Larger tonic pupil size in young children with autism spectrum disorder
Open accessAbstract
The symptoms of Autism Spectrum Disorder (ASD) have been suggested to manifest from atypical functioning of the autonomic nervous system (ANS), leading to altered arousal and atypical processing of salient stimuli. Coherent with this, persons with ASD show heightened autonomic activity, sleep difficulties, and structural and neurochemical alterations within the ANS. Recently, we observed decreased pupil responses to human faces in children with ASD. In the current study, we found differences in baseline (tonic) pupil size, with the ASD group exhibiting a larger pupil size than age‐matched controls. Pupil responses are sensitive and reliable measures of ANS functioning, thus, this finding highlights the role of the ANS, and may provide clues about underlying neuropathology. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 51: 207–211, 2009
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Children with ASD have larger tonic pupil size.
“More recently, evidence of larger tonic pupil size in children with ASD has also been found (Anderson & Colombo, 2009).”
From Atypical attentional networks and the emergence of autism (2013) · cites this paper as Anderson & Colombo, 2009
Compared with typically developing children, 4-year-old children with ASD have increased tonic pupil size, indicating increased arousal.
“a more recent study by Anderson and Colombo (2009) reported that compared to TD children, 4-year-old children with ASD exhibit increased tonic pupil size, which is indicative of increased arousal.”
From Atypical attentional networks and the emergence of autism (2013) · cites this paper as Anderson and Colombo, 2009
Increased tonic pupil size has been observed in young children with ASD.
“More recently, increased tonic pupil size in young children with ASD has been observed (Anderson & Colombo, 2009).”
From Atypical attentional networks and the emergence of autism (2013) · cites this paper as Anderson & Colombo, 2009
Higher arousal in ASD and related conditions at later stages of development has been reported using a variety of indices, including tonic pupil size, respiratory sinus arrhythmia, baseline heart rate and galvanic skin response.
“Higher arousal in ASD and related conditions at later stages of development has been reported using a variety of indices, including tonic pupil size40, respiratory sinus arrhythmia, baseline heart rate41 and galvanic skin response42 – but has not to our knowledge been researched at the very early stages of development studied here.”
From Shorter spontaneous fixation durations in infants with later emerging autism (2015) · cites this paper as [40]
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A longitudinal study of pupillary light reflex in 6- to 24-month children
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Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders
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The Locus Coeruleus: Where Cognitive and Emotional Processing Meet the Eye
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A Review of Pupillometry for Human-computer Interaction Studies
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Proposed Toxic and Hypoxic Impairment of a Brainstem Locus in Autism
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Gaze Following and Pupil Dilation as Early Diagnostic Markers of Autism in Toddlers
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Pupillary Correlates of Emotion and Cognition: A Computational Model
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Pupillometry in Developmental Psychology
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- Authors
- Anderson, C. J., & Colombo, J.
- Affiliations
- University of Kansas (US)
- Corresponding author
- Anderson, Christa J.
- ORCID
- Colombo, John
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2008-11-05
- Volume
- 51
- Issue
- 2
- Pages
- 207-211
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- PMC
- PMC3744086
- OpenAlex
- W2098768500
- Cited by
- 140
- References
- 36
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 13 · 2013: 13 · 2012: 7
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD002528)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- autism spectrum disorder, pupil response, autonomic nervous system, children, arousal, face processing, pupillometry
- MeSH terms
- Arousal, Autistic Disorder, Humans, Tonic Pupil
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