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Cited by 260Cholinesterase and Neurodegenerative DiseasesNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Transient cholinesterase staining in the mediodorsal nucleus of the thalamus and its connections in the developing human and monkey brain

Kostovic, Ivica, Goldman‐Rakic, Patricia S.·1983·Journal of Comparative Neurology
DOI 10.1002/cne.902190405
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Abstract

The histochemical and morphological maturation of the mediodorsal nucleus (MD) and its connections were compared in human and rhesus monkey using acetylthiocholine iodide and Nissl methods. Histochemical analysis in fetuses, neonates, and adults of both primate species revealed that MD passes through three major stages of cholinesterase (ChE) reactivity. In Stage I (up to about 16 fetal weeks in man; 9 fetal weeks in monkey), ChE staining gradually increases in the MD nucleus and is intense in axons directed toward the frontal lobe through the internal and external capsules. In Stage II (about 16‐28 fetal weeks in man; about 9‐14 weeks in monkey), ChE staining in MD reaches peak intensity so that reaction product in the neurons and neuropil blackens the entire nucleus in both species. In favorable planes of section, ChE‐positive fibers appear to connect MD and the basal forebrain both of which stain intensely. ChE‐positive fibers can also be traced from the lateral margins of MD to the subplate zone beneath the developing frontal cortical plate where they continue to accumulate before later invading the cortex with heaviest concentration in presumptive layers 3 and 5. In Stage III (after 28 weeks of gestation to 6 postnatal months in man; from about 14 fetal weeks until 2 postnatal months in monkey), except for scattered positive cells, ChE staining gradually disappears in MD and the formerly dense laminar pattern in the cortex begins to lighten. The dramatic but transient increase in ChE staining in MD during fetal development as well as the sequentially related changes in its projections indicate that this early appearing enzyme may play a role in the development of the frontal lobe by influencing the differentiation of thalamoprefrontal connections.

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Research works printed but not linked: 14

  1. Candy J. M., 1981, Distribution of putative cholinergic cell bodies and various neuropoptiades in the substantia innominata region of the human brain, J. Anat., 133, 123
  2. Dekker J. S., 1980, Genesis of the motor cortex and VA‐VL thalamic complex in rhesus monkey, Abstr. Soc. Neurol., 6, 205
  3. Drews U., 1975, Cholinesterase in Embryonic Development. Progress in Histochemistry. Vol. 7, No. 3
  4. Giacobini G., 1973, Studies on Metabolic Regulation and Function, 153
  5. Joo F., 1963, Ontogenetic differentiation of cholinesterase‐active structures in archicerebellar cortex, Folia Histochem. Cytochem. [Suppl.], 1, 118
  6. Kostovic I., 1979, Columnar distribution of acetylcholinesterase staining; in the frontal cortex of the human fetus, Neurosci. Lett. [Suppl.], 3, 22
  7. Kostovic‐Knezevic L., 1979, Acetylcholinesterase (AChE) staining in the growing telencephalic structures of the human fetus, Verh. Anat. Ges., 73, 667
  8. Mufson E. Y., 1982, Cholinergic projections from the mesencephalic tegmentum to neocortex in rhesus monkey, Soc. Neurosci. Abstr., 8, 135
  9. Olivier G., 1961, Horizons de Streeter et age embryonnaire. Bull. Assoc. Anat. (Nancy), C. R. Assoc. Anat., 47, 573
  10. Rakic P., 1976, The Pulvinar‐LP Complex, 3
  11. Struble R. C., 1982, Ibotenic acid lesions of the primate nucleus basalis of Meynert result in decreased cortical choline acetylcholinesterase, Neurosci. Abstr., 8, 217
  12. Velayos J. L., 1982, Topographical organization of the prosencephalic afferents to the mediodorsal thalamic nucleus, Neurosci Lett. [Suppl.], 10, S502
  13. Yakovlev P. I., 1967, Modern Neurology, Papers in Tribute to Professor Derek Denny‐Brown, 3
  14. Yakovlev P. I., 1969, Modern Neurology, Paper in Tribute to Derek Denny‐Brown, 15

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Metadata

Authors
Kostovic, I., & Goldman‐Rakic, P. S.
Affiliations
Yale University (US)
Corresponding author
Goldman‐Rakic, Patricia S.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1983-10
Volume
219
Issue
4
Pages
431-447
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902190405
OpenAlex
W2012514021
Cited by
260
References
49
Citations by year
2025: 2 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 10 · 2013: 7 · 2012: 7
FWCI
3.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7679 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
mediodorsal nucleus, thalamus, cholinesterase, acetylthiocholine iodide, frontal lobe development, fetal brain development, rhesus monkeys, human brain, subplate, developmental maturation
MeSH terms
Animals, Cholinesterases, Histocytochemistry, Humans, Macaca, Macaca mulatta, Neural Pathways, Staining and Labeling, Thalamic Nuclei, Tissue Distribution

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