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Cited by 395Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase

Gaspar, Patricia, Berger, Brigitte, Febvret, Aude, Vigny, Annette, Henry, Jean Pierre·1989·Journal of Comparative Neurology
DOI 10.1002/cne.902790208
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Abstract

The organization of the cortical monoamine systems, dopamine (DA), and noradrenaline (NA), which have been studied extensively in the rat and more recently in the monkey, had not yet been investigated directly in the human brain. We report here the first systematic account of the regional and laminar distributions of the catecholamine fibers in the human cerebral cortex, using immunohistochemistry of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH), and dopamine‐β‐hydroxylase (DBH) in 13 cytoarchitectonic areas (4, 6, 9, 3b, 5, 40, 17, 18, 23, 24, 29, insula, and hippocampus) sampled postmortem. The noradrenergic (NA) innervation, mapped with DBH‐immunoreactivity (DBH‐IR), displayed a characteristic density gradient in the neocortex (highest in the primary sensorimotor areas, decreasing rostrally and caudally) that contrasted with the more uniform density in the limbic cortices (24, 23, 29, insula, hippocampus). NA axons were present in all cortical layers and were least numerous in layer I. The DBH‐IR fibers were only partly TH‐immunostained (10–50%, on double‐labeled sections), suggesting a heterogeneity of the cortical NA axons. The putative dopaminergic (DA) fibers were identified by comparing alternate or double‐immunolabeled (DBH‐TH) sections, as the TH‐IR fibers which contain no DBH‐IR. A DA‐like innervation was present in all cortical areas, with major regional differences in density and laminar distribution, which closely paralleled cytoarchitectural buildups: (1) the DA‐like innervation was densest in the agranular areas, primary and secondary motor areas, anterior cingulate, and insula; it distributed throughout layers I–VI; (2) density was lower in the granular cortices, areas 9 (prefrontal cortex), 23, 3b, 5, 40, and 18, displaying a bilaminar pattern in layers I and V–VI. In all areas, DA‐like fibers were most abundant in the molecular layer, with a predominant distribution in its deepest part. Convoluted and coily fibers represented a unique morphologic aspect of the CA innervation in the human cortex. These findings are in agreement with findings in nonhuman primates and demonstrate major evolutionary changes in the organization of the cortical aminergic input as compared with rodents. The most striking features are the expansion of the DA innervation to the whole cortex and the peak of highest density in the motor areas. The regional differentiation of NA innervation is also accentuated. Slight differences were found in the laminar distributions of the amines in humans and primates. These data seem quite promising and open new research fields in neurologic and psychiatric diseases.

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Research works printed but not linked: 12

  1. Berger B., 1976, Axones catecholaminergiques du cortex cérébral humain. Observation, en histofluorscence, de biopsiescérébrales dont 2 cas de maladie d'Alzheimer, Rev. Neurol., 132, 183
  2. Berger B., 1980, Enzymes and Neurotransmitters in Mental Disease, 317
  3. Berger B., 1986, Differential distribution of dopamine and serotonin axons in monkey cerebral cortex. A radioautographic study, Neurosci. Lett. Suppl., 26, S105
  4. Burke W. J., 1987, Geriatrics Clinical Pharmacology, 47
  5. Hökfelt T., 1977, Immunohistochemical studies on the localization and distribution of monoamine neuron systems in the rat. IITyrosine‐hydroxylase in the telencephalon, Med. Bio., 55, 21
  6. Hökfelt T., 1984, Handbook of Chemical Neuroanatomy, 277
  7. Javoy‐Agid F., 1987, Distribution of monoaminergic, cholinergic and peptidergic markers in the human cerebral cortex, Soc. Neurosci. Abstr., 13, 527
  8. Kitt C. A., 1984, Contribution of catecholaminergic systems to neurites in plaques of aged primates, Ann. Neurol., 16, 118
  9. Mann D. M. A., 1983, The pathology of the human locus coeruleus, Clinical Neuropathol., 2, 1
  10. Marin‐Padilla M., 1986, Cerebral Cortex, 447
  11. Sanidés F., 1964, The cyto‐myeloarchitecture of the human frontal lobe, its relation to phylogenetic differentiation of the cerebral cortex, J. für Hirnforsch., 6, 269
  12. Von Economo C. V., 1972, L'architecture cellulaire normale de l'écorce cérébrale

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Metadata

Authors
Gaspar, P., Berger, B., Febvret, A., Vigny, A., & Henry, J. P.
Affiliations
  • Inserm (FR)
  • Institut de Biologie Physico-Chimique (FR)
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1989-01-08
Volume
279
Issue
2
Pages
249-271
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902790208
OpenAlex
W2069412440
Cited by
395
References
79
Citations by year
2026: 4 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 14 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 9
FWCI
5.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5753 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
catecholamine innervation, human cerebral cortex, noradrenergic innervation, dopaminergic innervation, tyrosine hydroxylase, dopamine beta-hydroxylase, cortical laminar distribution, cytoarchitectonic areas, molecular layer, neocortex, limbic cortex, norepinephrine, postmortem brain
MeSH terms
Adult, Aged, Aged, 80 and over, Catecholamines, Cerebral Cortex, Dopamine beta-Hydroxylase, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Fibers, Tyrosine 3-Monooxygenase

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