma depending on the surgical status: a SEER database analysis
    Yao-Ge Liu, Shitao Jiang, Junwei Zhang, Lei Zhang, Haitao Zhao, Xinting Sang, Xin Lü, Yiyao Xu · 2024 · Scientific Reports
46. Recent progress in emerging molecular targeted therapies for intrahepatic cholangiocarcinoma.
    Younghoon Kim, Jae-Min Song, Namkyoung Kim, Taebo Sim · 2025 · RSC Medicinal Chemistry
47. Paradigm shift of chemotherapy and systemic treatment for biliary tract cancer
    Wattana Leowattana, Tawithep Leowattana, Pathomthep Leowattana · 2023 · World Journal of Gastrointestinal Oncology
48. Intrahepatic Cholangiocarcinoma With Extrahepatic Metastasis and High Tumor Mutation Burden: Case of Complete Pathological Response to Cisplatin/Gemcitabine/Pembrolizumab
    M. Robinson, Roseanna C. Wheatley, Lucy Foster, Saurabh Jamdar, Ajith Kumar Siriwardena, Ángela Lamarca, Richard A Hubner, Juan W. Valle, Mairead Geraldine McNamara · 2024 · JCO Precision Oncology
49. Challenges in elucidating cholangiocarcinoma etiology
    Sarah S. Jackson, Andrea A. Florio, Katherine A. McGlynn, Jessica L. Petrick · 2020 · HepatoBiliary Surgery and Nutrition
50. Dynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma: A Landmarking-Based Analysis
    Gaya Spolverato, Giulia Capelli, Giulia Lorenzoni, Darío Gregori, Jin Peng He, Irinel Popescu, Hugo P. Marques, Luca Antonio Aldrighetti, Shishir Kumar Maithel, Carlo Pulitanò et al. · 2022 · Annals of Surgical Oncology
51. Identification of Prognostic Factors in Cholangiocarcinoma Based on Integrated ceRNA Network Analysis
    Haili Jin, Wei Liu, Weiming Xu, Liping Zhou, Huarong Luo, Cheng Xu, Xi Chen, Wenbin Chen · 2022 · Computational and Mathematical Methods in Medicine
52. Immune checkpoints and their promising prospect in cholangiocarcinoma treatment in combination with other therapeutic approaches
    Fatemeh Vatankhah, Neda Salimi, Amirreza Khalaji, Behzad Baradaran · 2022 · International Immunopharmacology
53. Effects of Nichi BRITE β-glucans as an onco-nutrition adjuvant in patients undergoing subtotal stomach-preserving pancreaticoduodenectomy (SSPPD) for pancreatic, bile duct and duodenal malignancies: A clinical study
    Akira Tsukada, Isao Miyajima, Satomi Uchiyama, Daiki Tabe, Nobunao Ikewaki, Koji Ichiyama, Rajappa Senthilkumar, Masaru Iwasaki, Samuel JK Abraham · 2025 · Nutrition
54. Research landscape of photodynamic therapy for hepatocellular carcinoma: Hotspots and Prospects from 2012 to 2025
    Fei Yu, Sihan Yin, Jiayu Zhu, Kewei Sun · 2025 · Hereditas
55. Evolving precision: Updates in targeted therapy for cholangiocarcinoma
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56. Survival Benefit of Surgical Treatment for Elderly Patients with Intrahepatic Cholangiocarcinoma: A Retrospective Cohort Study in the SEER Database by Propensity Score Matching Analysis
    Kaiyu Chen, Haitao Yu, Jinhuan Yang, Zhiyuan Bo, Jin Chen, Lijun Wu, Yi Wang, Gang Chen · 2023 · Current Oncology
57. Clinical outcomes for previously treated patients with advanced biliary tract cancer: a meta-analysis
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58. Comparison of efficacy and safety of conventional transarterial chemoembolization and drug-eluting bead transarterial chemoembolization in unresectable intrahepatic cholangiocarcinoma: A multicenter retrospective cohort study
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59. Sex/Gender Differences in Pancreatic and Biliary Diseases
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60. Cholangiocarcinoma in Latin America: a multicentre observational study alerts on ethnic disparities in tumour presentation and outcomes
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61. Comparison of lenvatinib plus pembrolizumab versus first-line systemic chemotherapy for advanced intrahepatic cholangiocarcinoma: a real-world retrospective study
    Zhenyun Yang, Weijie Wu, Zhiwen Hu, Yizhen Fu, Zili Hu, Yangxun Pan, Juncheng Wang, Jinbin Chen, Zhongguo Zhou, Yao‐Jun Zhang et al. · 2024 · Frontiers in Immunology
62. Trends and Disparities in Intrahepatic Cholangiocarcinoma-related Mortality in the United States from 1999 to 2020
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63. Developing models of cholangiocarcinoma to close the translational gap in cancer research
    Scott H. Waddell, Luke Boulter · 2021 · Expert Opinion on Investigational Drugs
64. Biliary tract cancers have distinct epidemiological patterns and clinical characteristics according to tumour site
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65. Novel insights into the intraepithelial spread of extrahepatic cholangiocarcinoma: clinicopathological study of 382 cases on extrahepatic cholangiocarcinoma
