Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Human Insulin Receptor Substrate-1 (IRS-1) Polymorphism G972R Causes IRS-1 to Associate with the Insulin Receptor and Inhibit Receptor Autophosphorylation

McGettrick, A., Feener, E. P., & Kahn, C. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412300200 · Cited by 78

Leg free fatty acid kinetics during exercise in men and women

Burguera, B., Proctor, D., Dietz, N., Guo, Z., Joyner, M., & Jensen, M. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.1.e113 · Cited by 77

C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo

Devaraj, S., Dasu, M. R. K., Singh, U. S., Rao, L. V. M., & Jialal, I. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.060 · Cited by 77

Reversibility of Chronic Experimental Syndrome X by Diet Modification

Roberts, C. K., Vaziri, N. D., Liang, K. H., & Barnard, R. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1323 · Cited by 77

GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

Brozinick, J. T., McCoid, S. C., Reynolds, T., Nardone, N. A., Hargrove, D. M., Stevenson, R. W., Cushman, S. W., & Gibbs, E. M. (2001) · Diabetes · doi:10.2337/diabetes.50.3.593 · Cited by 76

Fasting increases plasma membrane fatty acid-binding protein (FABPPM) in red skeletal muscle

Turcotte, L. P., Srivastava, A. K., & Chiasson, J. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006846907394 · Cited by 75

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

Lacraz, G., Giroix, M.-H., Kassis, N., Coulaud, J., Galinier, A., Noll, C., Cornut, M., Schmidlin, F., Paul, J., Janel, N., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006963 · Cited by 74

Cardiorespiratory Fitness as a Feature of Metabolic Syndrome in Older Men and Women

Hassinen, M., Lakka, T. A., Savonen, K. P., Litmanen, H., Kiviaho, L., Laaksonen, D. E., Komulainen, P., & Rauramaa, R. (2008) · Diabetes Care · doi:10.2337/dc07-2298 · Cited by 74

Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity

Sasaoka, T., Wada, T., & Tsuneki, H. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.06.001 · Cited by 73

Cardiorespiratory Fitness, Macronutrient Intake, and the Metabolic Syndrome: The Aerobics Center Longitudinal Study

Finley, C. E., LaMonte, M. J., Waslien, C., Barlow, C. E., Blair, S. N., & Nichaman, M. Z. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.02.012 · Cited by 73

Effects of a high-fat, sucrose diet on serum insulin and related atherosclerotic risk factors in rats

Barnard, R. J., Faria, D. J., Menges, J. E., & Martin, D. A. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90209-d · Cited by 73

Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle

Steinberg, G. R., Smith, A. C., Wormald, S., Malenfant, P., Collier, C., & Dyck, D. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2003 · Cited by 73

Effects of HRT and exercise training on insulin action, glucose tolerance, and body composition in older women

Evans, E. M., Pelt, R. E. V., Binder, E. F., Williams, D. B., Ehsani, A. A., & Kohrt, W. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2033 · Cited by 73

Leisure time physical activity in middle age predicts the metabolic syndrome in old age: results of a 28-year follow-up of men in the Oslo study

Holme, I., Tonstad, S., Søgaard, A. J., Larsen, P. G. L., & Håheim, L. L. (2007) · BMC Public Health · doi:10.1186/1471-2458-7-154 · Cited by 72

Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5

Watson, R. T., & Pessin, J. E. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.1.c215 · Cited by 72

Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance

Han, D.-H., Hancock, C. R., Jung, S. R., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019739 · Cited by 71

Leisure-Time Physical Activity is Associated with a Reduced Risk for Metabolic Syndrome

Cho, E. R., Shin, A., Kim, J., Jee, S. H., & Sung, J. (2009) · Annals of Epidemiology · doi:10.1016/j.annepidem.2009.06.010 · Cited by 71

Point: The Metabolic Syndrome Still Lives

Grundy, S. M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.050989 · Cited by 71

92195928 Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal women

Haffner, S. M., Katz, M., & Dunn, J. F. (1992) · Maturitas · doi:10.1016/0378-5122(92)90239-z · Cited by 70

Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers

Vistisen, B., Roepstorff, K., Roepstorff, C., Bonen, A., van Deurs, B., & Kiens, B. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300424-jlr200 · Cited by 70

Exercise Decreases the Risk of Metabolic Syndrome in Elderly Females

KEMMLER, W. K., von Stengel, S., Engelke, K., & Kalender, W. A. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818844b7 · Cited by 68

Strength and endurance training lead to different post exercise glucose profiles in diabetic participants using a continuous subcutaneous glucose monitoring system

Cauza, E., Hanusch‐Enserer, U., Strasser, B., Kostner, K., Dunky, A., & Haber, P. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01573.x · Cited by 67

C-Reactive Protein Suppresses Insulin Signaling in Endothelial Cells: Role of Spleen Tyrosine Kinase

Xu, J., Morita, I., Ikeda, K., Miki, T., & Yamori, Y. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0354 · Cited by 67

Biochemical Determination of Training Effects Using Insulin Clamp Technique

Sato, Y., Iguchi, A., & Sakamoto, N. (1984) · Hormone and Metabolic Research · doi:10.1055/s-2007-1014825 · Cited by 66

Lipotoxicity: the obese and endurance-trained paradox

Russell, A. P. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802859 · Cited by 66

When will we treat physical activity as a legitimate medical therapy…even though it does not come in a pill?

Church, T. S., & Blair, S. N. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.053850 · Cited by 66

Aerobic Exercise Increases Peripheral and Hepatic Insulin Sensitivity in Sedentary Adolescents

van der Heijden, G., TOFFOLO, G. M., Manesso, E., Sauer, P. J. J., & Sunehag, A. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1379 · Cited by 65

Exercise and the metabolic syndrome with weight regain

Thomas, T. R., Warner, S. O., Dellsperger, K. C., Hinton, P. S., Whaley‐Connell, A. T., Rector, R. S., Liu, Y., Linden, M. A., Chockalingam, A., Thyfault, J. P., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01361.2009 · Cited by 65

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport

Yu, M., Blomstrand, E., Chibalin, A., Wallberg‐Henriksson, H., Zierath, J. R., & Krook, A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.1.29 · Cited by 64

Heat Shock Protein 72 Response to Exercise in Humans

Yamada, P. M., Amorim, F. T., Moseley, P. L., & Schneider, S. M. (2008) · Sports Medicine · doi:10.2165/00007256-200838090-00002 · Cited by 64

Pancreatic β-Cell Damage Mediated by β-Cell Production of Interleukin-1

Heitmeier, M. R., Arnush, M., Scarim, A. L., & Corbett, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009159200 · Cited by 64

Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese population

Ishihara, H., Sasaoka, T., Kagawa, S., Murakami, S., Fukui, K., Kawagishi, Y., Yamazaki, K., Sato, A., Iwata, M., Urakaze, M., et al. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01225-0 · Cited by 63

Impact of Transgenic Overexpression of SH2-Containing Inositol 5′-Phosphatase 2 on Glucose Metabolism and Insulin Signaling in Mice

Kagawa, S., Soeda, Y., Ishihara, H., Oya, T., Sasahara, M., Yaguchi, S., Oshita, R., Wada, T., Tsuneki, H., & Sasaoka, T. (2007) · Endocrinology · doi:10.1210/en.2007-0820 · Cited by 63

Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARγ agonists

Soo, B., Ciaraldi, T. P., Park, K. S., Carter, L., Mudaliar, S. R. D., & Henry, R. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00141.2004 · Cited by 62

Effects of Intense Exercise and Moderate Caloric Restriction on Cardiovascular Risk Factors and Inflammation

Ahmadi, N., Eshaghian, S., Huizenga, R., Sosnin, K., Ebrahimi, R., & Siegel, R. J. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.02.032 · Cited by 61

Insulin resistance and metabolic syndrome in chronic liver diseases: Old entities with new implications

Tsochatzis, E. A., Manolakopoulos, S., Papatheodoridis, G., & Archimandritis, A. J. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802273058 · Cited by 60

Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?

