Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

International Diabetes Federation 2017

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Alginate: Properties and biomedical applications

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Generation of Functional Human Pancreatic β Cells In Vitro

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Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

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Efficient differentiation of human embryonic stem cells to definitive endoderm

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p53 mutations in cancer

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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

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Humanized mice in translational biomedical research

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Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

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Streptozotocin‐Induced Diabetic Models in Mice and Rats

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Successful Islet Transplantation

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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

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Humanized Mouse Models of Clinical Disease

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Charting cellular identity during human in vitro β-cell differentiation

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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

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Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

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Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation

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Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

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A prevascularized subcutaneous device-less site for islet and cellular transplantation

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Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

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Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes

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Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

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T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes

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Immune-evasive human islet-like organoids ameliorate diabetes

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Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions

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Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells

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Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

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The pig as a model for immunology research

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Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device

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Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the “Net State of Immunosuppression”

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Perfusion decellularization of whole organs

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Experimental diabetes induced by alloxan and streptozotocin: The current state of the art

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Type 1 Diabetes Mellitus

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Transplantation of human islets without immunosuppression

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Experimental animal models for diabetes and its related complications—a review

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Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells

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Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression

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Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study

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Teratomas from pluripotent stem cells: A clinical hurdle

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Generation of human embryonic stem cell‐derived mesoderm and cardiac cells using size‐specified aggregates in an oxygen‐controlled bioreactor

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Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity

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RIKEN suspends first clinical trial involving induced pluripotent stem cells

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Longitudinal Trends in Glycemic Outcomes and Technology Use for Over 48,000 People with Type 1 Diabetes (2016–2022) from the T1D Exchange Quality Improvement Collaborative

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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes

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Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

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Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada

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Advances in β-cell replacement therapy for the treatment of type 1 diabetes

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Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

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Advanced strategies to thwart foreign body response to implantable devices

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A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.

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Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

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Device design and materials optimization of conformal coating for islets of Langerhans

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Protection of Encapsulated Human Islets Implanted Without Immunosuppression in Patients With Type I or Type II Diabetes and in Nondiabetic Control Subjects

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BCOR Involvement in Cancer

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Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies

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THE PERICYTE OF THE PANCREATIC ISLET REGULATES CAPILLARY DIAMETER AND LOCAL BLOOD FLOW

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Insulin Independence Following Isolated Islet Transplantation and Single Islet Infusions

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Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

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Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques

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Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution

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Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2060: The SEARCH for Diabetes in Youth Study

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International Society for Stem Cell Research

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Oxygen supply to encapsulated therapeutic cells.

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Crossing the bridge: large animal models in translational transplantation research

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Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation

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The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

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Progress in xenotransplantation: overcoming immune barriers

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Hyaluronic acid methacrylate/pancreatic extracellular matrix as a potential 3D printing bioink for constructing islet organoids

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Alginate-microencapsulation of human stem cell–derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

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Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy

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Alginate Encapsulant Incorporating CXCL12 Supports Long-Term Allo- and Xenoislet Transplantation Without Systemic Immune Suppression

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HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes

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Permanent Neonatal Diabetes inINSC94Y Transgenic Pigs

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Generation of pancreatic β cells from CD177+ anterior definitive endoderm

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Engineering the vasculature for islet transplantation

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Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients

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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells

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T cells expressing chimeric antigen receptor promote immune tolerance

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Engineering transferrable microvascular meshes for subcutaneous islet transplantation

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Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice

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Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models.

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Regenerative macrophages enhance stem cell–derived β cell function and engraftment

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Improved Differentiation Towards Insulin Producing Beta-Cells Derived from Healthy Canine Pancreatic Ductal Organoids

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β-Cell Benchmarks: Defining Predictive Outcomes in Islet Transplantation

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Cell therapy for type 1 diabetes: Tracing historical progress and exploring emerging technologies

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Na+/K+-ATPase: a multifunctional target in type 2 diabetes and pancreatic islets

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Generation of fluorescent and bioluminescent induced pluripotent stem cells with their application in tracking organoid development

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Fatty acid-heterocyclic hybrids from green algae as novel therapeutic prospects for diabetes management

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Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy

Greinix, H. T., Matas, A. J., Koh, M., Foeken, L., Worel, N., Vinson, A. J., Ibrahim, H. N., Sawinski, D. L., Seber, A., Valapour, M., et al. (2025) · Clinical Transplantation · doi:10.1111/ctr.70346 · Cited by 1 · see citing works

A stepwise funnel selection approach identifying natural polymer-derived hydrogels for long-term islet delivery, restoring normoglycemia in type-1 diabetes

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Evaluation of a functionalized chitosan and alginate multilayer conformal nanocoating toward improving islet survival in syngeneic mouse islet transplantation

