Language‐related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds
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Multiple studies, involving distinct clinical populations, implicate contactin associated protein‐like 2 (CNTNAP2) in aspects of language development and performance. While CNTNAP2 is broadly distributed in developing rodent brain, it shows a striking gradient of frontal cortical enrichment in developing human brain, consistent with a role in patterning circuits that subserve higher cognition and language. To test the hypothesis that CNTNAP2 may be important for learned vocal communication in additional species, we employed in situ hybridization to characterize transcript distribution in the zebra finch, an experimentally tractable songbird for which the neural substrate of this behavior is well established. Consistent with an important role in learned vocalization, Cntnap2 was enriched or diminished in key song control nuclei relative to adjacent brain tissue. Importantly, this punctuated expression was observed in males, but not females, in accord with the sexual dimorphism of neural circuitry and vocal learning in this species. Ongoing functional work will provide important insights into the relationship between Cntnap2 and vocal communication in songbirds and thereby clarify mechanisms at play in disorders of human cognition and language. J. Comp. Neurol. 518:1995–2018, 2010. © 2010 Wiley‐Liss, Inc.
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In animal models, the candidate autism genes Chd8 and Cntnap2 show sex-differentiated expression.
“In studies in animal models, the candidate autism genes Chd8 (ref.250) and Cntnap2 (ref.251) show sex-differentiated expression.”
From Sex and gender in neurodevelopmental conditions (2023) · cites this paper as [251]
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- Authors
- Panaitof, S. C., Abrahams, B. S., Dong, H., Geschwind, D. H., & White, S. A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- White, Stephanie A.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2010-04-06
- Volume
- 518
- Issue
- 11
- Pages
- 1995-2018
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC2864722
- OpenAlex
- W2011274347
- Cited by
- 49
- References
- 97
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH64547, R01MH070712, U54MH68172, U54MH068172, R01MH064547)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21 HD06527, R21HD065271, P50HD055784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- CNTNAP2, song control nuclei, zebra finch, vocal learning, sexual dimorphism, gene expression, songbirds, language development, neural circuits
- MeSH terms
- Animals, Brain, Female, Gene Expression Regulation, Humans, Learning, Male, Membrane Proteins, Nerve Net, Nerve Tissue Proteins, Sex Characteristics, Tissue Distribution, Vocalization, Animal, In Situ Hybridization, Songbirds
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