Geering, B., Cutillas, P. R., & Vanhaesebroeck, B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350199 · Cited by 60

Signal transduction pathway of acylation stimulating protein: involvement of protein kinase C

Baldo, A., Sniderman, A. D., Luce, S. S., Zhang, X. J., & Cianflone, K. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39728-5 · Cited by 60

Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat

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Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice

Murray, I. V. J., Sniderman, A. D., & Cianflone, K. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.3.e474 · Cited by 60

Depot-Specific Variation in Protein-Tyrosine Phosphatase Activities in Human Omental and Subcutaneous Adipose Tissue: A Potential Contribution to Differential Insulin Sensitivity

Wu, X., Hoffstedt, J., Deeb, W., Singh, R., Sedkova, N., Zilbering, A., Zhu, L., Park, P. K., Arner, P., & Goldstein, B. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8109 · Cited by 59

Physical activity and risk of Metabolic Syndrome in an urban Mexican cohort

Méndez‐Hernández, P., Flóres, Y. N., Siani, C., Lamure, M. P., Dosamantes-Carrasco, L. D., Halley-Castillo, E., Huitrón, G., Talavera, J. O., Gallegos-Carrillo, K., & Salmerón, J. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-276 · Cited by 59

Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes

Barwell, N. D., Malkova, D., Moran, C. N., Cleland, S. J., Packard, C. J., Zammit, V. A., & Gill, J. M. R. (2008) · Diabetologia · doi:10.1007/s00125-008-1097-6 · Cited by 58

Effects of Training and Training Cessation on Insulin Action

Oshida, Y., Yamanouchi, K., Hayamizu, S., Nagasawa, J., Ohsawa, I., & Sato, Y. (1991) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024718 · Cited by 57

Exercise and Diet in the Prevention and Control of the Metabolic Syndrome

Barnard, R. J., & Wen, S. J. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00002 · Cited by 57

Prevalence of the Metabolic Syndrome Among Obese Adolescents Enrolled in a Multidisciplinary Weight Management Program: Clinical Correlates and Response to Treatment

Wickham, E. P., Stern, M., Evans, R. K., Bryan, D. L., Moskowitz, W. B., Clore, J. N., & Laver, J. H. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0038 · Cited by 57

Effects of training and detraining on dose-response relationship between glucose and insulin secretion

Mikines, K. J., Sonne, B., Tronier, B., & Galbo, H. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.5.e588 · Cited by 57

Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-α Expression

Yuen, D. Y. C., Dwyer, R. M., Matthews, V. B., Zhang, L., Drew, B. G., Neill, B., Kingwell, B. A., Clark, M. G., Rattigan, S., & Febbraio, M. A. (2009) · Diabetes · doi:10.2337/db08-0775 · Cited by 55

Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance

Holloway, G. P., Chou, C. J., Lally, J., Stellingwerff, T., Maher, A. C., Gavrilova, O., Haluzik, M., Alkhateeb, H., Reitman, M. L., & Bonen, A. (2011) · Diabetologia · doi:10.1007/s00125-011-2114-8 · Cited by 54

Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat‐fed, streptozotocin‐treated diabetic rats

Wu, Y., Ouyang, J. P., Wu, K., Wang, S. S., Wen, C.-Y., & Xia, Z. Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706306 · Cited by 54

Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects

Polak, J., Moro, C., Klimčáková, E., Hejnová, J., Majercik, M., Viguerie, N., Langin, D., Lafontan, M., Štich, V., & Berlan, M. (2005) · Diabetologia · doi:10.1007/s00125-005-0003-8 · Cited by 54

Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training

YOUNGREN, J. F., Keen, S., Kulp, J. L., Tanner, C. J., Houmard, J. A., & Goldfine, I. D. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.3.e528 · Cited by 54

Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle

Wadley, G. D., Tunstall, R. J., Sanigorski, A., Collier, G. R., Hargreaves, M., & Cameron‐Smith, D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.436 · Cited by 53

Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes

Takala, T., Nuutila, P., Knuuti, J. M., Luotolahti, M., & Yki‐Järvinen, H. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e706 · Cited by 53

Monocyte Chemoattractant Protein-1 Deficiency Protects Against Visceral Fat-Induced Atherosclerosis

