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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Lactide Synthesis and Chirality Control for Polylactic acid Production

Open access
Van Wouwe, Pieter, Dusselier, Michiel, Vanleeuw, Evelien, Sels, Bert·2016·ChemSusChem

Abstract

Polylactic acid (PLA) is a very promising biodegradable, renewable, and biocompatible polymer. Aside from its production, its application field is also increasing, with use not only in commodity applications but also as durables and in biomedicine. In the current PLA production scheme, the most expensive part is not the polymerization itself but obtaining the building blocks lactic acid (LA) and lactide, the actual cyclic monomer for polymerization. Although the synthesis of LA and the polymerization have been studied systematically, reports of lactide synthesis are scarce. Most lactide synthesis methods are described in patent literature, and current energy‐intensive, aselective industrial processes are based on archaic scientific literature. This Review, therefore, highlights new methods with a technical comparison and description of the different approaches. Water‐removal methodologies are compared, as this is a crucial factor in PLA production. Apart from the synthesis of lactide, this Review also emphasizes the use of chemically produced racemic lactic acid (esters) as a starting point in the PLA production scheme. Stereochemically tailored PLA can be produced according to such a strategy, giving access to various polymer properties.

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Metadata

Authors
Van Wouwe, P., Dusselier, M., Vanleeuw, E., & Sels, B.
Venue
ChemSusChem
Publisher
Wiley
Published
2016-04-13
Volume
9
Issue
9
Pages
907-921
ISSN
  • 1864-5631 (ISSN-L)
  • 1864-564X
OpenAlex
W2339398593
Cited by
179
References
15
FWCI
5.26
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Lactide Synthesis and Chirality Control for Polylactic acid Production. https://app.cochat.ai/papers/10.1002/cssc.201501695
The paper
Van Wouwe, P., Dusselier, M., Vanleeuw, E., & Sels, B. (2016). Lactide Synthesis and Chirality Control for Polylactic acid Production. ChemSusChem. https://doi.org/10.1002/cssc.201501695

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.