The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Open accessAbstract
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2021 The Authors.
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Cites
de Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., Uleryk, E., Budylowski, P., Schünemann, H., Beyene, J., et al. (2015) · BMJ · doi:10.1136/bmj.h3978 · Cited by 1,424 · cited 1×
“These people show an increased mortality compared with non-diabetic populations, for example, a 28% increase in mortality from coronary heart disease (de Souza et al., 2015).”
BackgroundStreptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus
Like, A. A., & Rossini, A. A. (1976) · Science · doi:10.1126/science.180605 · Cited by 979
Diabetogenic action of streptozotocin: relationship of dose to metabolic response
Junod, A., Lambert, A. E., Stauffacher, W., & Renold, A. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106180 · Cited by 930
A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
Reed, M. J., Meszaros, K., Entes, L. J., Claypool, M. D., Pinkett, J. G., Gadbois, T. M., & Reaven, G. M. (2000) · Metabolism · doi:10.1053/meta.2000.17721 · Cited by 848
Studies on the diabetogenic action of streptozotocin
Rakieten, N. (1963) · Medical Entomology and Zoology · Cited by 820
Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., & Ribes, G. (1998) · Diabetes · doi:10.2337/diab.47.2.224 · Cited by 781
Zhang, M., Lv, X.-Y., Li, J., Xu, Z.-G., & Chen, L. (2008) · Journal of Diabetes Research · doi:10.1155/2008/704045 · Cited by 667
Deeds, M. C., Anderson, J. M., Armstrong, A. S., Gastineau, D. A., Hiddinga, H. J., Jahangir, A., Eberhardt, N. L., & Kudva, Y. C. (2011) · Laboratory Animals · doi:10.1258/la.2010.010090 · Cited by 605
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
Skovsø, S. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12235 · Cited by 596
Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes
Wang, B., Chandrasekera, P., & Pippin, J. (2014) · Current Diabetes Reviews · doi:10.2174/1573399810666140508121012 · Cited by 506
Cited by
Grattoni, A., Korbutt, G., Tomei, A. A., García, A. J., Pepper, A. R., Stabler, C., Brehm, M., Papas, K., Citro, A., Shirwan, H., et al. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01029-0 · Cited by 92
Gerace, D., Zhou, Q., Kenty, J. H.-R., Veres, A., Sintov, E., Wang, X., Boulanger, K. R., Li, H., & Melton, D. A. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100879 · Cited by 88
Sun, B. L., Sun, X., Kempf, C. L., Song, J. H., Casanova, N. G., Camp, S. M., Reyes Hernon, V., Fallon, M., Bime, C., Martin, D. R., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202201972rr · Cited by 35
Tang, Q., Tan, Y., Leng, S., Liu, Q., Zhu, L., & Wang, C. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101087 · Cited by 11
Metadata
- Authors
- Furman, B. L.
- Venue
- Current Protocols
- Publisher
- Wiley
- Published
- 2021-04
- Volume
- 1
- Issue
- 4
- Pages
- e78-e78
- ISSN
- 2691-1299 (ISSN-L)
- OpenAlex
- W3159422802
- Cited by
- 874
- References
- 45
- FWCI
- 101.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
