Cited by 78Carbon dioxide utilization in catalysisEnzyme Catalysis and ImmobilizationCO2 Reduction Techniques and Catalysts

Synthetic Enzyme‐Catalyzed CO2 Fixation Reactions

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Aleku, Godwin A., Roberts, George W., Titchiner, Gabriel R., Leys, David·2021·ChemSusChem

Abstract

Abstract In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2‐fixation cascades.

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  • Various useful reduction products such as CO, HCOOH, carboxylic acids, and cyclic carbonates have been successfully obtained through enzymatic and organometallic conversions.

    “Various useful reduction products such as CO, HCOOH, carboxylic acids, and cyclic carbonates have been successfully obtained.330, 331, 332, 333”

    From Technologies and perspectives for achieving carbon neutrality (2021) · cites this paper as [331]

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Authors
Aleku, G. A., Roberts, G. W., Titchiner, G. R., & Leys, D.
Affiliations
  • University of Cambridge (GB)
  • University of Manchester (GB)
Corresponding author
  • Aleku, Godwin A.
  • Leys, David
Venue
ChemSusChem
Publisher
Wiley
Published
2021-03-10
Volume
14
Issue
8
Pages
1781-1804
ISSN
  • 1864-5631 (ISSN-L)
  • 1864-564X
OpenAlex
W3130748263
Cited by
78
References
149
Citations by year
2026: 8 · 2025: 14 · 2024: 23 · 2023: 17 · 2022: 9 · 2021: 7
FWCI
0.84
Type
journal article
Language
en
Open access
Locations
  • ChemSusChem (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion, other-oa)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo
Funders
  • Biotechnology and Biological Sciences Research Council (BB/P000622/1)
  • European Research Council (pre-FAB 695013)
Topics
  • Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › CO2 Reduction Techniques and Catalysts
Keywords
CO2 fixation, decarboxylation, decarboxylase, carboxylase, thermodynamic constraints, enzyme catalysis
MeSH terms
Biotin, Carbon Dioxide, Carboxy-Lyases, Dinitrocresols, Metals, Pyridoxal, Structure-Activity Relationship, Thermodynamics, Thiamine Pyrophosphate, Molecular Structure, Biocatalysis

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