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66. The Human Placental Amniotic Membrane Mesenchymal-Stromal-Cell-Derived Conditioned Medium Inhibits Growth and Promotes Apoptosis of Human Cholangiocarcinoma Cells In Vitro and In Vivo by Suppressing IL-6/JAK2/STAT3 Signaling
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67. Primary Liver Cancer Trends Worldwide and in China: Analysis of GLOBOCAN 2022 Data and Disease Management Implications
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68. Intrahepatic Cholangiocarcinoma: Epidemiological Trends, Risk Factors, Diagnostic Challenges, and Advances in Personalized Therapy—A Comprehensive Review
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69. Cholangiocarcinoma in Pacific Islanders Compared to Asians.
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70. Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis
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71. Prognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma
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72. Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study
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73. Molecular and Histological Profiles and Relevant Imaging Signatures of Intrahepatic Cholangiocarcinoma
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74. Exploring the Epidemiologic Burden, Pathogenetic Features, and Clinical Outcomes of Primary Liver Cancer in Patients with Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Scoping Review
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75. Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer
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77. Locoregional therapy combined with systemic therapy (LRT + ST) for unresectable and metastatic intrahepatic cholangiocarcinoma: a systematic review and meta-analysis
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78. Efficacy and safety of S-1 following gemcitabine with cisplatin for advanced biliary tract cancer
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79. Artificial intelligence in liver cancer surgery: Predicting success before the first incision
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80. CLDN18.2: a potential nanotherapeutic target for cholangiocarcinoma
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81. Predicting perineural invasion of intrahepatic cholangiocarcinoma based on CT: a multicenter study
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86. Recent advances in molecular classification and multimodal treatment of intrahepatic cholangiocarcinoma
    Fazal Saboor, J J Lu · 2026 · World Journal of Surgical Oncology
87. Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma
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88. Liver transplantation in unresectable intrahepatic cholangiocarcinoma following neoadjuvant chemotherapy and SIRT
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89. Intrahepatic Mass-Forming Cholangiocarcinoma: Is There Additional Prognostic Value in Using Gd-EOB Enhanced MRI?
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90. Molecular biological role of epithelial splicing regulatory protein 1 in intrahepatic cholangiocarcinoma
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91. Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China
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92. Impact of genetic alterations on long-term outcomes in resectable intrahepatic cholangiocarcinoma: meta-analysis
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93. CHOLANGIOCARCINOMA: EPIDEMIOLOGY, HISTOPATHOLOGY, AND POTENTIAL PROGNOSTIC AND THERAPEUTIC IMPLICATIONS IN A COHORT FROM A REFERENCE CENTER IN SOUTHERN BRAZIL
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94. Impact of Resection Margin Status on Recurrence and Possible Candidates for Adjuvant Radiotherapy in Resected Distal Cholangiocarcinoma
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95. Efficacy and safety outcomes of PD-1/PD-L1 inhibitors in recurrent cholangiocarcinoma: a real-world, multicenter and retrospective study
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96. Cholangiocyte derived carcinomas and local microbiota
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97. Clinical Epidemiology of Cholangiocarcinoma
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98. Loss of FBP1 by aPKC-ι/Snail Pathway-Mediated Repression Promotes Invasion and Aerobic Glycolysis of Intrahepatic Cholangiocarcinoma
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99. Advances in pharmacotherapy for cholangiocarcinoma: from conventional therapies to targeted drugs
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100. ROBO1 p.E280* Loses the Inhibitory Effects on the Proliferation and Angiogenesis of Wild-Type ROBO1 in Cholangiocarcinoma by Interrupting SLIT2 Signal
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