Comorbid anxiety in late-life depression: Relationship with remission and suicidal ideation on venlafaxine treatment
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OBJECTIVE: The purpose of this study was to examine the influence of comorbid anxiety symptoms on antidepressant treatment remission in older adults with major depressive disorder (MDD). METHOD: In this multisite clinical trial, 468 older adults aged 60 years or older with MDD received open-label protocolized treatment with venlafaxine extended release (ER) titrated to a maximum of 300 mg daily. At baseline, anxiety was assessed with the Anxiety Sensitivity Index, the Brief Symptom Inventory (BSI) anxiety subscale, and the Penn State Worry Questionnaire. To measure treatment response, depressive symptoms and suicidality were assessed every 1-2 weeks with the Montgomery-Asberg Depression Rating Scale and the 19-item Scale for Suicide Ideation; anxiety was assessed with the BSI. Logistic regression and survival analysis were used to evaluate whether anxiety symptoms predicted depression remission. We also examined the relationships between anxiety scores and suicidality at baseline. RESULTS: Baseline anxiety symptoms did not predict remission or time to remission of depressive symptoms. Depressive, worry, and panic symptoms decreased in parallel in patients with high anxiety. Anxiety symptoms were associated with the severity of depression and with suicidality. CONCLUSION: In older adults with MDD, comorbid anxiety symptoms are associated with symptom severity but do not affect antidepressant remission or time to remission.
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Depression and anxiety often co-occur, with many older adults with depression also experiencing anxiety symptoms.
“In addition, depression and anxiety often co-occur, with studies indicating that many older adults with depression also experience anxiety symptoms (Gao 2023; Saade 2019; Santini 2020).”
From Psychotherapeutic treatments for depression in older adults (2024) · cites this paper as Saade 2019
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- Authors
- Saade, Y. M., Nicol, G., Lenze, E. J., Miller, J. P., Yingling, M., Wetherell, J. L., Reynolds, C. F., & Mulsant, B. H.
- Affiliations
- Washington University in St. Louis (US)
- University of California San Diego (US)
- University of Pittsburgh (US)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Lenze, Eric J.
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2019-11-04
- Volume
- 36
- Issue
- 12
- Pages
- 1125-1134
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- PMC
- PMC6891146
- OpenAlex
- W2989292679
- Cited by
- 47
- References
- 73
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 1 · 2020: 5
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (P30 MH90333, R01 MH083643, R01 MH083648, R01 MH083660, R25‐MH112473)
- Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis
- National Center for Advancing Translational Sciences (UL1TR000448)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- geriatric depression, major depressive disorder, anxiety comorbidity, venlafaxine extended release, antidepressant remission, suicidal ideation, older adults, anxiety sensitivity, worry, panic symptoms, depression severity, time to remission
- MeSH terms
- Venlafaxine Hydrochloride, Aged, Antidepressive Agents, Anxiety, Anxiety Disorders, Depression, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Logistic Models, Survival Analysis, Suicidal Ideation
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