Investigating Protein–Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

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Expanding the Genetic Code of Escherichia coli

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Using chemical shift perturbation to characterise ligand binding

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Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

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NMR Spectroscopy Techniques for Screening and Identifying Ligand Binding to Protein Receptors

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Attenuated T2 relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Pervushin, K. V., Riek, R., Wider, G., & Kurt Wüthrich, A. (2021) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789811235795_0006 · Cited by 951 · see citing works

The maximal affinity of ligands

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Conformational entropy in molecular recognition by proteins

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Cross-Correlated Relaxation Enhanced 1 H− 13 C NMR Spectroscopy of Methyl Groups in Very High Molecular Weight Proteins and Protein Complexes

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Methods for Measurement of Intermolecular NOEs by Multinuclear NMR Spectroscopy: Application to a Bacteriophage λ N-Peptide/boxB RNA Complex

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THE USE OF 2 H, 13 C, 15 N MULTIDIMENSIONAL NMR GTO STUDY THE STRUCTURE AND DYNAMICS OF PROTEINS

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WaterLOGSY as a method for primary NMR screening: Practical aspects and range of applicability

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Bioorthogonale Chemie – oder: in einem Meer aus Funktionalität nach Selektivität fischen

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A Solution-Phase Chemical Approach to a New Crystal Structure of Cobalt

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Order matrix analysis of residual dipolar couplings using singular value decomposition.

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Optimal isotope labelling for NMR protein structure determinations

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Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water*

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Magnetically-oriented phospholipid micelles as a tool for the study of membrane-associated molecules

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Theory and applications of the transferred nuclear overhauser effect to the study of the conformations of small ligands bound to proteins

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One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

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Quantitative NMR spectroscopy in pharmaceutical applications

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Heteronuclear filters in two-dimensional [1H, 1H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions

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Pure shift NMR

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Studies of protein hydration in aqueous solution by direct NMR observation of individual protein-bound water molecules

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A novel NMR method for determining the interfaces of large protein-protein complexes.

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Current applications of 19F NMR to studies of protein structure and dynamics

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Recent developments in transferred NOE methods

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Theory of the time dependent transferred nuclear Overhauser effect: Applications to structural analysis of ligand-protein complexes in solution

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Direct Proline‐Catalyzed Asymmetric α‐Aminoxylation of Ketones

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Copper‐Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles

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Solution NMR of Paramagnetic Molecules

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A Graphene‐Based Platform for the Assay of Duplex‐DNA Unwinding by Helicase

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NMR studies of water bound to biological molecules

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NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules

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Identification of Protein Surfaces by NMR Measurements with a Paramagnetic Gd(III) Chelate

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Virus−Ligand Interactions: Identification and Characterization of Ligand Binding by NMR Spectroscopy

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New frontiers and developing applications in 19F NMR

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An Antibody Binding Site on Cytochrome C Defined by Hydrogen Exchange and Two-Dimensional NMR

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Complete Assignment of Heteronuclear Protein Resonances by Protonless NMR Spectroscopy

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Biosynthesis of Proteins Incorporating a Versatile Set of Phenylalanine Analogues

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The INPHARMA Method: Protein‐Mediated Interligand NOEs for Pharmacophore Mapping

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Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags

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NMR‐Techniken zum Screening und zur Identifizierung der Bindung von Liganden an Proteinrezeptoren

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Applications of saturation transfer difference NMR in biological systems

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An Easy and Scalable Method for the Partial Alignment of Organic Molecules for Measuring Residual Dipolar Couplings

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Lanthanide Labeling Offers Fast NMR Approach to 3D Structure Determinations of Protein−Protein Complexes

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Quantitative Analysis of Multisite Protein–Ligand Interactions by NMR: Binding of Intrinsically Disordered p53 Transactivation Subdomains with the TAZ2 Domain of CBP

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Hydrogen exchange and protein folding

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Mapping the Orientation of Helices in Micelle-Bound Peptides by Paramagnetic Relaxation Waves

