Synthetic Enzyme‐Catalyzed CO2 Fixation Reactions
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Abstract In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2‐fixation cascades.
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Various useful reduction products such as CO, HCOOH, carboxylic acids, and cyclic carbonates have been successfully obtained through enzymatic and organometallic conversions.
“Various useful reduction products such as CO, HCOOH, carboxylic acids, and cyclic carbonates have been successfully obtained.330, 331, 332, 333”
From Technologies and perspectives for achieving carbon neutrality (2021) · cites this paper as [331]
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Cited by
Sorted by citations
Technologies and perspectives for achieving carbon neutrality
Wang, F., Harindintwali, J. D., Yuan, Z., Wang, M., Wang, F., Li, S., Yin, Z., Huang, L., Fu, Y., Li, L., et al. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100180 · Cited by 1,330 · see citing works
- Authors
- Aleku, G. A., Roberts, G. W., Titchiner, G. R., & Leys, D.
- Affiliations
- University of Cambridge (GB)
- University of Manchester (GB)
- Corresponding author
- Aleku, Godwin A.
- Leys, David
- Venue
- ChemSusChem
- Publisher
- Wiley
- Published
- 2021-03-10
- Volume
- 14
- Issue
- 8
- Pages
- 1781-1804
- ISSN
- 1864-5631 (ISSN-L)
- 1864-564X
- PMC
- PMC8252502
- OpenAlex
- W3130748263
- Cited by
- 78
- References
- 149
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 23 · 2023: 17 · 2022: 9 · 2021: 7
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- ChemSusChem (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo
- Funders
- Biotechnology and Biological Sciences Research Council (BB/P000622/1)
- European Research Council (pre-FAB 695013)
- Topics
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › CO2 Reduction Techniques and Catalysts
- Keywords
- CO2 fixation, decarboxylation, decarboxylase, carboxylase, thermodynamic constraints, enzyme catalysis
- MeSH terms
- Biotin, Carbon Dioxide, Carboxy-Lyases, Dinitrocresols, Metals, Pyridoxal, Structure-Activity Relationship, Thermodynamics, Thiamine Pyrophosphate, Molecular Structure, Biocatalysis
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