Yitayew, M. Y., Bay, A., Li, L., Piccirillo, C. A., & Tabrizian, M. (2026) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70039 · Cited by 1 · see citing works

Whole-genome CRISPR screening identifies genetic modifiers of stem cell–derived islet transplantation

Maestas, M. M., Bradley, K., Shunkarova, M., Mukherjee, N., Ishahak, M., Lu, J., & Millman, J. R. (2026) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szag012 · Cited by 1 · see citing works

Pancreatic Islet Isolation and Purification from Lewis Rats Using Enzymatic Digestion and Density-Gradient Separation

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Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

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Living Devices for Organ Replacement: The Rise of Bioartificial Organ Engineering

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Wireless electrocatalytic closed-loop system for drug-free management of diabesity

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Pancreatic Ductal Cell Heterogeneity: Insights into the Potential for β-Cell Regeneration in Diabetes

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Generating tolerance through in situ recruitment of regulatory T cells for allogeneic cell transplantation in a bioengineered lymphoid platform

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Causal Associations Between Pre-Pregnancy Diabetes Mellitus and Pre-Eclampsia Risk: Insights from a Mendelian Randomization Study

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In Real Estate as in the Protective Effect of Regulatory T Cells: It Is Location, Location, and Location

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Functionalized cell membrane-coated nanoparticles induce local immune tolerance for durable survival of allogeneic islet grafts

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Mitochondrial homeostasis orchestrates the fate of beta‐cells and the outcomes of islet transplantation

Kuang, B., Zhao, Y., & Gong, N. (2025) · Clinical and Translational Discovery · doi:10.1002/ctd2.70070

Editorial: Linking the endocrine system with immunity

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Hypoxia-associated genes and metabolic abnormalities in peripheral blood mononuclear cells of type 1 diabetes mellitus patients

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Importance of Educational Actions for the Prevention of Complications Arising from Diabetes Mellitus

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Adaptive personalization for wearable non-invasive continuous glucose sensors

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Neue Therapieoptionen bei Diabetes mellitus Typ 1

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Characterization of diffusivity and mechanical properties of polyethylene glycol hydrogel conformal coatings over time for application in beta cell replacement therapy for type 1 diabetes

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Bioengineering of vascular macrodevices for transplantation of insulin-producing cells

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IL-21 mediates crosstalk between T cells and NK cells during the remission of type 1 diabetes

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Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function

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Diabetes Mellitus in the 21st century: Challenges, Breakthroughs, and Unmet Needs

Verma, V., Hussain, I., Shafi, T., Malik, S., Haq, S. I. U., & Ashraf, R. (2026) · Pan-African Journal of Health and Psychological Sciences · doi:10.64261/p91hzy25

Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances

Zhao, M., & Yao, Z. (2026) · Journal of International Medical Research · doi:10.1177/03000605261440833

Adults' Experiences and Perceptions of Electronic Devices for Diabetes Self‐Management: A Qualitative Evidence Synthesis

Porcuna, V. A., Rodríguez-Martín, B., & Avello, D. (2026) · Nursing and Health Sciences · doi:10.1111/nhs.70348

Sustained Approaches to Prevent Recurrence and Support Ongoing Diabetes Health

Ambawatiya, A., Goyal, K., Dahiya, R., Hyderi, Z., Singh, L. K., Srivastava, J., Kumar, N., & Abubakar, M. (2026) · Springer eBooks · doi:10.1007/978-981-95-8946-3_15

Metrnl in diabetes and its complications: divergent evidence and translational prospects

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Optimizing post-transplantation detection of subcutaneously transplanted islets using dithizone staining

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Oral liver-targeted delivery systems for anti-hyperglycemic therapy: From passive to active targeting strategies

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Stem cells-derived islet transplantation toward clinical translation: Divergent strategies and convergent objectives

He, D.-W., Zhang, F., Zhang, H.-X., Xiao, S.-Y., Bi, X.-Y., Wang, Y.-M., Wang, R.-L., Lu, Y.-X., Yin, H., & Li, T. (2026) · World Journal of Diabetes · doi:10.4239/wjd.119760

Nanofibrous Bioabsorbable Functionalized Scaffolds Augment Subcutaneous Islet Engraftment and Function in Mice

Kuppan, P., Castro, C., Paramor, J., Waduthanthri, K. D., Cuesta‐Gomez, N., Bose, A. K., Ma, I., Rosko, M., Pepper, A. R., & Korbutt, G. S. (2026) · Diabetes · doi:10.2337/db26-0149

Inflammatory Preconditioning Reprograms Mesenchymal Stromal Cell-Derived Extracellular Vesicles into Distinct Functional States for Immunomodulation and Wound Healing

Villarreal-Leal, R. A., Velazquez, O. S., Burgelin, B., Pol, R. S. V., Chua, C. Y. X., Conlan, R. S., Finnell, R. H., Grattoni, A., & Corradetti, B. (2026) · Stem Cells and Development · doi:10.1177/15473287261456137