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Structural Basis for Nucleic Acid and Toxin Recognition of the Bacterial Antitoxin CcdA

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Localization of tyrosine at the binding site of neurophysin II by negative nuclear Overhouser effects

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Quantification of the Cellular Uptake of Cell‐Penetrating Peptides by MALDI‐TOF Mass Spectrometry

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Estimating Protein−Ligand Binding Affinity Using High-Throughput Screening by NMR

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Quantitative analysis of protein–ligand interactions by NMR

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Determination of the Interface of a Large Protein Complex by Transferred Cross-saturation Measurements

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1D Saturation Transfer Difference NMR Experiments on Living Cells: The DC‐SIGN/Oligomannose Interaction

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Small-Molecule Binding Sites on Proteins Established by Paramagnetic NMR Spectroscopy

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NMR Methods for the Study of Instrinsically Disordered Proteins Structure, Dynamics, and Interactions: General Overview and Practical Guidelines

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Applications of 19F-NMR in Fragment-Based Drug Discovery

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Use of Relaxation Enhancements in a Paramagnetic Environment for the Structure Determination of Proteins Using NMR Spectroscopy

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Protein interaction patterns in different cellular environments are revealed by in-cell NMR

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Residual dipolar coupling derived orientational constraints on ligand geometry in a 53 kDa protein-ligand complex

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Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR)

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Structural Analysis of Large Protein Complexes Using Solvent Paramagnetic Relaxation Enhancements

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Novel methods based on 13C detection to study intrinsically disordered proteins

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Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR

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Reliable high-throughput functional screening with 3-FABS

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Recent progress in NMR spectroscopy: Toward the study of intrinsically disordered proteins of increasing size and complexity

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Kupferkatalysierte Azid‐Alkin‐Cycloadditionen: regioselektive Synthese von 1,4,5‐trisubstituierten 1,2,3‐Triazolen

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Studying the Structure and Dynamics of Biomolecules by Using Soluble Paramagnetic Probes

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SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly

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Effects of paramagnetic lanthanide shift reagents on the proton magnetic resonance spectra of quinoline and pyridine

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A Graphene‐Based Platform for the Assay of Duplex‐DNA Unwinding by Helicase

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An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe

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Measurement of dipolar couplings in a transducin peptide fragment weakly bound to oriented photo-activated rhodopsin

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Positioning of Micelle-Bound Peptides by Paramagnetic Relaxation Enhancements

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Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

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Eine einfache und skalierbare Methode für die partielle Orientierung organischer Moleküle zur Messung dipolarer Restkopplungen (RDCs)

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NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

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Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins

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The INPHARMA Method: Protein‐Mediated Interligand NOEs for Pharmacophore Mapping

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Enhancing the resolution of multi-dimensional heteronuclear NMR spectra of intrinsically disordered proteins by homonuclear broadband decoupling

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NMR in natural products: understanding conformation, configuration and receptor interactions

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Complete Assignment of Heteronuclear Protein Resonances by Protonless NMR Spectroscopy

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Identification of a protein-binding surface by differential amide hydrogen-exchange measurements

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Hydrogen exchange and ligand binding: Ligand‐dependent and ligand‐independent protection in the Src SH3 domain

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Structural and Functional Implications of the Interaction between Macrolide Antibiotics and Bile Acids

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Detection of intermolecular NOE interactions in large protein complexes

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1D Saturation Transfer Difference NMR Experiments on Living Cells: The DC‐SIGN/Oligomannose Interaction

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Probing the Interactions of Macrolide Antibiotics with Membrane-Mimetics by NMR Spectroscopy

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Lectin‐Based Drug Design: Combined Strategy to Identify Lead Compounds using STD NMR Spectroscopy, Solid‐Phase Assays and Cell Binding for a Plant Toxin Model

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Visualizing an Ultra‐Weak Protein–Protein Interaction in Phosphorylation Signaling

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