PTSD SYMPTOMS ACROSS PREGNANCY AND EARLY POSTPARTUM AMONG WOMEN WITH LIFETIME PTSD DIAGNOSIS: Research Article: Peripartum PTSD Trajectories in Women At-Risk
Open accessAbstract
BACKGROUND: Little is known about trajectories of PTSD symptoms across the peripartum period in women with trauma histories, specifically those who met lifetime PTSD diagnoses prior to pregnancy. The present study seeks to identify factors that influence PTSD symptom load across pregnancy and early postpartum, and study its impact on postpartum adaptation. METHOD: The current study is a secondary analysis on pregnant women with a Lifetime PTSD diagnosis (N = 319) derived from a larger community sample who were interviewed twice across pregnancy (28 and 35 weeks) and again at 6 weeks postpartum, assessing socioeconomic risks, mental health, past and ongoing trauma exposure, and adaptation to postpartum. RESULTS: Using trajectory analysis, first we examined the natural course of PTSD symptoms based on patterns across peripartum, and found four distinct trajectory groups. Second, we explored factors (demographic, historical, and gestational) that shape the PTSD symptom trajectories, and examined the impact of trajectory membership on maternal postpartum adaptation. We found that child abuse history, demographic risk, and lifetime PTSD symptom count increased pregnancy-onset PTSD risk, whereas gestational PTSD symptom trajectory was best predicted by interim trauma and labor anxiety. Women with the greatest PTSD symptom rise during pregnancy were most likely to suffer postpartum depression and reported greatest bonding impairment with their infants at 6 weeks postpartum. CONCLUSIONS: Screening for modifiable risks (interpersonal trauma exposure and labor anxiety) and /or PTSD symptom load during pregnancy appears critical to promote maternal wellbeing.
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PTSD during pregnancy is associated with adverse perinatal outcomes, including preterm birth, low infant birthweight, postpartum depression, and impaired maternal-infant bonding.
“PTSD during pregnancy is associated with adverse perinatal outcomes, including preterm birth, low infant birthweight, postpartum depression, and impaired maternal-infant bonding [3–5].”
From Written exposure therapy for treatment of perinatal PTSD among women with comorbid PTSD and SUD: A pilot study examining feasibility, acceptability, and preliminary effectiveness (2023) · cites this paper as [3]
The Introduction links maternal PTSD in pregnancy to low birth weight and preterm labor, but does not specifically say preterm birth. The Results and Discussion associate postpartum depression and mothers’ self-reported bonding impairment with PTSD symptom trajectories—particularly rising symptoms—in women with a lifetime PTSD diagnosis, rather than with PTSD during pregnancy generally. No page numbers are available in our copy. (LLM, conf=0.86)
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- Authors
- Muzik, M., McGinnis, E. W., Bocknek, E., Morelen, D., Rosenblum, K. L., Liberzon, I., Seng, J., & Abelson, J. L.
- Affiliations
- University of Michigan (US)
- Wayne State University (US)
- Corresponding author
- Muzik, Maria
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-01-06
- Volume
- 33
- Issue
- 7
- Pages
- 584-591
- ISSN
- 1091-4269 (ISSN-L)
- PMC
- PMC4930405
- OpenAlex
- W2224336364
- Cited by
- 108
- References
- 65
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 8 · 2022: 15 · 2021: 16 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 4
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000433)
- Michigan Institute for Clinical and Health Research (MH080147, MICHR, UL1TR000433, RR017607, UL1TR000433)
- National Institute of Mental Health (K23MH080147, MH080147-01, MH080147)
- National Institute of Nursing Research (R01NR008767)
- National Center for Research Resources (K12RR017607)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- post-traumatic stress disorder, pregnancy, postpartum period, PTSD symptom trajectories, postpartum depression, maternal-infant bonding, history of child abuse, labor anxiety, maternal mental health
- MeSH terms
- Adaptation, Psychological, Adult, Female, Humans, Pregnancy, Pregnancy Complications, Puerperal Disorders, Socioeconomic Factors, Stress Disorders, Post-Traumatic, Comorbidity
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