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Cited by 24Neurogenesis and neuroplasticity mechanismsBarrier Structure and Function StudiesNerve injury and regeneration

Novel insights into the glia limitans of the olfactory nervous system

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Nazareth, Lynn, Chen, Mo, Shelper, Todd, Shah, Megha, Tello Velasquez, Johana, Walkden, Heidi, Beacham, Ifor, Batzloff, Michael +5 more·2019·Journal of Comparative Neurology
DOI 10.1002/cne.24618
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Abstract

Olfactory ensheathing cells (OECs) are often described as being present in both the peripheral and the central nervous systems (PNS and CNS). Furthermore, the olfactory nervous system glia limitans (the glial layer defining the PNS–CNS border) is considered unique as it consists of intermingling OECs and astrocytes. In contrast, the glia limitans of the rest of the nervous system consists solely of astrocytes which create a distinct barrier to Schwann cells (peripheral glia). The ability of OECs to interact with astrocytes is one reason why OECs are believed to be superior to Schwann cells for transplantation therapies to treat CNS injuries. We have used transgenic reporter mice in which glial cells express DsRed fluorescent protein to study the cellular constituents of the glia limitans. We found that the glia limitans layer of the olfactory nervous system is morphologically similar to elsewhere in the nervous system, with a similar low degree of intermingling between peripheral glia and astrocytes. We found that the astrocytic layer of the olfactory bulb is a distinct barrier to bacterial infection, suggesting that this layer constitutes the PNS–CNS immunological barrier. We also found that OECs interact with astrocytes in a similar fashion as Schwann cells in vitro. When cultured in three dimensions, however, there were subtle differences between OECs and Schwann cells in their interactions with astrocytes. We therefore suggest that glial fibrillary acidic protein–reactive astrocyte layer of the olfactory bulb constitutes the glia limitans of the olfactory nervous system and that OECs are primarily “PNS glia.”

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Cited by

Sorted by citations

Authors
Nazareth, L., Chen, M., Shelper, T., Shah, M., Tello Velasquez, J., Walkden, H., Beacham, I., Batzloff, M., Rayfield, A., Todorovic, M., Beagley, K. W., St John, J. A., & Ekberg, J. A. K.
Affiliations
  • Griffith University (AU)
  • Clem Jones Centre for Neurobiology and Stem Cell Research Griffith Institute for Drug Discovery, Griffith University Nathan Queensland Australia
  • Queensland University of Technology (AU)
Corresponding author
Ekberg, Jenny A. K.
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2019-01-16
Volume
527
Issue
7
Pages
1228-1244
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.24618
OpenAlex
W2906896644
Cited by
24
References
1
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 3
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc)
  • Griffith Research Online (submittedVersion)
Funders
  • Australian Research Council (DP150104495 (Project grant))
  • Griffith University (Postdoctoral Fellowship)
  • Clem Jones Foundation (Project grant)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
glia limitans, olfactory ensheathing cells, olfactory bulb, astrocytes, Schwann cells, glial fibrillary acidic protein, transgenic reporter mice, 3D cell culture
MeSH terms
Animals, Astrocytes, Cells, Cultured, Melioidosis, Mice, Inbred BALB C, Mice, Transgenic, Nasal Cavity, Neuroglia, Olfactory Bulb, Sensory Receptor Cells, Schwann Cells, Trigeminal Nerve, Burkholderia pseudomallei, Genes, Reporter, Peripheral Nervous System, Cell Culture Techniques, Mice

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