Öhman, M. K., Wright, A. P., Wickenheiser, K. J., Luo, W., Russo, H. M., & Eitzman, D. T. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.205914 · Cited by 52

Training cessation does not alter GLUT-4 protein levels in human skeletal muscle

Houmard, J. A., Hortobágyi, T., Neufer, P. D., Johns, R. A., Fraser, D. D., Israel, R. G., & Dohm, G. L. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.2.776 · Cited by 51

Identification of Stat 5B as a Substrate of the Insulin Receptor

Sawka‐Verhelle, D., Filloux, C., Tartare‐Deckert, S., Mothe‐Satney, I., & OBBERGHEN, E. V. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.0411a.x · Cited by 51

Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats

YOUNGREN, J. F., Paik, J., & Barnard, R. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2240 · Cited by 51

C-Reactive Protein Stimulates Myeloperoxidase Release from Polymorphonuclear Cells and Monocytes: Implications for Acute Coronary Syndromes

Singh, U. S., Devaraj, S., & Jialal, I. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.109207 · Cited by 50

Effect of Exercise Training Modality on C-Reactive Protein in Type 2 Diabetes

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Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3

Shisheva, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90353.2008 · Cited by 49

Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet

Morris, M. J., Chen, H., Watts, R. P., Shulkes, A., & Cameron‐Smith, D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803716 · Cited by 48

A 7-d Exercise Program Increases High–Molecular Weight Adiponectin in Obese Adults

Kelly, K. R., Blaszczak, A. M., Haus, J. M., Patrick-Melin, A. J., Fealy, C. E., Solomon, T. P. J., KALINSKI, M. I., & Kirwan, J. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318228bf85 · Cited by 48

Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with ‘exercise mimetics’

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Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion

Carey, A. L., Petersen, E. W., Bruce, C. R., Southgate, R. J., Pilegaard, H., Hawley, J. A., Pedersen, B. K., & Febbraio, M. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0178-7 · Cited by 47

Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng

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Neutrophil-Activating Peptide ENA-78

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Glucose Tolerance and Insulin Response to Glucose Load in Body Builders*

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6 Insulin sensitivity in the intact organism

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Short-Termin VivoInhibition of Insulin Receptor Substrate-1 Expression Leads to Insulin Resistance, Hyperinsulinemia, and Increased Adiposity

ARAUJO, E. P. D., de Souza, C. T., Gasparetti, A. L., Ueno, M., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2004) · Endocrinology · doi:10.1210/en.2004-0778 · Cited by 46

Metabolic Syndrome and Changes in Body Fat From a Low‐fat Diet and/or Exercise Randomized Controlled Trial

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The metabolic syndrome: a call to action

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Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site

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Association of Variation in the Interleukin-1 Gene Family with Diabetes and Glucose Homeostasis

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Effect of reduced training and training cessation on insulin action and muscle GLUT-4

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Glucose transporter localization in rat skeletal muscle

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Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion

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Tissue-Specific Differences in Activation of Atypical Protein Kinase C and Protein Kinase B in Muscle, Liver, and Adipocytes of Insulin Receptor Substrate-1 Knockout Mice

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Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance

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Dynamin Is Functionally Coupled to Insulin Granule Exocytosis

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The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc

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Entry of Newly Synthesized GLUT4 into the Insulin-responsive Storage Compartment Is Dependent upon Both the Amino Terminus and the Large Cytoplasmic Loop

Khan, A. H., Capilla, E., Hou, J. C., Watson, R. T., Smith, J. R., & Pessin, J. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405694200 · Cited by 39

Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men

Tanner, C. J., Koves, T. R., Cortright, R. L., Pories, W. J., Kim, Y., Kahn, B. B., Dohm, G. L., & Houmard, J. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e147 · Cited by 39

Free fatty acids normalize a rosiglitazone-induced visfatin release

Haider, D. G., Mittermayer, F., Schaller, G., Artwohl, M., Baumgartner-Parzer, S. M., Prager, G., Roden, M., & Wolzt, M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00109.2006 · Cited by 39

Relationship between leisure-time physical activity and metabolic syndrome using varying definitions: 1999-2004 NHANES

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Prostate cancer prevention by nutritional means to alleviate metabolic syndrome

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