Cell-Based Therapies for Type 1 Diabetes: A Narrative Review of Stem Cell-Derived Islets, Encapsulation Strategies, and Recent Clinical Trials

Guttikonda, S., Machur, J. C., Matha, C. P., Mathew, R. R., & Thotakura, T. (2026) · Cureus · doi:10.7759/cureus.111930

Editorial: Mechanisms of endocrine cell proliferation in the embryonic, neonatal and adult pancreas

Karaköse, E., Spears, E., & Serafimidis, I. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1917333

Allogeneic islet products for type 1 diabetes: Navigating nonclinical and manufacturing regulatory expectations

Press, C., Damour, K., Mamrak, N. E., Pepperl, D., Kutner, R. H., Colleluori, D. M., Graham, M. L., Brehm, M. A., Hussain, N., Latres, E., et al. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102998

IFNα and bleomycin-induced DNA damage activate distinct stress responses in human islets and induced pluripotent stem cell-derived islet cells

Motlagh, R. A., Morelli, N. R., Alcasid, N., & Thompson, P. J. (2026) · Islets · doi:10.1080/19382014.2026.2692859

Integrated transcriptomic and proteomic analysis reveals isolation and culture associated molecular changes in neonatal porcine pancreatic cell clusters

Chen, C.-Y., Chen, C.-L., Kao, C.-W., Cc, C., Hung, W.-W., Chang, C.-W., Juang, J.-H., & Li, W. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12376-8

Biomaterial-Assisted Strategies to Improve Islet Encapsulation and Transplantation for Type 1 Diabetes Therapy

Li, H., Long, P., Qin, W., Chen, X., Liao, C., Shi, H., Liu, Y., & Gao, L. (2026) · ACS Materials Letters · doi:10.1021/acsmaterialslett.6c00481

Ordered compartmentalization in colloidal microspheres: Design strategies and biomedical applications

Cai, Y., Luo, K., Peng, R., Yuan, K., Li, Y., & Huang, C. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.141511

Targeted Regulation of Pancreatic Islet Function by Natural Products Against Type 2 Diabetes Mellitus: Advances and Prospects

Qiao, G., Adejobi, O. I., Li, X., Yang, Y., He, X., Li, L., Zhou, Y., Li, J., Li, H., Zhang, F., et al. (2026) · Biomolecules · doi:10.3390/biom16091338

Engineering Immune‐Protective Stem Cell‐Derived β‐Cell Grafts for Type 1 Diabetes: Encapsulation Technologies and the Emerging Graft Ecosystem

Alanazi, M. A. (2026) · Artificial Organs · doi:10.1111/aor.70245

Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework

Hirani, K., Blaschke, C., Olloqui, C., & Mittal, R. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1915502

Summary Report of the Fifth International Pancreas and Islet Transplant Association Summit on Stem Cell-derived Islets.

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Emerging Therapies in Diabetes: New Drugs and Innovative Remedies

bhavikkimar, P. P., Raval, A. M., Patel, H. B., Patel, K. H., Patel, P., & Prajapati, T. (2026) · Pharmacology and Toxicology Research · doi:10.68163/ptr.2026.61

Once yearly cell-based therapy for sustained and dose-tunable delivery of monoclonal antibodies

Fell, C., Davis, A. E., Pandey, S., Guinn, M. T., Wang, Z., DeBonis, J., Smith, C., Brown, N., Murungi, D., 김연주, et al. (2026) · Science Advances · doi:10.1126/sciadv.aej5440

Human placental decellularized extracellular matrix improves pancreatic progenitor differentiation from human embryonic stem cells compared with defined extracellular matrix protein substrates

Larijani, M. R., Ashtiani, M. K., Tahamtani, Y., Alizadeh, S., Ghezelayagh, Z., Moradmand, A., Aghayan, H. R., & Larijani, B. A. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-02085-1

Greffe d’îlots pancréatiques : une thérapie déjà clinique, un avenir encore à construire

Perrier, Q. (2026) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2026.09.018

Disorders and diseases of the endocrine system

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Recent trends and advances in type 1 diabetes therapeutics: A comprehensive review.

Singh, A., Afshan, N., Singh, A., Singh, S. K., Yadav, S., Kumar, M., Sarma, D., & Verma, V. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151329 · Cited by 30 · see citing works

Cell therapy for type 1 diabetes: Tracing historical progress and exploring emerging technologies

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Islet Cell Replacement and Regeneration for Type 1 Diabetes: Current Developments and Future Prospects

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Challenges in Beta Cell Replacement for Type 1 Diabetes

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Stem cell therapy emerging as the key player in treating type 1 diabetes mellitus

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