The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oxygen Uptake Kinetics
Abstract
Muscular exercise requires transitions to and from metabolic rates often exceeding an order of magnitude above resting and places prodigious demands on the oxidative machinery and O 2‐transport pathway. The science of kinetics seeks to characterize the dynamic profiles of the respiratory, cardiovascular, and muscular systems and their integration to resolve the essential control mechanisms of muscle energetics and oxidative function: a goal not feasible using the steady‐state response. Essential features of the O 2 uptake (o2) kinetics response are highly conserved across the animal kingdom. For a given metabolic demand, fasto2 kinetics mandates a smaller O 2 deficit, less substrate‐level phosphorylation and high exercise tolerance. By the same token, slowo2 kinetics incurs a high O 2 deficit, presents a greater challenge to homeostasis and presages poor exercise tolerance. Compelling evidence supports that, in healthy individuals walking, running, or cycling upright,o2 kinetics control resides within the exercising muscle(s) and is therefore not dependent upon, or limited by, upstream O 2‐transport systems. However, disease, aging, and other imposed constraints may redistributeo2 kinetics control more proximally within the O 2‐transport system. Greater understanding ofo2 kinetics control and, in particular, its relation to the plasticity of the O 2‐transport/utilization system is considered important for improving the human condition, not just in athletic populations, but crucially for patients suffering from pathologically slowedo2 kinetics as well as the burgeoning elderly population. © 2012 American Physiological Society.Compr Physiol 2:933‐996, 2012.
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Measurement of the maximum oxygen uptake V̇ o 2max : V̇ o 2peak is no longer acceptable
Poole, D. C., & Jones, A. M. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01063.2016 · Cited by 533
Self-citationGrassi, B., & Quaresima, V. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.9.091313 · Cited by 345
Taylor, N. A. S. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130022 · Cited by 331
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Metadata
- Authors
- Poole, D. C., & Jones, A. M.
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2012-04
- Volume
- 2
- Issue
- 2
- Pages
- 933-996
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W1899906888
- Cited by
- 514
- References
- 19
- Type
- other
- Language
- en
- Open access
- closed
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